Navigation Links
New Weapons in Fight Against TB?

Parkinsons drugs may thwart treatment-resistant strain, study finds

FRIDAY, July 3 (HealthDay News) -- Extreme drug-resistant tuberculosis might someday meet its match in two drugs now used to treat Parkinson's disease, suggests a new study.

Researchers, led by a team from the University of California, San Diego, report in the July 3 issue of PLoS Computational Biology that commercially available entacapone and tolcapone have the potential to treat the difficult-to-kill strain of TB.

The discovery was made after a computational analysis that found the chemical structure of the two Parkinson's drugs might work to thwart the TB enzyme InhA, which previous research had determined to be a prime target in treating the disease. A subsequent lab experiment found that the active ingredient in the two drugs inhibited the M. tuberculosis bacterium without being deadly to its host cells.

"We have computational and experimental data to support this [drug] repositioning," principle investigator Philip E. Bourne, a professor of pharmacology at the university's Skaggs School of Pharmacy and Pharmaceutical Sciences, said in a university news release. "Here we have drugs that are known to be safe and with suitable binding properties which can be further optimized to treat a completely different condition."

About 2 million people each year die from extreme drug-resistant tuberculosis, which poses a worldwide threat.

The study's lead author, graduate student Sarah L. Kinnings, said the lab experiment was just a step in the long process of possibly creating a new TB treatment.

"Given the continuing emergence of M. tuberculosis strains that are resistant to all existing, affordable drug treatments, the development of novel, effective and inexpensive drugs is an urgent priority," she said in the news release.

More information

The U.S. Centers for Disease Control and Prevention has more about tuberculosis.

-- Kevin McKeever

SOURCE: University of California, San Diego, news release, July 2, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blast overpressure is generated from the firing of weapons and may cause brain injury
2. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
3. Research May Yield New Weapons Against Sepsis
4. Calling All Runners: Join the Fight Against Cancer
5. Fighting Multiple Sclerosis One Shirt at a Time
6. Roche Diabetes Care Announces Unique Coaching Program for Diabetes Educators as Part of Long-Term Commitment to Fight the Disease
7. Delawares Partnership to Fight Chronic Disease Breakfast Highlights Promising Practices in Managing Chronic Disease Provides Solutions for Reduced Spending and Improved Patient Health
8. European researchers look for new ways to fight multi-drug-resistant bacterial infections
9. Respiratory Rally a Promising Practice in the Fight Against Chronic Disease
10. New Cancer Drug Fights Tumors in Those With BRCA Mutations
11. HMS Urges Healthcare Reform Measures to Manage Costs, Target Resources, Fight Fraud
Post Your Comments:
Related Image:
New Weapons in Fight Against TB?
(Date:11/30/2015)... ... November 30, 2015 , ... The Progressive Dental ... on January 29 and 30, 2016. The course welcomes dental professionals and members ... to learn how to better succeed in the modern dental marketplace. The course ...
(Date:11/30/2015)... ... , ... A record crowd gathered at the Pennsylvania Biotech Center of Bucks ... Blumberg Institute. , The institute, which is the research arm of the Hepatitis B ... the conference, which focused on ways companies can work to reduce the cost and ...
(Date:11/30/2015)... ... 30, 2015 , ... HemoTreat™ has announced that the company ... to its website. , “Our goal is simple:” says Michael Blasco, HemoTreat’s Chief ... comparison chart and ingredient list allows our customers to quickly see why, and ...
(Date:11/30/2015)... ... November 30, 2015 , ... ChiliPad ... looking to maximize recovery through quality sleep. Tim DiFrancesco, training coach for the ... better night’s sleep. ChiliPad precisely regulates the surface temperature of each side of ...
(Date:11/30/2015)... ... November 30, 2015 , ... Advocare ... centered orthopedic care. Led by John Vitolo, M.D., the center offers their ... the team at Advocare Orthopedic & Sports Medicine is ready to help their ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015   VolitionRx Limited (NYSE MKT: VNRX), ... for a broad range of cancer types and other conditions, ... Conference, which will be held December 1 - 3 in in ... will be David Kratochvil , Chief Financial Officer and ... Relations. ® blood-based tests for colorectal cancer ...
(Date:11/30/2015)... LONDON , November 30, 2015 Mexico ... Healthcare and Life Sciences Report 2015 . --> Pharmaboardroom ... 2015 . Latin America , a country ... , a country of over 122 million people. --> ... in healthcare, pharmaceuticals, or life sciences insights into the second largest ...
(Date:11/30/2015)... SHELTON, Connecticut , November 30, 2015 ... Kentucky Breast Care has entered into a ... women,s healthcare practice. This will allow Kentucky Breast Care ... and offer exceptional care for their patients. ... Kentucky Breast Care has entered into a ...
Breaking Medicine Technology: