Navigation Links
New analysis shows liver cancer incidence has tripled since 1970s, but survival rates improving

Study Summary

A new study examining data on incidence trends, mortality rates and survival rates from the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) cancer registries indicates that the incidence of liver cancer in the United States tripled between 1975 and 2005.

Researchers also found for the first time that one- through five-year survival rates improved significantly for patients diagnosed with liver cancer between 1992 and 2005, in part because more patients were diagnosed at earlier stages, when treatment is more effective. Earlier diagnosis may be due to increasing awareness and screening to detect localized disease in patients at risk for liver cancer.

"Although the study could not determine why liver incidence rates are increasing, these trends may be partially attributable to an increase in chronic hepatitis C, which together with hepatitis B is a major risk factor for liver cancer," said Dr. Sean Altekruse, an Epidemiologist with the NCI's SEER Program and the study's lead author. "Additional research into the factors related to this increase in incidence will be vital to preventing these rates from rising further." Dr. Altekruse noted that heavy alcohol consumption, fatty liver disease, obesity, diabetes mellitus and iron storage diseases may also contribute to the increasing incidence of liver cancer.

The study found that between 1975 and 2005, liver cancer rates tripled, from 1.6 cases per 100,000 people to 4.9 per 100,000. From 1992 to 2005, liver cancer incidence trends increased significantly:

  • African-Americans and Hispanics both experienced an approximately 67 percent increase in liver cancer incidence between 1992 and 2005 (4.2 to 7.0/100,000 and 4.8 to 8.0/100,000, respectively), and whites experienced an approximately 50 percent increase in incidence (2.6 to 3.9/100,000) during this time period.

  • Between 2000 and 2005, incidence rates increased most markedly among African-American men (42 percent, 28.7 to 40.8/100,000), Hispanic men (43 percent, 23 to 32.8/100,000), and white men (43 percent, (11.5 to 16.5/100,000) 50 to 59 years of age. These increases may be partially due to an epidemic of hepatitis C infection that began in the 1960s, when men in this age range were young adults.

  • From 1992 to 2005, liver cancer incidence rates among Asians and Pacific Islanders were the highest of all racial groups overall; however, rates increased by a relatively modest 17 percent (10.0 to 11.7/100,000) in this time period. Researchers attribute a substantial portion of liver cancer cases in Asians and Pacific Islanders to higher rates of hepatitis B among some Asian subgroups.

One-year survival rates nearly doubled between 1992 and 2005, rising from 25 percent of patients to 47 percent. Dr. Altekruse points out that while the increasing survival rates are encouraging, further improvement is still needed, noting that one-year survival rates are still below 50 percent.

ASCO Perspective
Jennifer Obel, ASCO official and Attending Physician, NorthShore University HealthSystem

"Early screening for patients with hepatitis C, a leading risk factor for liver cancer, has directly contributed to increasing survival rates for patients living with liver cancer. When detected early, there are significantly more treatment options for liver cancer in most cases, the earlier it is caught, the better the prognosis. This study points to the need to identify even more at-risk individuals through early screening programs to improve prognosis with potentially curative therapy."


Contact: Kelly Powell
American Society of Clinical Oncology

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
3. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
4. Takeda statement on ACTOS meta-analysis published in the Journal of the American Medical Association
5. Takeda Statement on ACTOS(R) (Pioglitazone HCl) Meta-Analysis Published in the Journal of the American Medical Association
6. Physical Therapist Provides Injury Analysis for Fantasy Football
7. Sanofi-Aventis renews licenses for Genomatix chip analysis pipeline
8. Meta-Analysis of Blood Phe Levels and Clinical Outcomes in PKU Published
9. OCS and Press Ganey Partner to Create Joint Analysis of Outcomes and Satisfaction
10. New Analysis Underscores Legality of Physician Ranking and Public Reporting Systems When Used by Health Insurers to Improve Health Care Quality
11. Barta joins Conseco as Senior Vice President, Financial Planning & Analysis; Barra named Senior Vice President, Internal Audit; Clarke to head Investor Relations
Post Your Comments:
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released ... failing their residents by lacking a comprehensive, proven plan to eliminate ... a definitive ranking of how states are tackling the worst drug ... only four states – Kentucky , ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology: