Navigation Links
New agent chokes off energy supply, kills cancer cells
Date:4/7/2010

COLUMBUS, Ohio Cancer cells grow so fast that they can outstrip their blood supply, leaving them short of oxygen. The cells then produce energy in a way that needs less oxygen but more sugar.

Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have designed an experimental drug that chokes off that sugar supply, causing the cells to self destruct.

The agent, called OSU-CG12, is an example of a new class of anticancer drugs called energy-restriction mimetic agents. It is described in a paper published recently in the Journal of Biological Chemistry.

"Energy restriction may offer a powerful new strategy for treating cancer because it targets a survival mechanism used by many types of cancer," says principal investigator Ching-Shih Chen, professor of medicinal chemistry, of internal medicine and of urology.

"Our study proves that this new agent kills cancer cells through energy restriction. This is important because it shows that it is possible to design drugs that target energy restriction, and it is exciting because energy-restricting mimetic agents may also be useful for other diseases, including metabolic syndromes, diabetes, cardiovascular disease and obesity," Chen adds.

Energy-restricting mimetic agents cause changes in cancer cells that are similar to those that occur in cancer cells deprived of their main energy source, the sugar glucose.

To design the new agent, Chen and his collaborators started with a drug called ciglitazone, which had been developed to treat type II diabetes but also showed anticancer activity in laboratory experiments.

That original drug produced its anti-diabetic effects by activating a protein called PPAR-gamma and a number of genes. The same mechanism was thought responsible for the drug's anticancer effects. Chen and his colleagues showed, however, that the anticancer effects were due to a different mechanism, one involving energy restriction.

To enhance that activity, they altered the structure of the ciglitazone molecule, producing OSU-CG12. Using prostate cancer and breast cancer cell lines, they showed that the new Ohio State agent was 10 times better at killing cancer cells than ciglitazone and a second agent, the drug resveratrol, a natural product found in grapes and red wine that has weak anticancer activity and also works through energy restriction.

Furthermore, they showed that the new agent both stops glucose from entering cancer cells and suppresses the cells' ability to metabolize the sugar.

Starved for fuel, the cancer cells begin consuming themselves, a process called autophagy self eating accompanied by other biochemical events that lead to the cells' death by a natural process called apoptosis.

Chen and his colleagues continue modifying OSU-CG12 to enhance its efficacy. They also hope to test the agent in other conditions such as cardiovascular disease and Alzheimer's disease.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Targeted agent blocked growth of deadly brain cancer in preclinical studies
2. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
3. Overcoming tumor resistance to anti-cancer agent TRAIL
4. Professional Insurance Agents Name Rep. Charlie Melancon 2010 Legislator of the Year
5. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
6. Professional Insurance Agents to Hold 2010 Federal Legislative Summit March 17-18
7. Cleaning Agent Tied to Parkinsons in Study
8. News brief: Contrast agent with MRI improves detection of lymph nodes metastases
9. Contact Center Compliance Launches New Sales Agent Productivity Tool: "SmartBlock (TM)"
10. CRE Secure Simplifies PCI Compliance for Magento Shopping Cart Online Merchants
11. Medical Travel Quality Alliance to Certify Medical Tourism Agents for Safer, Quality Health Care for Traveling International Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... , ... May 25, 2016 , ... According to an ... type of hernia mesh that would effectively fight against common bacteria and protect against ... the healing process from hernia repair surgery even safer and could further ...
(Date:5/25/2016)... ... 25, 2016 , ... The Horizon Foundation for New Jersey ... to improve oral health-related awareness, education, prevention and treatment for young people. The ... promote best practices in 10 New Jersey counties where dental health needs among ...
(Date:5/25/2016)... ... , ... The Bank of America Charitable Foundation has awarded a grant to ... pathway to employment and successful careers in healthcare. On Wednesday, May 4th, Rick Bridwell, ... CEO of Medisend, parent organization and home of the General Myers Veterans Program. ...
(Date:5/25/2016)... ... 25, 2016 , ... Today American University of Antigua (AUA) ... announced the AUA-FIU Global MD Program. Students in the Global MD Program ... a Certificate of Completion from the FIU Herbert Wertheim College of Medicine Clinical ...
(Date:5/25/2016)... ... May 25, 2016 , ... Dr. Travis Schwarz is an experienced dentist who ... O’Fallon, MO 63366. He serves patients of all ages with a full menu of ... success is reflected in the superior patient reviews that he has consistently earned during ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 The innovator ... , s first dual therapy stent, introduces ... OrbusNeich, a global company specializing in the ... to include products to treat peripheral artery disease. The ... entry devices for lower limb and arteriovenous (AV) fistula ...
(Date:5/24/2016)... , May 24, 2016 Een ... verbindt, zodat zij collectief patiënten kunnen behandelen, hun kennis ... het idee achter de nieuwe en revolutionaire MDLinking App, ... de Nederlandse vaatchirurg dr. Hans Flu en oncologisch chirurg ... die inmiddels beschikbaar is, wordt op dinsdag 24 mei ...
(Date:5/23/2016)... , May 23, 2016 ... Market Size, Share, Development, Growth and Demand Forecast ... Single and Other), by Application (Drug Discovery and ... End Users (Pharmaceuticals, Life Science and Biotechnology, Academic ... P&S Market Research, the global mass spectrometry ...
Breaking Medicine Technology: