Navigation Links
New anemia measure predicts risk of death in dialysis patients
Date:11/13/2007

Washington, DC (Tuesday, November 13, 2007) A new indicator of variations in hemoglobin level over time is a strong predictor of the risk of death among patients receiving dialysis for end-stage renal disease (ESRD), reports a study in the December Journal of the American Society of Nephrology.

"Hemoglobin variabilitya measure of the stability of levels of hemoglobin among chronic hemodialysis patientsprovides a novel way of thinking about and understanding the relationship between anemia and outcomes in ESRD," comments Dr. Harold I. Feldman of University of Pennsylvania School of Medicine, Philadelphia, one of the study authors.

The researchers used data on nearly 35,000 dialysis patients to analyze the effects of hemoglobin variability on the risk of death. They focused on a newly developed metric, termed Hb-Var, that measures variability in hemoglobin levels independent of their absolute values and trends over time.

Hemoglobin is the oxygen-carrying compound in the blood. Anemia, or low hemoglobin levels, is one of the most frequent complications of kidney failure and a common cause of death in dialysis patients. Treatment including erythropoietin and intravenous iron has been a major advance in the management of kidney failure-related anemia, yet low blood counts and variation in hemoglobin levels continue to be a problem for many dialysis patients.

The new study found that high Hb-Var scoresindicating greater hemoglobin variabilitypredicted a higher risk of death in dialysis patients. For each 1 g/dL (gram per deciliter) increase in Hb-Var, the risk of death increased by 33 percent, after adjustment for other factors.

The relationship between Hb-Var and mortality remained significant even after adjustment for absolute hemoglobin levels and trends in hemoglobin levels over time. Higher Hb-Var scores predicted an increased risk of death in nearly all subgroups of dialysis patients. "As postulated, higher levels of hemoglobin variability were associated with higher rates of death," says Dr. Feldman.

In healthy people, hemoglobin levels typically remain within a narrow range, ensuring consistent delivery of oxygen to organs and tissues. In dialysis patients, repeated drops in hemoglobin levelsand thus in the ability to deliver adequate levels of oxygenmay result in injury to organs. The heart muscle (myocardium) and autonomic nervous system may be especially vulnerable, which may help to explain the increased rates of cardiovascular disease and death in ESRD patients.

The new study identifies Hb-Var as a potentially valuable measure of the effects of low hemoglobin in ESRD, and lends new insights into how anemia affects outcomes in dialysis patients. Dr. Feldman concludes, "These findings may ultimately lead to health care practice changes regarding the management of anemiafor example, the type, dose, and timing of treatment with erythropoietin and ironthat might improve outcomes among hemodialysis patients."


'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
2. Controversial Anemia Drug Doesnt Cut Need for Transfusions
3. Cancer Doctors Across America Stunned at Governments Ruling Restricting Anemia Management Protocols for Cancer Patients, Call Ruling Interference in Practice of Medicine
4. Simpler Anemia Treatment May Help Kidney Patients
5. FDA Issues New Warnings for Anemia Drugs
6. Use of certain lipid measures not more effective in predicting coronary heart disease
7. Wild American Shrimp Board Agrees To Implement New Self-Funding Measures
8. Valley Health System Caregivers, Members of SEIU UHW, to Announce Endorsement of Measure G
9. People overestimate their self-reported sleep times compared to measures by a sleep test
10. Brain measurements could lead to better devices to move injured or artificial limbs
11. PA Health Department Suggests Measures to Reduce the Spread of MRSA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... The National Campaign ... for the Access to Contraception for Women Servicemembers and Dependents Act of 2017. ... (D-CA), will help to ensure that all members of the Armed Forces receive ...
(Date:4/28/2017)... ... , ... It's not always common knowledge whether or not a certain sickness ... to whether or not they are contagious, and most people don't know the answer ... took a look into the matter. , They discovered that the main reason ...
(Date:4/28/2017)... UT (PRWEB) , ... April 28, 2017 , ... Beginning ... some of their formulas. This begins with the popular ClearLungs Extra Strength formula. To ... be changing the formula in the following ways:, , Removal ...
(Date:4/28/2017)... ... April 28, 2017 , ... Getting enough sleep affects much more than energy – it ... 19 hours without sleep can compromise motor reaction time, which can increase the risk of ... is sharing the following tips from the NSF to help you sleep better and feel ...
(Date:4/28/2017)... ... April 28, 2017 , ... Date aired: April ... “Computers are everywhere and they’re here to stay,” said Sharon Kleyne on her ... Your Health on Voice America sponsored by Nature’s Tears® EyeMist®. So she was ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017  IRIDEX Corporation (Nasdaq: ... results for the first quarter 2017 after the close ... management team will host a corresponding conference call beginning ... Investors interested in listening to the conference call ... callers or (703) 326-3030 for international callers, using conference ...
(Date:4/19/2017)... 2017 The Global Effective Microorganisms (EM) ... report has covered and analysed the potential of Global Effective ... size, shares and growth factors. The report identifies and analyses ... in the global market. ... Browse 152 Tables and Figures, 6 Major Company Profiles, spread ...
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
Breaking Medicine Technology: