Navigation Links
New approach for the treatment of malignant brain tumors
Date:10/1/2009

Initial chemotherapy alone after surgery is just as successful as initial radiation therapy for patients from whom a very malignant brain tumor (anaplastic glioma) was removed. With this treatment, the patients survive on average > 30 months without a recurrence. A study conducted by the Neurooncology Working Group of the German Cancer Society led by researchers from Heidelberg and Zrich showed that patients in primary therapy benefit to the same extent from chemotherapy alone as from radiation alone.

In addition, the Working Group headed by Professor Dr. Wolfgang Wick, Medical Director of the Department of Neurooncology at Heidelberg University Hospital and Head of the Neurooncology Unit at the DKFZ, Professor Dr. Michael Weller, Chairman of the Department of Neurology at the University Hospital Zurich, and Prof. Andreas von Deimling, Medical Director of the Department of Neuropathology at Heidelberg University Hospital and Head of the Neuropathology Unit at the DKFZ, identified a new factor that is indicative of a positive prognosis regardless of the form of treatment. The results of the study were published in the Journal of Clinical Oncology.

In Germany, around 4,500 people a year develop a glioma, a malignant brain tumor. Some 5 percent of primary brain tumors are what are known as anaplastic gliomas. They respond to treatment somewhat better than most other malignant brain tumors. The mean survival time in the study was > 80 months. As the tumors can branch out widely into the surrounding tissue, they cannot be completely removed. The subsequent therapy in the form of combined radiochemotherapy (radiation and chemotherapy) is the current standard treatment, but it is associated with a risk of long-term toxicity to healthy brain tissue, causing the patient to lose cognitive abilities.

Primary chemotherapy as an equivalent treatment option

Two studies recently conducted by the European Organization for Research and Treatment of Cancer (EORTC) and the Radiation Therapy Oncology Group (RTOG) have shown that combined radiochemotherapy according to current standard practice does not yield better therapy results than radiotherapy alone. The NOA (Neurooncology Working Group) study has now also proven that chemotherapy alone after surgical removal of the tumor has an equivalent result. "This additional treatment option facilitates the further development of the treatment plan in new combinations with the long-term goal of improving the survival rate," says Professor Wolfgang Wick.

Gene mutation predicts improved outcome

Depending on their tissue composition, anaplastic gliomas are classified in different sub-groups which are assumed to have different prognoses. However, in this study, the previously distinct sub-groups of oligodendroglial tumors had an identical clinical course. With the aid of extensive molecular pathology studies of extirpated tumor tissue, the researchers identified a new prognosis factor called IDH1 mutation (gene mutation of isocitrate dehydrogenase). It is indicative, irrespective of the type of tissue of the anaplastic glioma and irrespective of treatment, of a better prognosis. The researchers proved that the already known prognosis factor "MGMT promoter methylation" is not predictive for chemotherapy, but did have prognostic value for chemotherapy as well as for radiation alone. "The results are relevant not only for clinical routine, but for current study designs of the large study networks EORTC and RTOG as well," explained Professor Wick.


'/>"/>

Contact: Prof. Dr. med. Wolfgang Wick
wolfgang.wick@med.uni-heidelberg.de
062-215-67554
University Hospital Heidelberg
Source:Eurekalert

Related medicine news :

1. Global Regulators to Discuss Benefit-Risk Approaches of Medicinal Products at DIA Workshop
2. Workshop targets control-theoretic approaches for agent-based models
3. Experimental approach may reverse rheumatoid arthritis and osteoporosis
4. Details Emerge About Approach, Results of First US Face Transplant
5. Baucus Approach to Financing Health Care Reform Step in Right Direction
6. Bitemark evidence and analysis should be approached with caution, according to UB study
7. Economic Conditions Signal Long-Term Shift in Rx Benefit Approach
8. WorldatWork Publishes Axiom Consulting Partners' Article on ‘Planning for the New Normal', an Alternative Approach to Compensation Planning
9. A Mediterranean Approach to Flavorful Living
10. Approach Group, Inc. and M. Beacon Enterprises, LLC Announce Strategic Partnership to Provide End-to-End Business Continuity Planning
11. Breakthroughs in Eye Care Products Offer Fresh Approach for Soothing Eyes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... , ... May 05, 2016 , ... Derrin Doty Group ... families of Bremerton, Port Orchard and communities west of Seattle. The insurance provider’s caring ... year local girl who died suddenly due to complications from the flu, that they ...
(Date:5/5/2016)... ... May 05, 2016 , ... A recent survey by the Midwest ... getting employees to understand and use the free preventive care benefits available to them ... business groups of large, self-insured public and private employers, MBGH found that only 10% ...
(Date:5/5/2016)... ... May 05, 2016 , ... Standard ... veterinary professionals across the United States. The whole food nutrient solutions company can ... and giving dog, cat and horse owners’ peace of mind. With the increased ...
(Date:5/5/2016)... ... May 05, 2016 , ... The 2016 Nike Soccer Camp ... along with his university coaching staff. Together they bring their winning Vandals coaching philosophy ... for youth players ages 5-13, and high school players. Session dates are as follows: ...
(Date:5/5/2016)... ... 05, 2016 , ... Chronic stress can have a silent, yet dangerous, impact ... immune system and increase inflammation, both of which raise the risk of heart attack ... disease program at Harvard-affiliated Massachusetts General Hospital. Chronic stress also can lead to other ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 According to ... Growth and Demand Forecast to 2022 - Industry Insights by ... Diagnostic Center and Others)" by P&S Market Research, the global ... in 2015, and it is expected to grow at a ... high slice type segment is expected to witness the faster ...
(Date:5/4/2016)... D.C. , May 4, 2016 ... member companies concluded a series of free workshops ... in global requirements for Good Distribution ... of quality assurance which ensures that products are consistently stored, ... the marketing authorization (MA) or product specification. Only a ...
(Date:5/4/2016)... DUBLIN , May 4, 2016 /PRNewswire/ ... the addition of the  "Global Multiple Myeloma ...  report to their offering.       ... Multiple Myeloma Market and Competitive Landscape Highlights ... pipeline products, Multiple Myeloma epidemiology, Multiple Myeloma ...
Breaking Medicine Technology: