Navigation Links
New activity found for a potential anti-cancer agent
Date:11/2/2009

Pateamine A (PatA), a natural product first isolated from marine sponges, has attracted considerable attention as a potential anti-cancer agent, and now a new activity has been found for it, which may reveal yet another anti-cancer mechanism. That's the assessment of Daniel Romo, a Texas A&M chemistry professor, and his colleagues at Johns Hopkins University who are pioneers in research involving this novel marine natural product.

Messenger RNA (mRNA), as its name indicates, copies messages from genes on DNA and uses these messages to produce proteins, and the human body functions well only with the right types and amount of proteins. So, what happens when mRNA gets damaged? Will the wrong proteins produced by the wrong messages carried by mRNA damage a person's body?

Don't worry it's under surveillance, and PatA has been found to inhibit one such surveillance mechanism called NMD, Romo says.

NMD stands for nonsense-mediated mRNA decay, a key mechanism in the cell to degrade damaged and not fully functional mRNA. NMD watches inside the body 24 hours a day, and whenever damaged mRNA is found, NMD attaches a "bad-mRNA" tag on it and summons an army to destroy it.

However, with cancer cells, inhibition of NMD is desirable.

"We found that PatA and a simplified, easier to synthesize derivative of PatA called desmethyl,desamino-PatA (DMDAPatA) inhibit NMD," the Texas A&M professor says. "This may contribute to the apoptosis (suicide) of tumor cells."

Romo and colleagues from Johns Hopkins University School of Medicine, University of Heidelberg and European Molecular Biology Laboratory published their recent findings in the Journal of Biological Chemistry.

Romo is no stranger to PatA. He began to work on its synthesis more than a decade ago. In 1998, the Texas A&M professor's group achieved the first laboratory synthesis of PatA, and, in 2005, using a PatA conjugate, his collaborator, professor Jun O. Liu at Johns Hopkins, found that PatA inhibits the initiation phase of protein synthesis, which gives PatA the potential to fight cancer.

"Tumor cells are more actively producing new proteins than normal cells, so tumor cells are hundreds if not thousands of times more vulnerable to DMDAPatA's inhibition of protein synthesis, which makes DMDAPatA a good candidate as an anti-cancer agent," he explains.

"DMDAPatA is structurally simpler than PatA but exhibits similar activity in inhibiting NMD and protein synthesis," Romo notes. "It has been patented by Texas A&M, evaluated by two pharmaceutical companies, and continues to be evaluated as a potential anti-cancer agent for both human and animal (pet) applications."


'/>"/>

Contact: Daniel Romo
romo@tamu.edu
979-845-9571
Texas A&M University
Source:Eurekalert

Related medicine news :

1. Nuvo Research responds to increased trading activity
2. Physical activity in adolescence associated with decreased risk of brain cancer in adulthood
3. M&A Activity on the Increase, According to BusinessesForSale.com
4. Short-term stress enhances anti-tumor activity in mice, Stanford study shows
5. Genetics Linked to Early Sexual Activity in Kids
6. K-State Veterinarian Says Dog Owners Can Make Themselves, Their Pets Healthier With Physical Activity Based on Dogs Specific Needs, Interests
7. Finding may explain anti-cancer activity of thiazole antibiotics
8. Researchers find alcoholics display abnormal brain activity when processing facial expressions
9. Mental Activity Seems to Keep the Brain Vital
10. VivaGel(R) Demonstrates Anti-HIV and Herpes Activity Following Human Administration
11. National Health Information Exchange Survey Shows Increased Activity, Cost Savings, Positive Impact on Physician Practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... Antonio, TX (PRWEB) , ... February 12, 2016 , ... ... love, as expressed in Blue SKies Buddha, the biography of Rama - Dr. Frederick ... fact a love story, the love of a Buddhist teacher for teaching and helping ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Lymphoma Research ... lymphoma research and serving the lymphoma community through a comprehensive series of education ... Florida’s philanthropic community at its 10th anniversary Fashion Luncheon on Monday, February 8, ...
(Date:2/12/2016)... Middletown, PA (PRWEB) , ... February 12, 2016 , ... ... year’s event will be held in Anaheim, CA at the Anaheim Convention Center. Almost ... they can see new therapy products in action, learn more about their chosen field ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... firm announced that nominations have closed for the ISE Southeast Awards 2016. Finalists ... be announced at the ISE® Southeast Executive Forum and Awards Gala on March ...
(Date:2/12/2016)... ... 12, 2016 , ... Every winter, someone is killed, injured or loses a ... Burn Center, part of the Allegheny Health Network, has partnered with Etna Volunteer ... Heaters Need Space” campaign. , “Space Heaters Need Space” aims to bring ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... SAN JOSE, Calif. , Feb. 12, 2016  SI-BONE, Inc., ... Implant System ® ("iFuse"), a minimally invasive surgical (MIS) device ... announced that National Government Services, Inc. (NGS), the Medicare Administrative Contractor ... Illinois , Maine , ... Hampshire , New York , ...
(Date:2/12/2016)... , Feb. 12, 2016 On Thursday, Feb. ... Surgery at St. David,s North Austin Medical Center successfully ... ® Xi ® Surgical System with Trumpf ... Thiru Lakshman , M.D., colorectal surgeon at ... proctocolectomy utilizing Integrated Table Motion technology, which seamlessly combines ...
(Date:2/12/2016)... BUFORD, Ga. , Feb. 12 2016  OMS ... office-based dental and medical practitioners, announced today the recent ... website offers visitors a variety of features that enhance ... purchase oral surgery supplies. --> ... Supply is a fairly new company that started in ...
Breaking Medicine Technology: