Navigation Links
New York Stem Cell Foundation scientists featured for new model of Alzheimer's disease
Date:7/16/2012

NEW YORK, NY (July 16, 2012) A team of scientists at The New York Stem Cell Foundation (NYSCF) Laboratory led by Scott Noggle, PhD, NYSCFCharles Evans Senior Research Fellow for Alzheimer's Disease, has developed the first cell-based model of Alzheimer's disease (AD) by reprogramming skin cells of Alzheimer's patients to become brain cells that are affected in Alzheimer's. This will allow researchers to work directly on living brain cells suffering from Alzheimer's, which until now had not been possible. Andrew Sproul, PhD, a postdoctoral associate in Dr. Noggle's laboratory, will present this work on Thursday, July 19 at the Alzheimer's Association International Conference (AAIC) held in Vancouver.

Dr. Noggle and his team reprogrammed skin cell samples taken from twelve patients diagnosed with early-onset Alzheimer's and from healthy, genetically related individuals into induced pluripotent stem (iPS) cells, which can differentiate into any cell type. The team of scientists used these iPS cells to create cholinergic basal forebrain neurons, the brain cells that are affected in Alzheimer's. These cells recapitulate the features and cellular-level functions of patients suffering from Alzheimer's, a devastating disease that affects millions of people globally but for which there is currently no effective treatment.

NYSCF has pioneered the creation of disease models based on the derivation of human cells. Four years ago, a NYSCF-funded team created a cell-based model for ALS, or motor neuron disease, the first patient-specific stem cells created for any disease. The cell-based model for Alzheimer's builds on this earlier work.

"Patient derived AD cells will prove invaluable for future research advances, as they already have with patient-derived ALS cells," said NYSCF CEO Susan Solomon. "They will be a critical tool in the drug discovery process, as potential drugs could be tested directly on these cells. Although research on animals ha
'/>"/>

Contact: David McKeon
dmckeon@nyscf.org
212-365-7440
New York Stem Cell Foundation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Kessler Foundations A.M. Barrett appointed to National Quality Forum Steering Committee
2. The Ben & Catherine Ivy Foundation contributes $10 million to TGen for brain cancer research
3. Damon Runyon Cancer Research Foundation grants fellowship awards to 21 top young scientists
4. Lauren Sciences LLCs research team at Ben-Gurion University awarded Campbell Foundation grant to develop a V-Smart therapeutic for neuro-HIV
5. Taxman Foundation pledges $2.5 million to boost training of digestive disease experts
6. IQware Solutions is Pleased to Announce that IQware MTM has Been Selected by the Tennessee Pharmacists Research and Education Foundation (TPREF)
7. Actos Bladder Cancer Lawsuit Filed in Louisiana Alleging Woman Used Diabetes Medication and Contracted Bladder Cancer, Consumer Justice Foundation Reports
8. Damon Runyon Cancer Research Foundation awards $3.3 million to 8 top young clinical investigators
9. Kessler Foundation scientists present cognitive research findings at MS dual symposium
10. Biomedical researchers receive Hartwell Foundation awards
11. Kessler Foundation researchers present at first International Congress on Cognition in MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... BC (PRWEB) July 13, 2014 Victorian ... excitement by promoting the rental of bikes for its ... historic downtown Victorian Hotel to tour the area using ... plus tax. Bicycle enthusiasts love to call Vancouver home, ... options for cycle travel and picturesque journeys through the ...
(Date:7/13/2014)... 2014 The report “Micronutrient Market ... Form (Chelated & Non Chelated), Application Mode (Soil, ... Trends and Forecast to 2018” defines and segments ... and forecasting of the global value and volume ... and restraining factors for the global agriculture micronutrients ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 According ... Processing and Computing Market by Component (processor, GPU, ... Automotive, MDA, Medical), and Geography - Forecast and ... Heterogeneous Mobile Processing & Computing Market is expected ... a CAGR of 20.75% from 2014 to 2020. ...
(Date:7/13/2014)... Serena Gordon HealthDay Reporter ... type of sensor for people with diabetes is being developed ... of blood, researchers report. Scientists at Brown University in ... artificial saliva. It uses light, metal and a special enzyme ... knows that diabetics have to prick their fingers to draw ...
(Date:7/13/2014)... York, New York (PRWEB) July 13, 2014 ... lawsuits ( http://www.transvaginalmeshlawsuithelp.com/ ) filed against Johnson ... litigation’s second bellwether trial, which is expected to get ... Order issued in the U.S. District Court, Southern District ... Conference will be held on August 7, 2014 at ...
Breaking Medicine News(10 mins):Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 2Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4
... , This release is available in German ... Foundation) establishes four new Research Units. This decision has just ... meeting in Bonn in April. In Research Units, outstanding researchers ... locations and across disciplines. The DFG funding thereby secures the ...
... , WEDNESDAY, April 20 (HealthDay News) -- Excessive sleeping, ... a greatly increased risk for behavioral problems later in ... describe as "regulatory problems," were the focus of an ... Data came from 16,848 children, including 1,935 with regulatory ...
... at the Mailman School of Public Health report evidence of ... deficits in IQ and working memory at age seven. ... prenatal chlorpyrifos exposure on cognitive development at the time of ... Perspectives . Until banned for indoor residential use ...
... , WEDNESDAY, April 20 (HealthDay News) -- ... family instability has no effect, a new study suggests. ... children and their families when the children were 9 ... provided insight into family poverty, family transitions, family demographics ...
... WEDNESDAY, April 20 (HealthDay News) -- Researchers have developed a ... pregnant women will deliver their babies prematurely. The ... foolproof: a study found that it misses some premature births ... an important tool for an obstetrician who currently has no ...
... , WEDNESDAY, April 20 (HealthDay News) -- Inhaled ... patients with chronic obstructive pulmonary disease, or COPD, who ... U.S. researchers examined the medical records of 15,768 ... VA hospitals for pneumonia between 2002 and 2007. Of ...
Cached Medicine News:Health News:DFG establishes 4 new research units 2Health News:DFG establishes 4 new research units 3Health News:Babies' Persistent Fussiness Could Mean Behavioral Woes Ahead 2Health News:Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7 2Health News:Poverty Can Hinder a Child's Cognitive Development, Study Says 2Health News:Experimental Test May Warn of Premature Births 2Health News:Inhaled Meds May Save COPD/Pneumonia Patients' Lives 2
(Date:7/11/2014)... LOUIS , July 11, 2014 /PRNewswire/ ... device company, announced today the positive, cost-effective ... its innovative SPiNPerc™ procedure. The SPiNPerc endobronchial ... of a percutaneous approach to biopsy when ... Hospitals, patients and physicians experience positive financial ...
(Date:7/10/2014)... 2014  The U.S. Department of Health and Human ... Hospitals (UH) Case Medical Center Seidman Cancer Center totaling ... at improving care for patients with complex cancer. ... test a unique model developed at UH to enhance ... comorbidities, or demonstrated need for high health care utilization.  ...
(Date:7/10/2014)... 2014  BC Technical, the largest nationwide, non-OEM provider ... Inc., a leading provider of Siemens Nuclear Medicine and ... naming BC Technical as the authorized provider of service ... and BC Technical announced today that the two companies ... as the service and systems provider for MiE,s camera ...
Breaking Medicine Technology:Veran Medical Publishes Lung Cancer Patient Management Study 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... 2011 ChromaDex Corporation (OTCBB: CDXC), an innovative ... and ingredients to the dietary supplement, food & ... results for the second quarter of 2011. On ... U.S. Generally Accepted Accounting Principles (U.S. GAAP), ChromaDex ...
... NEW YORK, Aug. 11, 2011 Citeline, an Informa ... pharmaceutical clinical trials recently reviewed the findings from the ... July 16-21, 2011, noting that while pharma continues to ... ahead in terms of biomarkers and early warning for ...
Cached Medicine Technology:ChromaDex Announces Financial Results for Second Quarter 2011 2ChromaDex Announces Financial Results for Second Quarter 2011 3ChromaDex Announces Financial Results for Second Quarter 2011 4Global Standardization for Alzheimer's Biomarkers Moves a Major Step Closer to Reality 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: