Navigation Links
New agent chokes off energy supply, kills cancer cells
Date:4/7/2010

COLUMBUS, Ohio Cancer cells grow so fast that they can outstrip their blood supply, leaving them short of oxygen. The cells then produce energy in a way that needs less oxygen but more sugar.

Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have designed an experimental drug that chokes off that sugar supply, causing the cells to self destruct.

The agent, called OSU-CG12, is an example of a new class of anticancer drugs called energy-restriction mimetic agents. It is described in a paper published recently in the Journal of Biological Chemistry.

"Energy restriction may offer a powerful new strategy for treating cancer because it targets a survival mechanism used by many types of cancer," says principal investigator Ching-Shih Chen, professor of medicinal chemistry, of internal medicine and of urology.

"Our study proves that this new agent kills cancer cells through energy restriction. This is important because it shows that it is possible to design drugs that target energy restriction, and it is exciting because energy-restricting mimetic agents may also be useful for other diseases, including metabolic syndromes, diabetes, cardiovascular disease and obesity," Chen adds.

Energy-restricting mimetic agents cause changes in cancer cells that are similar to those that occur in cancer cells deprived of their main energy source, the sugar glucose.

To design the new agent, Chen and his collaborators started with a drug called ciglitazone, which had been developed to treat type II diabetes but also showed anticancer activity in laboratory experiments.

That original drug produced its anti-diabetic effects by activating a protein called PPAR-gamma and a number of genes. The same mechanism was thought responsible for the drug's anticancer effects. Chen and his colleagues showed, however, that the anticancer effects were due to a differ
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted agent blocked growth of deadly brain cancer in preclinical studies
2. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
3. Overcoming tumor resistance to anti-cancer agent TRAIL
4. Professional Insurance Agents Name Rep. Charlie Melancon 2010 Legislator of the Year
5. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
6. Professional Insurance Agents to Hold 2010 Federal Legislative Summit March 17-18
7. Cleaning Agent Tied to Parkinsons in Study
8. News brief: Contrast agent with MRI improves detection of lymph nodes metastases
9. Contact Center Compliance Launches New Sales Agent Productivity Tool: "SmartBlock (TM)"
10. CRE Secure Simplifies PCI Compliance for Magento Shopping Cart Online Merchants
11. Medical Travel Quality Alliance to Certify Medical Tourism Agents for Safer, Quality Health Care for Traveling International Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... of Bioengineering and Nanotechnology (IBN), Singapore General Hospital ... co-developed the first molecular test kit that can ... patients. This breakthrough was recently reported in ... , According to IBN Executive Director Professor ... molecular diagnostics and cancer research, we have developed ...
(Date:8/1/2014)... Beach, FL (PRWEB) August 01, 2014 ... announced today the opening of a new K-CAPS® ... , The company announced expansion plans last year ... According to Dale Martin, General Manager, “KCAPS® are ... the world.” He added that: “Compared to other ...
(Date:8/1/2014)... Hills, CA (PRWEB) August 01, 2014 ... has found that carbohydrates may contribute to the ... genetically predisposed to the disease. The study was authored ... it, carbohydrates were found to cause intestinal cells to ... more susceptible to colorectal cancer. , “What’s interesting ...
(Date:8/1/2014)... (PRWEB) August 01, 2014 This week ... who completes its 500th week of paying commissions to ... company was founded in January 2005 total $1,405,954,677.06. , ... the world. The company pays commissions in 18 different ... JPY, MYR, MXN, NZD, PLN, USD, SGD, KRW, TWD, ...
(Date:8/1/2014)... A leading dress supplier, Discount-Dress.com, explores a variety of outfits ... lady’s wardrobe fashionable and exciting. Recently, the company has announced ... attract more people, it is now launching a special offer ... 65% off. , “Summer is the season of short bridesmaid ... our collection of ‘ 2014 summer short styles .’ The ...
Breaking Medicine News(10 mins):Health News:Taking the guesswork out of cancer therapy 2Health News:Taking the guesswork out of cancer therapy 3Health News:Carbs May Contribute to Colon Cancer 2Health News:MonaVie Records 500th Commission Week, Having Paid Out More Than $1.4B in Distributor Commissions 2Health News:Discount-Dress.com’s Top Trend Report: 2014 Summer Short Bridesmaid Dresses Now for Sale 2
... Order to Remain ... Competitive, COLUMBUS, Ohio, ... healthcare costs for families since 2000, small,business owners across the country are ... workers and for the,business., In response to what is becoming a ...
... Oct. 21 Isolagen(TM), Inc. (Amex:,ILE) announced today ... Phase,II/III Study IT-A-008 investigating Isolagen Therapy(TM) for the ... approximately half of all,of the study participants have ... study will conclude in the first quarter of,2009., ...
... says , , TUESDAY, Oct. 21 (HealthDay News) -- Having ... job may help protect against the memory loss that ... It included 242 people with Alzheimer,s, 72 with mild ... with mild cognitive impairment have memory problems beyond what,s ...
... white women at increasing risk, study finds , , TUESDAY, Oct. ... States is increasing for the first time in a decade, ... "This is a group we haven,t had as much focus ... higher in elderly white males, and there has been a ...
... Norway, Oct. 21 Do you feel there must be,more ... In his new,self-help book, "True Love: the meaning of life" ... you,ve ever,wondered about true love: what it is, what it ... now holding a complete step-by-step guide describing how to,achieve true ...
... Bulletin Board: NTRZ), a,world leader in stabilized rice ... world champion powerlifter Mike Bridges,received four gold medals ... dead lift events and was named World Champion ... World Powerlifting Championships in Palm,Springs, CA. Bridges points ...
Cached Medicine News:Health News:Huntington Bank Offers Tips to Help Small Businesses Reduce Healthcare Costs 2Health News:Huntington Bank Offers Tips to Help Small Businesses Reduce Healthcare Costs 3Health News:Isolagen Inc. Completes Injections of Isolagen Therapy(TM) in Phase II/III Acne Scar Study 2Health News:Isolagen Inc. Completes Injections of Isolagen Therapy(TM) in Phase II/III Acne Scar Study 3Health News:Job, Education May Buffer Against Dementia 2Health News:Suicide Rates Rise Among Baby Boomers 2Health News:Suicide Rates Rise Among Baby Boomers 3Health News:'True Love: the meaning of life': Learn What True Love Is and How to Find It in Revealing Self-Help Book 2Health News:Mike Bridges Takes Home Four Gold Medals at IPF Masters World Powerlifting Championships; Says NutraCea's RiSolubles(R) is an Essential Part of his Training Regimen 2Health News:Mike Bridges Takes Home Four Gold Medals at IPF Masters World Powerlifting Championships; Says NutraCea's RiSolubles(R) is an Essential Part of his Training Regimen 3
(Date:8/1/2014)... Aug. 1, 2014 MGC Diagnostics Corporation ... announced today that it has completed its acquisition ... cardiorespiratory diagnostic products based in Sorinnes, ... the European cardiorespiratory diagnostics market since 1977. MediSoft, ... approximately €4.7 million ($6.3 million) and incurred a ...
(Date:8/1/2014)... LAWRENCE, Mass. , Aug. 1, 2014  NxStage Medical, ... innovative dialysis products, today announced that Jeffrey H. Burbank ... Financial Officer, will present at the 34 th Annual ... Boston, MA , on Wednesday, August 13 ... event will be made available at http://ir.nxstage.com/ .  ...
(Date:8/1/2014)...  Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ) ... study evaluating ISIS-SMN Rx in infants with spinal ... infant mortality. Isis plans to dose the first infant ... which time Isis will earn an $18 million milestone ... 3 study, ENDEAR, is the first of several planned ...
Breaking Medicine Technology:MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 3MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 4NxStage to Present at the 34th Annual Canaccord Genuity Growth Conference 2Isis Pharmaceuticals Initiates Phase 3 Study of ISIS-SMN Rx in Infants with Spinal Muscular Atrophy 2Isis Pharmaceuticals Initiates Phase 3 Study of ISIS-SMN Rx in Infants with Spinal Muscular Atrophy 3Isis Pharmaceuticals Initiates Phase 3 Study of ISIS-SMN Rx in Infants with Spinal Muscular Atrophy 4Isis Pharmaceuticals Initiates Phase 3 Study of ISIS-SMN Rx in Infants with Spinal Muscular Atrophy 5
... College of American Pathologists Outlines Recommendations at Food and Drug ... , ... increasing importance of laboratory tests in diagnosing and treating disease, representatives ... the Food and Drug Administration (FDA) urging increased oversight of laboratory ...
... CHICAGO and PASADENA, Calif. , July 20 ... that Huntington Memorial Hospital has selected the Allscripts ... Exchange (HIE) that enables physicians, hospitals and other health care providers ... team approach to patient care, regardless of where they are located ...
Cached Medicine Technology:CAP Leaders Stress Need for Oversight of Direct-to-Consumer and Laboratory Developed Tests 2CAP Leaders Stress Need for Oversight of Direct-to-Consumer and Laboratory Developed Tests 3CAP Leaders Stress Need for Oversight of Direct-to-Consumer and Laboratory Developed Tests 4Huntington Memorial Hospital Selects Allscripts Community Solution to Create a Connected, Collaborative Health Community 2Huntington Memorial Hospital Selects Allscripts Community Solution to Create a Connected, Collaborative Health Community 3Huntington Memorial Hospital Selects Allscripts Community Solution to Create a Connected, Collaborative Health Community 4Huntington Memorial Hospital Selects Allscripts Community Solution to Create a Connected, Collaborative Health Community 5Huntington Memorial Hospital Selects Allscripts Community Solution to Create a Connected, Collaborative Health Community 6Huntington Memorial Hospital Selects Allscripts Community Solution to Create a Connected, Collaborative Health Community 7
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... up kit. Includes configured Laptop PC with ... 1 MultiBlock satellite thermal Cycler (non-robotic). ... friendly software. Store/track run data. ... Outstanding uniformity. Advanced control algorithms ...
PxE thermal Cycler. 0.5ml block holds 48 0.5 ml tubes or 96 0.3 ml tubes. Adjustable height heated lid. Outstanding uniformity. Advanced control algorithms for reduced reaction times. User frien...
PxE thermal Cycler. 0.2ml, 96 well block holds 96 tubes or 1 x 96 well plate. Adjustable height heated lid. Outstanding uniformity. Advanced control algorithms for reduced reaction times. User f...
Medicine Products: