Navigation Links
New accurate epigenetic test could eliminate unnecessary repeat biopsies for prostate cancer
Date:7/21/2014

New York, NY -- More than one million prostate biopsies are performed each year in the U.S. alone, including many repeat biopsies for fear of cancer missed. Therefore there is a need to develop diagnostic tests that will help avoid unnecessary repeat biopsies. Two independent trials have now validated the performance of an epigenetic test that could provide physicians with a better tool to help eliminate unnecessary repeat prostate biopsies, report investigators in The Journal of Urology.

In the previously reported independent MATLOC (Methylation Analysis To Locate Occult Cancer) trial, a multiplex epigenetic assay (ConfirmMDx for Prostate Cancer) profiling the APC, GSTP1 and RASSF1 genes demonstrated a negative predictive value of 90%. GSTP1 methylation is a specific biomarker for (prostate) cancer and this gene is methylated in up to 90% of prostate cancer cases. Additionally, APC and RASSF1 are important field effect markers and increase the diagnostic sensitivity of the assay.

A second multicenter study, DOCUMENT (Detection Of Cancer Using Methylated Events in Negative Tissue), has validated the performance of the epigenetic assay used in the MATLOC trial as an independent predictor of prostate cancer risk to guide decision making for repeat biopsy. In the DOCUMENT study patients with a negative biopsy were evaluated to identify those at low risk for harboring cancer missed, through biopsy sampling error, who could forego an unnecessary repeat biopsy. The validation study resulted in a negative predictive value of 88%.

"This epigenetic assay is a significant, independent predictor and has been shown to be the most valuable diagnostic aid of all evaluated risk factors in two independent trials," comments Alan W. Partin, MD, PhD, of the James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland. "Negative findings of this assay could be used to reduce concern over unsampled cancer and effectively avoid unnecessary repeat biopsies."

A total of 350 patients were enrolled in the DOCUMENT trial from five geographically dispersed medical centers: Cleveland Clinic, Eastern Virginia Medical School, Lahey Hospital & Medical Center, Johns Hopkins University, and University of California Los Angeles. Patients were grouped into those with two consecutive negative biopsies (controls) and those with a negative biopsy followed by a positive biopsy within 24 months. The initial archived, negative for cancer, prostate biopsy core tissue samples were evaluated. All of the men underwent a repeat biopsy on average one year after the initial biopsy.

Only biopsies with a minimum of eight cores per biopsy, collected no earlier than 2007, were included in the study, while initial biopsies with atypical cells suspicious for cancer, i.e. atypical small acinar proliferation by the sites' pathologists, were excluded, since this would have triggered a repeat biopsy based upon histopathology alone.

After correcting for age, prostate specific antigen (PSA), digital rectal exam, histopathological characteristics of the first biopsy, and race, this epigenetic test proved to be the most significant, independent, and strongest predictor of patient outcome with an odds ratio of 2.69 as well as the most valuable diagnostic aid of all evaluated risk factors. The slightly decreased sensitivity of the DOCUMENT trial compared to the MATLOC trial is most likely associated with a higher PSA screening prevalence in the DOCUMENT cohort.


'/>"/>
Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. Unique approach needed to accurately assess health of young adult cancer survivors
2. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
3. 2 new vitamin D blood tests are often highly inaccurate, researchers say
4. All-they-can-eat diet for lab mice and rats may foster inaccurate test results
5. Heterogeneous ER+ breast cancer models allow more accurate drug testing
6. Advanced CT scans accurately assess coronary blockages
7. Most Accurate Climate Models Point to More Global Warming
8. Structure of enzyme unravelled providing basis for more accurate design of chemotherapeutic drugs
9. Electronic visits offer accurate diagnoses, may lead to overprescribing of antibiotics
10. Websites Touting Designer Vagina Surgeries Often Inaccurate, Study Finds
11. PET imaging used to more accurately manage treatment, predict survival for patients with gliomas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/25/2017)... ... , ... Your World Insurance Services, a long-time Redlands insurance and financial services ... of owner Stacy Boyle to give back to the many charitable organizations that help ... high school,” said Ms. Boyle. “My father passed away without life insurance, and my ...
(Date:9/25/2017)... (PRWEB) , ... September 25, 2017 , ... ... to Arizona State University student Ashlea Grabau. The $1000 student scholarship is awarded ... 2017 scholarship was awarded to Ashlea Grabau who is a medical student at ...
(Date:9/25/2017)... ... 25, 2017 , ... Sensogram Technologies Inc. today launched an ... watch. VitalBand provides elite level fall detection, automatically calls any number you ... quickly. Plus, it’s a fully functioning smart watch and activity tracker. , ...
(Date:9/25/2017)... ... September 25, 2017 , ... The Coleman Institute, a ... an affiliate in Minneapolis-St. Paul, MN, Dr. Adam Locketz. Dr. Locketz will be ... aftercare planning through his Timewise Medical practice in the twin cities. , ...
(Date:9/25/2017)... ... ... The Renal Support Network (RSN) is proud to announce the launch of ... focused on RSN’s mission to empower people who have kidney disease to become knowledgeable ... Our unique website is loaded with hundreds of exclusive personal stories. These posts are ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , ... supply chains, has published the first annual edition of its Global CSR ... than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed ... ... & Performance Index ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., ... Solutions (VLMS), is pleased to announce the appointment ... member of its Board of Directors and Chairman ... VLMS enables life science companies to manage their ... use of paper in this process. Furthermore, ValGenesis ...
(Date:9/9/2017)... -- Dealmed Medical Supplies, New York City,s ... drugs, vaccines, and specialty medical products and services, announced ... acquire Vantage Medical Supplies, a major distributor of medical ... York . ... practices, will operate under the Dealmed name as of ...
Breaking Medicine Technology: