Navigation Links
New anti-viral drug shows promise for dramatic improvement in hepatitis C treatment
Date:8/8/2010

apy:

  • To test whether the addition of boceprevir could make it possible to shorten treatment times, some patients were randomly selected to receive the three-drug combination for 28 weeks, some for 48 weeks.
  • Researchers also investigated whether a 4 week lead-in with the standard two-drug combination prior to the addition of boceprevir to the treatment regime could improve sustained virologic response rates. The goal was to see if allowing the interferon and ribavirin to reach steady state levels -- which would activate the immune system and reduce virus levels -- before adding boceprevir would improve the response rates as well as reduce the virus' ability to develop resistance to boceprevir, said Kwo.
  • In another arm of the trial, researchers tested whether a lower dose of ribavirin could reduce the anemia side effects while still treating the virus effectively.

"Both 28- and 48-week boceprevir regimens significantly increased sustained virologic response rates which is the best definition of a cure we have compared to the 48 week control," said Dr. Kwo. "The 48-week treatment arm with 4 weeks of peg interferon lead-in and 44 weeks of peg interferon, ribavirin, and boceprevir led to the largest improvement over the control group ever reported. That's very impressive."

Boceprevir, a product of Merck & Co., is an HCV protease inhibitor a compound designed to block a function key to viral reproduction in the cell. Boceprevir directly targets the hepatitis C virus, Kwo noted, while peginterferon and ribavirin are less specific, acting more generally to stimulate the body's virus-fighting immune system.

The best results were reported for the 103 patients who were treated for four weeks with the standard two drug regiment, followed by 44 weeks of the three-drug regimen including boceprevir: 75 percent of these patients tested negative for evidence of the virus six months after the end of treatment. Results
'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Surgery better than radiation, hormone treatments for some prostate cancer, study shows
2. Women Can Safely Get Pregnant Right After Miscarriage, Study Shows
3. Study shows splitting bowel preparation dosage is most effective cleansing method before colonoscopy
4. Epilepsy Drugs Dont Raise Suicide Risk, Study Shows
5. Iron-regulating protein is strong predictor of breast cancer prognosis, study shows
6. Brain study shows that thinking about God reduces distress -- but only for believers
7. Survey of coastal residents shows Gulf oil spill has significant impact on families
8. Vaccine Shows Some Promise Against Advanced Cancers
9. Women attracted to men in red, research shows
10. Most youth hockey injuries caused by accidents, not checking, UB study shows
11. Most Men With Low-Risk Prostate Cancer Treated Aggressively, Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New anti-viral drug shows promise for dramatic improvement in hepatitis C treatment
(Date:9/1/2015)... , ... September 01, 2015 , ... Dr. Trace Curry ... JourneyLite of Cincinnati. In the last month the FDA has approved two intra-gastric ... ™. These procedures represent the first incisionless, reversible, weight loss procedures available to ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... men and pick-up artists about their experiences of female beauty, women’s emotions, fertility, ... including penis issues, as well as their relationships with other men, documenting how ...
(Date:9/1/2015)... ... September 01, 2015 , ... A new episode of ... will take a look at the topic of arthritis. There are over 100 different ... explore interesting arthritis types and statistics in an effort to shed light on this ...
(Date:9/1/2015)... ... 01, 2015 , ... The premier online medical education company ... leader in podiatric, surgical and wound care conferences . The Residency Education ... speakers at the podium and across the table during hands-on surgical and advanced ...
(Date:8/31/2015)... , ... September 01, 2015 , ... ... eliminate chronic back pain – once required a long, arduous recovery. However, today’s ... stay, less pain, less blood loss and minimal muscle damage. These advantages of ...
Breaking Medicine News(10 mins):Health News:Dr. Trace Curry Performs First ORBERA™ Intra-gastric Balloon in Ohio at JourneyLite, a New Incisionless Option For The Treatment of Obesity 2Health News:Female Porn Director Explains Male Insecurities about Women in a New Book 2Health News:PRESENT e-Learning Systems Announces their 2016 Podiatry and Wound Care Medical Education Conference Schedule 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 3Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 4
... , TONBRIDGE, England, Aug. 21 Medicine ... deteriorate and even being admitted to hospital, a Chemist+Druggist (C+D) survey ... community pharmacies that responded, almost a third said patients had already ... , , Pharmacists have reported growing difficulty getting ...
... , TUCSON, Ariz., Aug. 21 Natural Health ... called NaturalPedia.com. , , NaturalPedia.com combines the wisdom of ... displaying collections of knowledge on specific topics such as " chl ... D ". , , NaturalPedia also pairs two-term concepts ...
... way the brain responds to music , FRIDAY, Aug. ... enjoyable activities is a common sign of depression -- ... see in the brain. , When listening to ... regions of the brain that are involved with experiencing ...
... , Global health organization PSI helps contestants ... NASSAU, Bahamas, Aug. 21 The Miss Universe contestants ... Condom Olympics - tossing water-filled condoms to test their strength and ... HIV infection. The games are part of an HIV peer ...
... ... ... 2009 -- MesoRC.com, an online community and resource center developed to assist those affected ... of valuable information with the introduction of Twitter. The goal is to provide an ...
... , LOS ANGELES, Aug. 20 Burner ... Energy-X, a new lip balm that delivers an effective and healthier alternative ... calories, Energy-X provides the energy boost consumers want without the added calories ... is applied directly on the lips and is therefore absorbed faster into ...
Cached Medicine News:Health News:Distressed Patients Suffer Panic Attacks as UK Medicine Stocks Hit by Shortages, Chemist+Druggist Reveals 2Health News:New Online Health Encyclopedia NaturalPedia.com Distills Knowledge From Industry's Top Authors 2Health News:Depression's Effect on Pleasure Is Real 2Health News:Miss Universe Contestants Enter Condom Olympics to Tackle HIV 2Health News:Miss Universe Contestants Enter Condom Olympics to Tackle HIV 3Health News:Mesothelioma Resource Center Enters Twitter World 2Health News:Energy-X Lip Balm Delivers Wake-Up Call to Consumers 2
(Date:8/31/2015)... , Aug. 31, 2015  AMRI (NASDAQ: ... announced a strategic collaboration focused on the development, ... active pharmaceutical ingredients, ("APIs"). The collaboration combines Saneca,s ... their expertise in developing and manufacturing controlled substance ... to tech transfer processes into these facilities. The ...
(Date:8/31/2015)... August 31, 2015 Premune ... into an exclusive licensing agreement for Redonyl ® ... $300 million USD veterinary dermatology market, is a nutritional ... support healthy skin in dogs and cats. Redonyl ® ... , and has been received positively in the ...
(Date:8/31/2015)... Aug. 31, 2015  QT Vascular Ltd., together with its ... with its subsidiaries, the "Group"), a global company ... advanced therapeutic solutions for the minimally invasive treatment ... of the below-the-knee ("BTK") cohort of patients in ... presented on August 15, 2015 at the 5th ...
Breaking Medicine Technology:AMRI Announces Agreement with Saneca Pharmaceuticals, a.s. for Portfolio of Opium-Derived Active Pharmaceutical Ingredients 2AMRI Announces Agreement with Saneca Pharmaceuticals, a.s. for Portfolio of Opium-Derived Active Pharmaceutical Ingredients 3AMRI Announces Agreement with Saneca Pharmaceuticals, a.s. for Portfolio of Opium-Derived Active Pharmaceutical Ingredients 4Premune Broadens Portfolio With Novel Innovet Skin Health Product 2Premune Broadens Portfolio With Novel Innovet Skin Health Product 3Premune Broadens Portfolio With Novel Innovet Skin Health Product 4Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4
... , April 29, 2010 Albireo today,announced ... recent study,assessing the safety, tolerability and efficacy of A3309 ... compound for,the treatment of irritable bowel syndrome with constipation ... during the 2010,Digestive Disease Week (DDW) annual meeting being ...
... SALT LAKE CITY , April 28 Sonic Innovations, ... Administration (VA), is conducting ongoing training events for government clinicians.  The company ... in San Diego, California and April 25 through ... for May 3 through 5 in Salt Lake City, ...
Cached Medicine Technology:Albireo Announces Positive Results From a Study With A3309 in Patients With Chronic Constipation 2Albireo Announces Positive Results From a Study With A3309 in Patients With Chronic Constipation 3Albireo Announces Positive Results From a Study With A3309 in Patients With Chronic Constipation 4Albireo Announces Positive Results From a Study With A3309 in Patients With Chronic Constipation 5Sonic Innovations Conducts National Training Events for Government Clinicians 2Sonic Innovations Conducts National Training Events for Government Clinicians 3
Hemagglutination slide test for the qualitative and quantitative detection of Rheumatoid Factor in serum or synovial fluid....
Hemagglutination slide test for the differential qualitative detection and quantitative determination of infectious mononucleosis and other heterophile antibodies in serum or plasma....
Color-enhanced hemagglutination slide test for the rapid qualitative and semi-quantitative detection of infectious mononucleosis heterophile antibodies in serum or plasma....
... Inverness Medical Professional Diagnostics is a leading ... IFA and DFA test menu that includes ... STDs as well as miscellaneous conjugates and ... you a wide assortment of substrates and ...
Medicine Products: