Navigation Links
New activity found for a potential anti-cancer agent
Date:11/2/2009

Pateamine A (PatA), a natural product first isolated from marine sponges, has attracted considerable attention as a potential anti-cancer agent, and now a new activity has been found for it, which may reveal yet another anti-cancer mechanism. That's the assessment of Daniel Romo, a Texas A&M chemistry professor, and his colleagues at Johns Hopkins University who are pioneers in research involving this novel marine natural product.

Messenger RNA (mRNA), as its name indicates, copies messages from genes on DNA and uses these messages to produce proteins, and the human body functions well only with the right types and amount of proteins. So, what happens when mRNA gets damaged? Will the wrong proteins produced by the wrong messages carried by mRNA damage a person's body?

Don't worry it's under surveillance, and PatA has been found to inhibit one such surveillance mechanism called NMD, Romo says.

NMD stands for nonsense-mediated mRNA decay, a key mechanism in the cell to degrade damaged and not fully functional mRNA. NMD watches inside the body 24 hours a day, and whenever damaged mRNA is found, NMD attaches a "bad-mRNA" tag on it and summons an army to destroy it.

However, with cancer cells, inhibition of NMD is desirable.

"We found that PatA and a simplified, easier to synthesize derivative of PatA called desmethyl,desamino-PatA (DMDAPatA) inhibit NMD," the Texas A&M professor says. "This may contribute to the apoptosis (suicide) of tumor cells."

Romo and colleagues from Johns Hopkins University School of Medicine, University of Heidelberg and European Molecular Biology Laboratory published their recent findings in the Journal of Biological Chemistry.

Romo is no stranger to PatA. He began to work on its synthesis more than a decade ago. In 1998, the Texas A&M professor's group achieved the first laboratory synthesis of PatA, and, in 2005, using a PatA conjugate, his collaborator, professor Jun O. L
'/>"/>

Contact: Daniel Romo
romo@tamu.edu
979-845-9571
Texas A&M University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nuvo Research responds to increased trading activity
2. Physical activity in adolescence associated with decreased risk of brain cancer in adulthood
3. M&A Activity on the Increase, According to BusinessesForSale.com
4. Short-term stress enhances anti-tumor activity in mice, Stanford study shows
5. Genetics Linked to Early Sexual Activity in Kids
6. K-State Veterinarian Says Dog Owners Can Make Themselves, Their Pets Healthier With Physical Activity Based on Dogs Specific Needs, Interests
7. Finding may explain anti-cancer activity of thiazole antibiotics
8. Researchers find alcoholics display abnormal brain activity when processing facial expressions
9. Mental Activity Seems to Keep the Brain Vital
10. VivaGel(R) Demonstrates Anti-HIV and Herpes Activity Following Human Administration
11. National Health Information Exchange Survey Shows Increased Activity, Cost Savings, Positive Impact on Physician Practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 2014 Chromatography system is a ... various types of biological samples such as air ... mixture into two phase, namely mobile phase and ... run over the stationary phase, followed by the ... provide the separation of mixture. Chromatography system plays ...
(Date:7/13/2014)... Micro irrigation systems are mainly utilized for agriculture ... as to maintain soil quality. The application of micro ... dominant revenue generator for manufacturers in future. The trend ... has led to the adoption of micro irrigation techniques ... massive demand for micro irrigation systems, as they reduce ...
(Date:7/13/2014)... According to a new market research report "Heterogeneous ... GPU, DSP, connectivity), Technology Node (45nm-5nm), Application (Consumer, ... and Analysis to 2014-2020", published by MarketsandMarkets, the ... expected to reach $61.70 Billion by 2020, growing ... 2020. , Browse 71 market data Tables with ...
(Date:7/13/2014)... Houston, TX (PRWEB) July 13, 2014 The ... for children ranging in age from four months to 12 ... skills and karate classes to birthday parties and Summer Camps, ... the Little Gym of Pearland after spending over ... variety of roles, including Gym Director. , Berry has ...
(Date:7/13/2014)... Rico (PRWEB) July 13, 2014 ... of Famer, Chris Mullin, will be the featured guest ... July 26th in Puerto Rico. Attendees will learn ... will participate in two exhibition basketball games and perform ... ultimate supplier of health- and energy-boosting supplements , ...
Breaking Medicine News(10 mins):Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 2Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 3Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 3Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 4
... body,s sleep-wake system ,can,t remember anything, study says , , ... may do more than help guide your daily sleep/wake ... in learning and memory, say Stanford University researchers. , ... circadian system is critical to the rodents, ability to ...
... VIPER RESPONDER LE SPECIAL ... REMOTE START SYSTEM, VISTA, Calif., Oct. 13 Directed ... ), has joined,the fight against breast cancer with the availability ... systems from Viper,supporting Susan G. Komen for the Cure. For ...
... to Get Tested, LOS ANGELES, Oct. 13 , ... of all newly diagnosed HIV/AIDS cases,reported in Los Angeles ... week of activities aimed at raising awareness and encouraging ... Awareness Day,observed on October 15., -- October 14, ...
... No interruption to shipments or service to new ... Cardiac Science,Corporation (Nasdaq: CSCX ) announced ... corrective action of certain automated external,defibrillators (AEDs) manufactured ... in this time frame may have a component ...
... ever before, study finds , , MONDAY, Oct. 13 (HealthDay ... for high blood pressure, say researchers from the U.S. ... factor in the dramatic increase in the number of ... obesity epidemic rife in the United States, they noted. ...
... of six sites included in national study ... cardiac arrest survival rates, OSHKOSH, Wis., Oct. 13 ... that it has,received an additional $1.5 million in funding ... study testing two devices used in combination,on those who ...
Cached Medicine News:Health News:Circadian Rhythm Plays Role in Memory 2Health News:Supporting Susan G. Komen for the Cure(R) During National Breast Cancer Awareness Month 2Health News:Supporting Susan G. Komen for the Cure(R) During National Breast Cancer Awareness Month 3Health News:Nearly Half of Newly Diagnosed HIV/AIDS Cases in Los Angeles County Are Among Latinos 2Health News:Cardiac Science Initiates Voluntary Field Corrective Action of Certain AEDs 2Health News:Cardiac Science Initiates Voluntary Field Corrective Action of Certain AEDs 3Health News:Blood Pressure on the Rise in America 2Health News:Blood Pressure on the Rise in America 3Health News:Advanced Circulatory Systems Receives $1.5 Million From NIH for Study of Cardiac Arrest Resuscitation Techniques 2
(Date:7/10/2014)... Yesterday, former Congressman Patrick Kennedy ... facility. Rep. Kennedy and Dick Moberg ... research in neurological disease and treatment. ... Garen Staglin , created One Mind, a ... that will radically accelerate the development and implementation ...
(Date:7/10/2014)... Ariz. , July 10, 2014   Ventana ...  Group, today announced it has entered into an agreement ... which operates as EMD Serono in the ... , to collaborate with Merck KGaA,s biopharmaceutical division on ... for an undisclosed target using Ventana,s proprietary diagnostic assays. ...
(Date:7/10/2014)... CVS Caremark Corporation (NYSE: CVS ) today announced ... of $0.275 (27.5 cents) per share on the corporation,s common ... holders of record on July 21, 2014. About ... helping people on their path to better health as the ... . Through the company,s more than 7,600 CVS/pharmacy stores; ...
Breaking Medicine Technology:Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... BOSTON , June 15 Solos Endoscopy, ... the Company has developed a relay lense adapter system ... the MammoView® scope and endocoupler to join with virtually ... now has the flexibility to market the MammoView® to ...
... N.J. , June 15 Access Communications, LLC (Access) has ... officer (CEO). Since mid-2009, Access was under the leadership of a group ... his responsibilities as chief financial officer (CFO). , ... "I am humbled and honored to be named ...
Cached Medicine Technology:Solos Endoscopy, Inc. Develops Relay Lense Adapter System For MammoView® Product Line 2New President and Chief Executive Officer Named at Access Communications, LLC 2New President and Chief Executive Officer Named at Access Communications, LLC 3
... ACULAR® ophthalmic solution is a prescription ... instruct you to use after your ... eyes and may cause them to ... symptoms of inflammation include redness and ...
... The ECG-9320 is a full-featured ... meets IEC60601-2-51 new international standard ... and digital filter performance. The ... and managed on a Windows ...
... meets IEC60601-2-51 new international standard ... and digital filter performance. It ... lightest 12 channel interpretive electrocardiograph.,It ... recorder records 3, 4, 6 ...
The Sonic WAVE™is the first market-ready Alternative to Ultrasound...
Medicine Products: