Navigation Links
New anti-inflammatory drugs might help avoid side effects of steroids
Date:10/25/2011

off the invading microbes. In the case of autoimmune diseases and cancer tumors, the cytokines are released inappropriately, causing inflammation that serves no immune function. Steroids help counter this inflammation.

However, Evans, a Howard Hughes Medical Institute Investigator, points out that steroids can produce serious side effects, including immune system suppression, high blood sugar, muscle weakness and glaucoma that limit their use.

"To reduce these complications we wanted to know whether there are missing links in the steroid chain of suppression that can help us reduce some of the side effects," Evans says. "To figure out the chain of events, at the molecular level, we teamed with Verma and together uncovered the hidden link that may lead to new drugs targets."

The scientists found a potential new target by genetically modifying a strain of mice to silence the gene that produces the p53 tumor suppressor protein. As a result, glucocorticoids were ineffective at countering the inflammation response in the mice, meaning that p53 is key gear in the cellular mechanism that allows the steroids to suppress inflammation.

Due to p53's role in suppressing cancer, scientists have already identified a number of other proteins capable of altering its activity. Based on their findings, the researchers think these proteins also might be effective as anti-inflammatory drugs that operate by stimulating p53 activity. This could offer the possibility of powerful anti-inflammatories without the nasty side effects of steroids.

Their results also suggest that some cancer patients, who have a genetic mutation in their tumors that results in abnormal p53 activity, might be suffer through the side effects of steroids for no reason.

"If p53 is required for glucocorticoids to work, yet their tumor cells aren't producing p53 normally, they may be receiving steroid treatment and dealing with the ramifications with no thera
'/>"/>

Contact: Andy Hoang
Ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Common anti-inflammatory coaxes liver cancer cells to commit suicide
2. Anti-inflammatory drug may fight breast cancer
3. Non-steroidal anti-inflammatory drugs linked to increased risk of erectile dysfunction
4. Anti-Inflammatory Helps Treat Bacterial Meningitis: Study
5. Grant for rotten eggs anti-inflammatory research
6. New research reinforces anti-inflammatory properties of tart cherries
7. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
8. Physician's Pain Relief Cream Includes Patented Anti-inflammatory in New Formula
9. Prozac and Celexa exhibit anti-inflammatory effects
10. Double duty for blood pressure drugs: how they could revolutionize how we treat valve disease
11. Are acid-suppressing drugs prescribed too often in infants?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New anti-inflammatory drugs might help avoid side effects of steroids
(Date:8/28/2014)... 29, 2014 Recently, iFitDress.com, the distinguished ... selection of chic bridesmaid dresses . Included in ... In addition, all of them are provided at deeply ... iFitDress.com insists on offering fast and reliable delivery service. ... they order in a short time. As is commonly ...
(Date:8/28/2014)... 28, 2014 Millennium Treatment Group ... September. This month will be a celebration of ... health services. Along with other treatment facilities and ... to spread the word about this national observance. ... the work of treatment and recovery professionals, and ...
(Date:8/28/2014)... Aug. 28, 2014 (HealthDay News) -- Arguments between parents ... study indicates. Parents in more than 200 families ... days. At the end of each day, mothers and ... relationship with their children. On days when parents ... with their children were also strained, according to the ...
(Date:8/28/2014)... and Ann Arbor, MI (PRWEB) August 28, 2014 ... company and the nation’s leading intraoperative neurophysiology monitoring ("IONM") ... and CFO, to the position of Chief Executive Officer ... CFO, was promoted to President and CFO in 2013 ... growth and success. , “Bill’s efforts and achievements ...
(Date:8/28/2014)... Bank lending to the private sector in the ... in real terms, and continuing to fall behind the rest ... the international accountancy network. , UHY warns that the figures ... credit crunch lingers on. , UHY says in the US, ... been wiped out by inflation. Over the four years since ...
Breaking Medicine News(10 mins):Health News:New Selection of Chic Bridesmaid Dresses Available at iFitDress.com 2Health News:Millennium Treatment Group Celebrates National Recovery Month 2Health News:Parents' Fights May Strain Bonds With Their Kids 2Health News:Biotronic NeuroNetwork Announces the Promotion of Bill Gecsey to CEO 2Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 2Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 3Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 4Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 5Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 6Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 7
... days, experts say, , , THURSDAY, Jan. 3 (HealthDay News) -- ... be passed from one person to another through contact with ... U.S. health officials report. , The virus, which is common ... of vomiting and diarrhea in the United States, is often ...
... Examined, ARLINGTON HEIGHTS, Ill., Jan. 3 ... new,knowledge about the effects of silicone breast implants. ... the official,medical journal of the American Society of ... impact and health concerns of silicone,breast implants., ...
... Abbott (NYSE: ABT ),will announce its financial ... 2007, on Wednesday, Jan. 23, 2008, before the market ... live webcast of the earnings,conference call at 8 a.m. ... Abbott,s Investor Relations Web site at, http://www.abbottinvestor.com . An ...
... who,purchased or were given "home-canned" soup or other ... County, should not open the jars due,to the ... B.,Johnson said today., Consumers who obtained canned ... Department of Health, toll-free, at,877-PA-HEALTH., The state ...
... Idaho, Jan. 3 RxElite, Inc. (OTC,Bulletin Board: ... prescription drug products, announced today that a registration,statement ... stockholders,was declared effective by the Securities and Exchange ... provided for informational purposes only, and does not,represent ...
... body,s health, researchers say , , THURSDAY, Jan. 3 (HealthDay News) ... a placebo to a patient during their years of practice, ... in the study also said they believed in the power ... that can affect health, the researchers said. , A ...
Cached Medicine News:Health News:Stomach Flu Spread By Contaminated Computer Keyboards 2Health News:Stomach Flu Spread By Contaminated Computer Keyboards 3Health News:ASPS Studies Re-Evaluate Psychological Benefits and Health Concerns of Silicone Breast Implants 2Health News:Health Department Warns Consumers of Home-Canned Soup Linked to Potter County Restaurant 2Health News:RxElite Registration Statement Declared Effective by Securities and Exchange Commission 2Health News:Almost Half of Doctors Have Prescribed Placebos 2
(Date:8/28/2014)... , Aug. 28, 2014  Rigrodsky & Long, P.A.: ... Lannett Company, Inc. (NYSE: LCI )? , Did ... 10, 2013 and July 16, 2014, inclusive? , Did ... , Do you want to discuss your rights? ... Assistant United States Attorney, Timothy J. MacFall , announces that ...
(Date:8/28/2014)... 28, 2014 Reportlinker.com announces that ... in its catalogue: Needle-Free Delivery: ... http://www.reportlinker.com/p02332847/Needle-Free-Delivery-Technology-and-Market-Forecast-2014-2024.html Report ... and commercial prospects What does the future ... brand new report shows you the potential ...
(Date:8/28/2014)... NEW YORK , Aug. 28, 2014 /PRNewswire/ ... report is available in its catalogue: ... http://www.reportlinker.com/p02343464/North-America-Laparoscopes-Market-Outlook-to-2020.html North ... GlobalData,s new report, "North America Laparoscopes Market ... the North America Laparoscopes market. The report provides ...
Breaking Medicine Technology:Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 2Needle-Free Delivery: Technology and Market Forecast 2014-2024 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 4Needle-Free Delivery: Technology and Market Forecast 2014-2024 5Needle-Free Delivery: Technology and Market Forecast 2014-2024 6Needle-Free Delivery: Technology and Market Forecast 2014-2024 7Needle-Free Delivery: Technology and Market Forecast 2014-2024 8Needle-Free Delivery: Technology and Market Forecast 2014-2024 9Needle-Free Delivery: Technology and Market Forecast 2014-2024 10Needle-Free Delivery: Technology and Market Forecast 2014-2024 11Needle-Free Delivery: Technology and Market Forecast 2014-2024 12Needle-Free Delivery: Technology and Market Forecast 2014-2024 13Needle-Free Delivery: Technology and Market Forecast 2014-2024 14Needle-Free Delivery: Technology and Market Forecast 2014-2024 15Needle-Free Delivery: Technology and Market Forecast 2014-2024 16Needle-Free Delivery: Technology and Market Forecast 2014-2024 17Needle-Free Delivery: Technology and Market Forecast 2014-2024 18North America Laparoscopes Market Outlook to 2020 2North America Laparoscopes Market Outlook to 2020 3North America Laparoscopes Market Outlook to 2020 4North America Laparoscopes Market Outlook to 2020 5North America Laparoscopes Market Outlook to 2020 6North America Laparoscopes Market Outlook to 2020 7North America Laparoscopes Market Outlook to 2020 8North America Laparoscopes Market Outlook to 2020 9North America Laparoscopes Market Outlook to 2020 10North America Laparoscopes Market Outlook to 2020 11
... N.Y., Sept. 9 Misonix, Inc. (Nasdaq: ... the art, ultrasonic medical device technology, which worldwide ... into a new, three year, exclusive distribution agreement ... will sell and distribute the SonaStar® Ultrasonic Surgical ...
... video detailing has made a strong comeback after ... and healthcare market research company Manhattan Research,s ... detailing has more than doubled in the past two years, ... self-report that their prescribing behavior is influenced by these programs, ...
Cached Medicine Technology:Misonix Announces New Distribution Agreement For Spain 2Misonix Announces New Distribution Agreement For Spain 3New Study: Physician Adoption of Live Video Detailing Has Doubled Since 2008, But Will Likely Plateau Until 2012 as Pharma Optimizes Targeting 2New Study: Physician Adoption of Live Video Detailing Has Doubled Since 2008, But Will Likely Plateau Until 2012 as Pharma Optimizes Targeting 3
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
... Laparoscopic Instruments incorporate a layered design unique ... and monitored to prevent stray electrosurgical burns ... by insulation failure or capacitive coupling; a ... built into all AEM Instruments provides a ...
... Laparoscopic Instruments incorporate a layered design unique ... and monitored to prevent stray electrosurgical burns ... by insulation failure or capacitive coupling; a ... built into all AEM Instruments provides a ...
... Wolf offers protection in ... shielding values with lightweight ... optical quality. Lenses provide ... and are anti-reflection coated ...
Medicine Products: