Navigation Links
New antibiotic drug combo to speed up treatment of tuberculosis
Date:9/18/2007

, ethambutol has been approved to treat TB since 1962.

The three combination drugs, which must be taken several times daily for six to eight months, have all been widely used to treat TB disease for decades: isoniazid (since 1952), rifampin (1968) and pyrazinamide (1954).

It was remarkable to see just how potent moxifloxacin was, says Chaisson. After just two weeks of therapy with moxifloxacin, 21 percent of the sputum samples were negative and cleared of visible disease, while in the ethambutol study group, it was just 3 percent. After four weeks, the gap widened to 51 percent and 29 percent, respectively.

Chaisson says substituting moxifloxacin for one of the key ingredients in DOTS could also make treatment far less costly overall, allowing TB programs to expand their coverage. The medication currently costs $10 per day for short-term use, but the researcher says the drugs manufacturer, Bayer Healthcare AG, has promised to make the drug available at affordable prices in poor countries should it gain approval for use in TB.

Chaisson and his team next plan to investigate a potentially even more potent drug combination that includes traditional DOTS drugs with yet another substitution, rifapentine in place of rifampin. Rifapentine became available in the United States in 1998 and scientists say it is more effective against drug-resistant strains of TB.

Chaisson and colleagues conducted their research with funding from the U.S. Food and Drug Administrations Office of Orphan Product Development. The study was part of a series of studies on moxifloxacin that are being coordinated by the nonprofit Global Alliance for TB Drug Development (GATB) in collaboration with Bayer.

The GATB estimates that 1 billion people worldwide will be infected with tuberculosis by the year 2020, of whom 200 million will fall ill and 35 million will die.

As part of the research program, Bayer donated supplies of moxiflo
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
2. Antibiotics Helps Autism
3. New antibiotic already developing resistance
4. Antibiotics losing their power against acne
5. Antibiotic induces liver damage in children with E.COLI infections.
6. Vaccine Reduces antibiotic-resistant infections in Children
7. Antibiotic from crab blood indentified
8. Gene clue to antibiotics
9. Excessive use of antibiotics for sore throat
10. E. coli strains resistant to a common antibiotic
11. Cost-effective antibiotics for sinusitis treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... To compile the list, the Becker's ... have several awards for clinical and general excellence. The ... out to them in terms of overall excellence, and ... The 50 Great Health Systems to Know 2015 list ... Springs, Fla.) , Advocate Health Care (Downers Grove, Ill.) ...
(Date:5/29/2015)... May 29, 2015 The Healthcare ... graduates of its Advanced Training Program (ATP) in ... fill roles in their health care organization ranging ... and methodology of continuous quality improvement in the ... to Dr. Brent James’ internationally recognized Advanced Training ...
(Date:5/29/2015)... New York (PRWEB) May 29, 2015 ... of patented products, announces that it has signed a ... a technology patent that aims to let people learn ... experts in real time. , "This is an exciting ... Room " said Scott J. Cooper, CEO and Creative ...
(Date:5/29/2015)... Inspire Nexus, a new social network officially launching ... many life coaches have asked, "How do I find ... to become a credentialed Coach?" , Many Life and ... long. Inspire Nexus, a social network for Coaches provides ... have experience coaching a certain number of hours, qualify ...
(Date:5/29/2015)... May 29, 2015 Mediaplanet has joined ... educate readers on the importance of proper sun protection. ... USA Today, with a circulation of approximately 250,000 copies ... component is distributed nationally, through a vast social media ... and partner outlets. To explore the digital version of ...
Breaking Medicine News(10 mins):Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 3Health News:HORNE LLP’s Healthcare Delivery Institute Graduates Class from the Advanced Training Program 2Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 2Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 3Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 4Health News:Licensing Alert! World Patent Marketing's Latest Blockbuster Licensing Deal Gets A New Twist on Technology With The Live Expert Chat Room 5
... of long-term use still outweigh possible benefits , SUNDAY, ... seemed like a wonderful means to help women age ... as their bodies began to produce decreased amounts of ... heart disease, osteoporosis and cancer. , But those beliefs ...
... the annual meeting of the American Sociological Association. Below are ... COUNTRY Gay depictions in the media have "exploded" in ... youth still find it difficult to find people like them on ... to help them come to terms with their sexual identity and ...
... undergoes surgery, follow these helpful tips , SATURDAY, Aug. 8 ... undergoing surgery, it helps if parents and children are well-prepared, ... can be a source of stress for a person of ... whole new layer of sensitivity is added," ASA President Dr. ...
... health-care system perspective, it may be more efficient to use ... have a wild-type KRAS gene, according to a study published ... Cancer Institute . Earlier, patients whose tumors harbored wild-type ... treated with cetuximab in a randomized trial by the National ...
... , , Provides Protection for People with ... WASHINGTON, Aug. 7 The Lupus Foundation of America (LFA) President ... regarding S.1630 "The Affordable Access to Prescription Medications Act of ... (Jay) D. Rockefeller IV (D-WV). , , ...
... , , MORRISTOWN, N.J., ... a leading specialty pharmaceutical company, announced today that one lot of ... is being voluntarily recalled from wholesalers and pharmacies. The recalled ... 2011 and were manufactured by Watson Laboratories, Inc. and distributed by ...
Cached Medicine News:Health News:In U.S., No Comeback Seen for Hormone Therapy 2Health News:In U.S., No Comeback Seen for Hormone Therapy 3Health News:Indiana University research at the American Sociological Association annual meeting 2Health News:Indiana University research at the American Sociological Association annual meeting 3Health News:Indiana University research at the American Sociological Association annual meeting 4Health News:Good Planning Paves Way for Kid's Operation 2Health News:Cost-effectiveness of cetuximab in metastatic colorectal cancer 2Health News:The Lupus Foundation of America Applauds New Legislation that Caps Out-of-Pocket Drug Costs 2Health News:Watson Announces Limited Recall Of Fentanyl Transdermal System 2Health News:Watson Announces Limited Recall Of Fentanyl Transdermal System 3
(Date:5/29/2015)... , May 29, 2015 A six-hour certification program ... being presented at the Cannabis World Congress & Business ... New York, NY .  Taking place on Wednesday, June ... day of education at the leading event on the East ... Led by Clover Leaf University, the first cannabis university ...
(Date:5/29/2015)... , May 29, 2015  Dr. Yair Walzer ... to resolve vaginal health issues often caused by menopause. The ... requires no anesthesia, received FDA clearance in 2014. Dr. Walzer ... to offer the special fractional CO 2 ... breast cancer survivors. In 2010 there were ...
(Date:5/29/2015)... 29, 2015  The annual customer satisfaction survey of ... EMR as #1 across all specialties. Every year, ... conducts a poll of EHR users and publishes an ... Praxis EMR topped 348 other systems, ... based criteria used by Black Book. In addition to ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4The Newest FDA-Cleared Breakthrough In Women's Health Treatments 2Praxis EMR Ranks #1 for Physician Satisfaction in Black Book's 2015 Survey of Solo and Small Practices 2
... Pasteur, the vaccines division of Sanofi (EURONEXT: SAN and ... of a new education campaign designed to help answer ... a reference tool to supplement their discussions about vaccination ... provides consumer-friendly, accurate and science-based information about immunization that ...
... DEERFIELD, Ill., Nov. 17, 2011 Today, Takeda ... (dexlansoprazole) product labeling now includes information from a ... no clinically important effect on exposure to the ... No dose adjustment of clopidogrel is necessary when ...
Cached Medicine Technology:Sanofi Pasteur Launches Nationwide Education Campaign to Help Parents Make Informed Decisions about Immunization 2Sanofi Pasteur Launches Nationwide Education Campaign to Help Parents Make Informed Decisions about Immunization 3Sanofi Pasteur Launches Nationwide Education Campaign to Help Parents Make Informed Decisions about Immunization 4DEXILANT (dexlansoprazole) Product Information Updated Regarding Coadministration with Plavix (clopidogrel bisulfate) 2DEXILANT (dexlansoprazole) Product Information Updated Regarding Coadministration with Plavix (clopidogrel bisulfate) 3DEXILANT (dexlansoprazole) Product Information Updated Regarding Coadministration with Plavix (clopidogrel bisulfate) 4DEXILANT (dexlansoprazole) Product Information Updated Regarding Coadministration with Plavix (clopidogrel bisulfate) 5
... assay is an immunometric ('sandwich') EIA ... in human serum or plasma. LH ... 2 monoclonal anti-LH antibodies directed at ... to magnetic particles and the other ...
... Luteinizing hormone (LH) is a glycoprotein ... the FSH, hCG and TSH, the intact ... alpha- and beta-subunits. These glycoproteins all have ... unique beta-subunit. Both LH and FSH production ...
... StreamLAB combines consolidated ... Systems with pre- and ... an innovative laboratory automation ... needs of today's laboratories, ...
... simplifies and enhances critical care ... features such as its self-contained ... options, the GEM Premier 3000 ... (iQM), an internal, automated program ...
Medicine Products: