Navigation Links
New Weapons in Fight Against TB?

Parkinsons drugs may thwart treatment-resistant strain, study finds

FRIDAY, July 3 (HealthDay News) -- Extreme drug-resistant tuberculosis might someday meet its match in two drugs now used to treat Parkinson's disease, suggests a new study.

Researchers, led by a team from the University of California, San Diego, report in the July 3 issue of PLoS Computational Biology that commercially available entacapone and tolcapone have the potential to treat the difficult-to-kill strain of TB.

The discovery was made after a computational analysis that found the chemical structure of the two Parkinson's drugs might work to thwart the TB enzyme InhA, which previous research had determined to be a prime target in treating the disease. A subsequent lab experiment found that the active ingredient in the two drugs inhibited the M. tuberculosis bacterium without being deadly to its host cells.

"We have computational and experimental data to support this [drug] repositioning," principle investigator Philip E. Bourne, a professor of pharmacology at the university's Skaggs School of Pharmacy and Pharmaceutical Sciences, said in a university news release. "Here we have drugs that are known to be safe and with suitable binding properties which can be further optimized to treat a completely different condition."

About 2 million people each year die from extreme drug-resistant tuberculosis, which poses a worldwide threat.

The study's lead author, graduate student Sarah L. Kinnings, said the lab experiment was just a step in the long process of possibly creating a new TB treatment.

"Given the continuing emergence of M. tuberculosis strains that are resistant to all existing, affordable drug treatments, the development of novel, effective and inexpensive drugs is an urgent priority," she said in the news release.

More information

The U.S. Centers for Disease Control and Prevention has more about tuberculosis.

-- Kevin McKeever

SOURCE: University of California, San Diego, news release, July 2, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blast overpressure is generated from the firing of weapons and may cause brain injury
2. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
3. Research May Yield New Weapons Against Sepsis
4. Calling All Runners: Join the Fight Against Cancer
5. Fighting Multiple Sclerosis One Shirt at a Time
6. Roche Diabetes Care Announces Unique Coaching Program for Diabetes Educators as Part of Long-Term Commitment to Fight the Disease
7. Delawares Partnership to Fight Chronic Disease Breakfast Highlights Promising Practices in Managing Chronic Disease Provides Solutions for Reduced Spending and Improved Patient Health
8. European researchers look for new ways to fight multi-drug-resistant bacterial infections
9. Respiratory Rally a Promising Practice in the Fight Against Chronic Disease
10. New Cancer Drug Fights Tumors in Those With BRCA Mutations
11. HMS Urges Healthcare Reform Measures to Manage Costs, Target Resources, Fight Fraud
Post Your Comments:
Related Image:
New Weapons in Fight Against TB?
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC ... by obtaining investment capital for emerging technology companies. SCP has delivered investment ... resulted in more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
(Date:6/24/2016)... Gilbert, Arizona (PRWEB) , ... June 24, 2016 ... ... Gilbert-based practice, is supporting the upcoming 2016 Miss Arizona pageant as its official ... primarily serves Scottsdale, Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment ... Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... General Manager of Astellas Farma Colombia ... ...
(Date:6/23/2016)... PRINCETON, N.J. , June 23, 2016  Guerbet ... of Premier Inc.,s Supplier Horizon Award . ... this year, Guerbet was recognized for its support of ... value creation through clinical excellence, and commitment to lower ... delighted to receive this recognition of our outstanding customer ...
(Date:6/23/2016)... June 23, 2016 Research and ... Procedure Volumes: Global Analysis (United States, China, Japan, Brazil, ... report to their offering. ... for healthcare business planners, provides surgical procedure volume data ... trends with an in-depth analysis of growth drivers and ...
Breaking Medicine Technology: