Navigation Links
New activity found for a potential anti-cancer agent
Date:11/2/2009

Pateamine A (PatA), a natural product first isolated from marine sponges, has attracted considerable attention as a potential anti-cancer agent, and now a new activity has been found for it, which may reveal yet another anti-cancer mechanism. That's the assessment of Daniel Romo, a Texas A&M chemistry professor, and his colleagues at Johns Hopkins University who are pioneers in research involving this novel marine natural product.

Messenger RNA (mRNA), as its name indicates, copies messages from genes on DNA and uses these messages to produce proteins, and the human body functions well only with the right types and amount of proteins. So, what happens when mRNA gets damaged? Will the wrong proteins produced by the wrong messages carried by mRNA damage a person's body?

Don't worry it's under surveillance, and PatA has been found to inhibit one such surveillance mechanism called NMD, Romo says.

NMD stands for nonsense-mediated mRNA decay, a key mechanism in the cell to degrade damaged and not fully functional mRNA. NMD watches inside the body 24 hours a day, and whenever damaged mRNA is found, NMD attaches a "bad-mRNA" tag on it and summons an army to destroy it.

However, with cancer cells, inhibition of NMD is desirable.

"We found that PatA and a simplified, easier to synthesize derivative of PatA called desmethyl,desamino-PatA (DMDAPatA) inhibit NMD," the Texas A&M professor says. "This may contribute to the apoptosis (suicide) of tumor cells."

Romo and colleagues from Johns Hopkins University School of Medicine, University of Heidelberg and European Molecular Biology Laboratory published their recent findings in the Journal of Biological Chemistry.

Romo is no stranger to PatA. He began to work on its synthesis more than a decade ago. In 1998, the Texas A&M professor's group achieved the first laboratory synthesis of PatA, and, in 2005, using a PatA conjugate, his collaborator, professor Jun O. L
'/>"/>

Contact: Daniel Romo
romo@tamu.edu
979-845-9571
Texas A&M University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nuvo Research responds to increased trading activity
2. Physical activity in adolescence associated with decreased risk of brain cancer in adulthood
3. M&A Activity on the Increase, According to BusinessesForSale.com
4. Short-term stress enhances anti-tumor activity in mice, Stanford study shows
5. Genetics Linked to Early Sexual Activity in Kids
6. K-State Veterinarian Says Dog Owners Can Make Themselves, Their Pets Healthier With Physical Activity Based on Dogs Specific Needs, Interests
7. Finding may explain anti-cancer activity of thiazole antibiotics
8. Researchers find alcoholics display abnormal brain activity when processing facial expressions
9. Mental Activity Seems to Keep the Brain Vital
10. VivaGel(R) Demonstrates Anti-HIV and Herpes Activity Following Human Administration
11. National Health Information Exchange Survey Shows Increased Activity, Cost Savings, Positive Impact on Physician Practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... Danvers, MA (PRWEB) April 21, 2015 ... managed mobility services, has been recognized by the Boston ... Massachusetts. The ranking was announced at a recent ... Journal’s annual list of the fastest-growing private companies in ... held businesses in the state that recorded the fastest ...
(Date:4/21/2015)... The report “Dermatitis – ... on the therapeutic development for Dermatitis. ... new targets and MOAs to produce first-in-class ... is available @ http://www.rnrmarketresearch.com/dermatitis-pipeline-review-h1-2015-market-report.html . ... involved in the therapeutic development for Dermatitis ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 Edward ... and Arthur “A.G.” Kawamura, former Secretary of the California ... featured speakers for the 2nd Annual GrowRIVERSIDE Conference: The ... , The inclusion of these nationally known experts ... experts, city planners, farmers and others slated to speak ...
(Date:4/21/2015)... Chicago, IL (PRWEB) April 21, 2015 ... the online retailer known for innovation at its healthiest, ... supplements starting May 1st. , At Wojo Nutrition, they’ve ... health seekers with convenient solutions tailored to meet their ... designed to be blended with any beverage, has been ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Carinsuranceshoppingsource.com ... of analyzing comprehensive auto insurance plans . ... it provides coverage for numerous situations. The coverage limit ... expensive. Comprehensive auto insurance will protect a car against ... , Comparing quotes is no longer difficult and ...
Breaking Medicine News(10 mins):Health News:Wireless Analytics Ranked as 25th Fastest Growing Private Company in Massachusetts 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 4Health News:USDA Under Secretary, former CA Agriculture Director to Address 2nd Annual “GrowRIVERSIDE” Conference in June 2Health News:USDA Under Secretary, former CA Agriculture Director to Address 2nd Annual “GrowRIVERSIDE” Conference in June 3Health News:Wojo Nutrition Announces their Lines of Single Serving Liquid Vitamins will be Available for Purchase online at Abesmarket.com Beginning in May 2Health News:Comprehensive Auto Insurance Is An Important But Complex Policy 2
... supplying 150,000 HIV sufferers with free anti-retroviral drugs by the end ... on Monday . ,"We are close to 110,000 people ... of December when we launch a massive scale-up of the drugs" ... increase would be underwritten by a new batch of funding from ...
... bird flu at the weekend, taking the death toll in the ... official said Monday . ,Indonesia has seen its toll ... first confirmed human deaths occurred here. ,"A boy who ... being positively infected," Ningrum, from the ministry's National Bird Flu Information ...
... Dengue fever killed 30 people in Myanmar in the first six ... latest country in the region to experience a surge in ... ministry official, told the weekly Myanmar Times newspaper that the number ... of this year there have been about 3,000 cases of the ...
... into a skin-care product that would wipe away wrinkles and ... ,The government's team of camel researchers, which has already pioneered ... found cosmetic properties in the hardy mammal's milk. ... a hospital's skin department to study it on 20 people ...
... Scientists at Childrens National Medical Center have demonstrated conclusively ... are instrumental in myelination and remyelination, processes essential to ... , This groundbreaking discovery in mouse models ... enhance healthy brain development and/or brain disease repair in ...
... will only make real breakthroughs in childrens medicine if they ... ,Professor John Warner was speaking today at the ... solely devoted to paediatric clinical research. ,The unit ... Marys Hospital, and it is based next to the hospitals ...
Cached Medicine News:Health News:Indonesia Confirms 81st Bird Flu Death 2Health News:Specific Protein is Instrumental in Myelination 2Health News:Specific Protein is Instrumental in Myelination 3Health News:Experts Need to Include Children in Research 2
(Date:4/21/2015)... YORK , April 21, 2015 EpiCast ... Summary Sepsis is a life-threatening complication arising from ... the infection damages its own tissues and organs. Anyone ... among children <1 year of age, older ... 2014). Global estimates for the year 2013 showed that ...
(Date:4/21/2015)... -- Inmark,s acquisition of Saf-T-Pak last week positioned Inmark ... Division 6.2.  For over 25 years, Saf-T-Pak has ... on IATA, ICAO, US DOT, Transport Canada, RID/ADR ... were particularly interested in Saf-T-Pak,s proprietary Learning Management ... programs," said David Oyler , Inmark President ...
(Date:4/21/2015)... , 21. April 2015  CorTechs ... die quantitative Analyse des Hirnvolumens freut sich, ... weltweiten Pharmaunternehmen, bekannt geben zu können. Die ... NeuroQuant-Quantifizierungsreports des Hirnvolumens zusammenarbeiten, der die Identifizierung, ... in Patienten mit multipler Sklerose als Ziel ...
Breaking Medicine Technology:EpiCast Report: Sepsis - Epidemiology Forecast to 2023 2EpiCast Report: Sepsis - Epidemiology Forecast to 2023 3Inmark's Acquisition Of Saf-T-Pak Results In Expansion Of Its Dangerous Goods Training Portfolio 2CorTechs Labs kündigt Partnerschaft für die Bereitstellung umfassender Lösungen zur Quantifizierung des Verlustes von Hirnvolumen bei multipler Sklerose an 2
... 1-step, hand-held, point-of-care device for the qualitative detection ... The TOX/See device can detect up to ... 3 to 8 minutes and requires only a ... individually packaged to maximize convenience and ease of ...
... is a whole blood formulation designed ... of the most popular glucose meters. ... using a control matrix that closely ... packaged in ready-to-use dropper vials with ...
... the laboratory to verify automatic pipets without purchasing ... Each PVS kit contains six vials of Receiver ... Solution. Using the pipet or dilutor to be ... kit is then returned to Streck for analysis ...
... Cyto-Chex BCT is a vacuum tube ... whole blood samples for immunophenotyping by flow ... maintains the integrity of the white blood ... up to seven days. Patient samples collected ...
Medicine Products: