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New approach, old drug show promise against hepatitis C, Stanford research shows
Date:8/31/2008

to its target RNA, but they focused on clemizole because it is already known to be safe in humans. Quake said several of the other compounds were also interesting starting points for developing useful medicines.

Should clemizole prove effective in human trials, Glenn said, it could become an essential component in a new class of multidrug treatments for hepatitis C. Other components could be drugs under development elsewhere that target specific enzymes in the virus. The goal is to improve on the current treatment, a combination of the general antiviral drugs interferon and ribavirin. Those only work about half the time, but have uncomfortable, flulike side effects.

"[Clemizole] does have the potential to be part of a cure, because the idea is not to use it on its own but as a cocktail component," Glenn said.

Similarly it took a cocktail of research expertise to come up with this new assault on the hepatitis C virus, Quake said.

"Neither Jeff's group nor mine could have done this on our own," Quake said. "It was enabled by both of us bringing our pieces to the table: the questions he was asking and the technology we developed."


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Contact: David Orenstein
davidjo@stanford.edu
650-736-2245
Stanford University Medical Center
Source:Eurekalert

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