Navigation Links
New activity found for a potential anti-cancer agent
Date:11/2/2009

Pateamine A (PatA), a natural product first isolated from marine sponges, has attracted considerable attention as a potential anti-cancer agent, and now a new activity has been found for it, which may reveal yet another anti-cancer mechanism. That's the assessment of Daniel Romo, a Texas A&M chemistry professor, and his colleagues at Johns Hopkins University who are pioneers in research involving this novel marine natural product.

Messenger RNA (mRNA), as its name indicates, copies messages from genes on DNA and uses these messages to produce proteins, and the human body functions well only with the right types and amount of proteins. So, what happens when mRNA gets damaged? Will the wrong proteins produced by the wrong messages carried by mRNA damage a person's body?

Don't worry it's under surveillance, and PatA has been found to inhibit one such surveillance mechanism called NMD, Romo says.

NMD stands for nonsense-mediated mRNA decay, a key mechanism in the cell to degrade damaged and not fully functional mRNA. NMD watches inside the body 24 hours a day, and whenever damaged mRNA is found, NMD attaches a "bad-mRNA" tag on it and summons an army to destroy it.

However, with cancer cells, inhibition of NMD is desirable.

"We found that PatA and a simplified, easier to synthesize derivative of PatA called desmethyl,desamino-PatA (DMDAPatA) inhibit NMD," the Texas A&M professor says. "This may contribute to the apoptosis (suicide) of tumor cells."

Romo and colleagues from Johns Hopkins University School of Medicine, University of Heidelberg and European Molecular Biology Laboratory published their recent findings in the Journal of Biological Chemistry.

Romo is no stranger to PatA. He began to work on its synthesis more than a decade ago. In 1998, the Texas A&M professor's group achieved the first laboratory synthesis of PatA, and, in 2005, using a PatA conjugate, his collaborator, professor Jun O. Liu at Johns Hopkins, found that PatA inhibits the initiation phase of protein synthesis, which gives PatA the potential to fight cancer.

"Tumor cells are more actively producing new proteins than normal cells, so tumor cells are hundreds if not thousands of times more vulnerable to DMDAPatA's inhibition of protein synthesis, which makes DMDAPatA a good candidate as an anti-cancer agent," he explains.

"DMDAPatA is structurally simpler than PatA but exhibits similar activity in inhibiting NMD and protein synthesis," Romo notes. "It has been patented by Texas A&M, evaluated by two pharmaceutical companies, and continues to be evaluated as a potential anti-cancer agent for both human and animal (pet) applications."


'/>"/>

Contact: Daniel Romo
romo@tamu.edu
979-845-9571
Texas A&M University
Source:Eurekalert

Related medicine news :

1. Nuvo Research responds to increased trading activity
2. Physical activity in adolescence associated with decreased risk of brain cancer in adulthood
3. M&A Activity on the Increase, According to BusinessesForSale.com
4. Short-term stress enhances anti-tumor activity in mice, Stanford study shows
5. Genetics Linked to Early Sexual Activity in Kids
6. K-State Veterinarian Says Dog Owners Can Make Themselves, Their Pets Healthier With Physical Activity Based on Dogs Specific Needs, Interests
7. Finding may explain anti-cancer activity of thiazole antibiotics
8. Researchers find alcoholics display abnormal brain activity when processing facial expressions
9. Mental Activity Seems to Keep the Brain Vital
10. VivaGel(R) Demonstrates Anti-HIV and Herpes Activity Following Human Administration
11. National Health Information Exchange Survey Shows Increased Activity, Cost Savings, Positive Impact on Physician Practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s ... June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... helping service members that have been wounded in battle and their families. Venture Construction ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Surgical Procedure Volumes: Global Analysis (United States, China, Japan, ... report to their offering. ... tool for healthcare business planners, provides surgical procedure volume ... surgery trends with an in-depth analysis of growth drivers ...
Breaking Medicine Technology: