Navigation Links
New animal model may lead to treatments for common liver disease
Date:7/3/2012

Scientists at Texas Biomed have developed the laboratory opossum as a new animal model to study the most common liver disease in the nation afflicting up to 15 million Americans and for which there is no cure.

The condition, nonalcoholic steatohepatitis (NASH), resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. The major feature of NASH is accumulation of fat in the liver, along with inflammation and functional damage. Most people with NASH feel well and are not aware that they have a liver problem. Nevertheless, NASH can progress to cirrhosis, in which the liver is permanently damaged and no longer able to work properly. NASH-related cirrhosis is the fourth most common indication for liver transplantation in the U.S.

NASH affects 2 to 5 percent of Americans roughly six million to 15 million people. An additional 15 to 30 percent of Americans have excess fat in their livers, but no inflammation or liver damage, a condition called "fatty liver" or the non-progressive form of nonalcoholic fatty liver disease (NAFLD).

The study, published in the July issue of the American Journal of Physiology-Gastrointestinal and Liver Physiology, was supported by the National Institutes of Health and the Robert J. Kleberg, Jr., and Helen C. Kleberg Foundation.

"This is the type of model in which to develop mechanism-based therapies," writes Geoffrey C Farrell, M.D., of the Australian National University Medical School in Canberra, in a journal editorial.

Both NASH and NAFLD are becoming more common, possibly because of the greater number of Americans with obesity and its important health complications, type 2 diabetes, high blood cholesterol levels, high blood pressure and other risk factors for heart attack and stroke. In the past 10 years, the prevalence of obesity has doubled in adults and tripled in children. It was previously reported by other scientists that the prevalence of NAFLD and NASH in a cohort of
'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Potential treatment target identified in an animal model of pancreatic cancer
2. New technique could reduce number of animals needed to test chemical safety
3. Chicago Dog Bite Injury Lawyers Advise Dog Owners To Get Control of Their Animals, Or Be Prepared To Pay Up
4. Woodbridge Animal Hospital Unleashes New Pet Care Website
5. Recruiting for Good Launches Pet Philanthropy Program to Collaboratively Fundraise for Kitt Crusaders an Animal Rescue Organization
6. Raucous Music May Tap Into Your Inner Animal
7. Animals More Interesting to Kids Than Toys, Study Shows
8. FDA Seeks to Limit Antibiotics in Animal Feed
9. Researchers develop a new cell and animal model of inflammatory breast cancer
10. DeNova Homes at Southgate, Announces Single Story Model Opening
11. Human model of Huntingtons disease created from skins stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Dr. Trace Curry successfully ... of Cincinnati. In the last month the FDA has approved two intra-gastric balloons, ... These procedures represent the first incisionless, reversible, weight loss procedures available to Americans. ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... for Alfresco, a next-generation customer communications archiving solution integrated with Alfresco‘s enterprise ... from Crawford and helps organizations save millions of dollars in printing costs ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... and pick-up artists about their experiences of female beauty, women’s emotions, fertility, female ... penis issues, as well as their relationships with other men, documenting how the ...
(Date:9/1/2015)... York (PRWEB) , ... September 01, 2015 , ... Anthony ... of the Super Lawyers 2015 for his third consecutive year in a row. ... and accomplishments of helping people. , Born in Niagara Falls, New York, Tantillo is ...
(Date:9/1/2015)... ... September 01, 2015 , ... A new episode of ... will take a look at the topic of arthritis. There are over 100 different ... explore interesting arthritis types and statistics in an effort to shed light on this ...
Breaking Medicine News(10 mins):Health News:Dr. Trace Curry Performs First ORBERA™ Intra-gastric Balloon in Ohio at JourneyLite, a New Incisionless Option For The Treatment of Obesity 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 3Health News:Female Porn Director Explains Male Insecurities about Women in a New Book 2
... The Center for Aging Services Technologies (CAST) today ... in Aging Services Report" that lays out the categories ... meet the needs of aging consumers and highlights what ... This version, which can be found online at ...
... reconsider or defer purchases of imaging IT systems, ... According to Millennium Research Group,s (MRG,s) ... report, the budgetary constraints facing many health ... picture archiving and communication systems (PACS), radiology information ...
... as President and Chief Executive Officer , ... (OTC Bulletin Board: PSTX) today announced that David Bruce ... Executive Officer and will also join its Board of ... will remain involved with the company as a consultant.David ...
... weight loss surgery, the number of physicians performing these procedures has ... board-certified surgeon who is a member of the American Society of ... , ... (Vocus) January 8, 2009 -- Due to the ...
... to cellphones, especially after 9 p.m., can increase the likelihood of ... as well as those from other electrical appliances and high voltage ... the cerebrospinal fluid (CSF) and simultaneously suppress the synthesis of the ... ...
... care costs could have the unintended consequence of reducing ... two Beth Israel Deaconess Medical Center physicians suggest in ... , Citing studies in behavioral economics and psychology, Pamela ... that assigning a monetary value to every aspect of ...
Cached Medicine News:Health News:Interactive Report Maps Landscape of Technology for the Aging 2Health News:Budgetary Constraints on Health Care Facilities to Affect PACS, RIS, and CVIS Markets 2Health News:Patient Safety Technologies Announces Expansion of Senior Management Team 2Health News:Choosing a Highly-Trained Bariatric Surgeon Crucial as Surgical Weight Loss Procedures Rise and Less-Qualified Doctors Flood the Market 2Health News:Choosing a Highly-Trained Bariatric Surgeon Crucial as Surgical Weight Loss Procedures Rise and Less-Qualified Doctors Flood the Market 3Health News:Welsh Laboratory Discovers Natural Antidote for Sleep Disturbance Caused by Cell Phones; Don't Disturb Me! Asphalia for Natural Sleep 2Health News:Welsh Laboratory Discovers Natural Antidote for Sleep Disturbance Caused by Cell Phones; Don't Disturb Me! Asphalia for Natural Sleep 3Health News:Cost containment focus could have consequences for health care delivery 2
(Date:8/31/2015)... SAN FRANCISCO , Aug. 31, 2015  On ... District of Oregon denied motions ... Inc. (NASDAQ: GALE ) and certain of its ... had facilitated a "pump and dump" scheme to artificially ... trading period while the stock price was inflated, sold ...
(Date:8/31/2015)... 31, 2015  Regulatory affairs professionals work at ... are often strict and legislation is ever-changing. The ... for professionals who have a deep understanding of ... product lifecycle and demonstrate its use across various ... California, Irvine Extension , in partnership with the ...
(Date:8/31/2015)... Aug. 31, 2015 Regen BioPharma, Inc. (OTCBB: ... a novel means of delivering its patented (US ... liver tumors utilizing a clinically approved formulation as ... hurdles with gene silencing therapeutics in which the ... the whole body.  By utilizing a local delivery ...
Breaking Medicine Technology:Galena Biopharma, Inc. Stock Alert: Schubert Firm Investigates Potential Breaches of Fiduciary Duty 2UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 2UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 3Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3
... Ore.--(BUSINESS WIRE)--Jul 10, 2007 - AVI BioPharma, Inc.,(Nasdaq:AVII) ... target patient enrollment and released six-month,follow-up data from ... trial, currently being held in Germany, was designed ... Resten-MP(TM), when,used in conjunction with the placement of ...
... Fail to Demonstrate Meaningful Placebo Adjusted Weight,Loss; ... July 09, 2007 /PRNewswire-FirstCall/ -- Manhattan,Pharmaceuticals, Inc. ... 2a clinical trials of oral Oleoyl-estrone (OE). ... one,in common obesity and the other in ...
Cached Medicine Technology:AVI BioPharma Partner Cook Medical Announces Completion of Patient,Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of,Cardiovascular Disease 2Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for,Oral Oleoyl-estrone 2Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for,Oral Oleoyl-estrone 3Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for,Oral Oleoyl-estrone 4
Open blade design with aspiration capabilities for removing fluids from the operative site. 19 gauge wire....
Designed to provide open approaches of the keratome to the cornea for either the left or right eye. Lightweight wire design adds to the comfort of the instrument when in place....
Solid 14 mm free-swinging blades, suture posts, and stabilizing disk. Dull finish....
Designed for use with foster enucleation snare (E3670). Package of 12 stainless steel wires. Overall length 5.3 inches....
Medicine Products: