Navigation Links
New Way Found to Diagnose Endometriosis
Date:8/20/2009

Less invasive test focuses on nerve fibers, researchers say,,

THURSDAY, Aug. 20 (HealthDay News) -- A new test for endometriosis, the painful gynecologic condition that can impair fertility, requires no surgery and is extremely accurate, two studies show.

However, other experts said the accuracy of the new approach, which spots the telltale presence of nerve fibers, needs to be replicated, which the researchers also acknowledged.

Until now, a diagnosis of endometriosis -- in which the tissue that lines the uterus, called the endometrium, grows outside the uterus -- was made by inspection of the pelvis via laparoscopy, a procedure that requires anesthesia.

"Laparoscopy is invasive," said Dr. Thomas D'Hooghe, a professor of medicine at Leuven University in Belgium and co-author of one of the studies. "Our test is semi-invasive -- office-based, done by a gynecologist, limited discomfort."

Both studies were published online Aug. 19 in the journal Human Reproduction.

The condition affects about 5.5 million women and girls in the United States and Canada, according to the Endometriosis Association. The tissue that grows outside the uterus develops into growths or lesions that respond to the menstrual cycle in the way the uterine lining does, building and breaking down each month.

But the blood and tissue shed from these growths can't leave the body as menstrual blood does, so internal bleeding, pain, inflammation and infertility can result.

The cause is unknown, and the severity of the condition and the level of pain and other symptoms don't always correlate, experts said.

To do the new test, physicians take a small sample of the lining of the uterus by inserting the device used for taking an endometrial biopsy through the vagina. Then they test the sample for the presence of nerve fibers.

This enables them to determine whether or not endometriosis is present with nearly 100 percent accuracy, as D'Hooghe and his colleagues report. For the study, they compared samples of the endometrium from 40 women who had confirmed disease with samples from 20 women without the condition. The density of the small nerve fibers was about 14 times higher in the samples from patients with endometriosis than in those with a normal pelvis.

In a second study, researchers from Australia and Jordan took endometrial samples from 99 women presenting with pelvic pain or infertility, or both, who had undergone laparoscopy. They compared the laparoscopy and biopsy results. In 64 women who had endometriosis confirmed by laparoscopy, all but one tested positive for the presence of nerve fibers in the biopsy.

In the 35 women who did not have endometriosis diagnosed in the laparoscopy, no nerve fibers were found in 29 of the biopsies.

The new research builds on previous work, said study co-author Dr. Moamar Al-Jefout, an assistant professor of reproductive medicine at Mu'tah University in Karak, Jordan. That research, led by Dr. Ian Fraser in Australia, found that "women with endometriosis have nerve fibers in the functional layer of the endometrial, while women without endometriosis have no nerve fibers," Al-Jefout said.

Other experts lauded the results, but also had some caveats. "This test is [still] semi-invasive," said Mary Lou Ballweg, a spokeswoman for the Endometriosis Association. The biopsy procedure can be painful, she added.

Another expert, Dr. Pamela Stratton, chief of the gynecology consult service for the National Institutes of Health, who does endometriosis research, called the new studies "provocative."

"This is a very novel way of thinking about this," she said. "Everyone has been focusing on the lesions themselves."

Still, she said, more research is needed. "Its clinical usefulness isn't really known yet," she said of the new approach.

"Let's say the jury is out," agreed Dr. Karen J. Berkley, professor emerita of neuroscience at Florida State University in Tallahassee. "The underlying idea [linking nerve fibers and endometriosis] is not yet understood."

While the technique can be done in the office, it's not trivial, she said. "An endometrial biopsy can be a big deal for someone with a lot of pain," she said.

Even so, news of simpler tests "is very exciting," said Dr. David Healy, of Monash University in Melbourne, Australia, and president-elect of the International Federation of Fertility Societies. In a statement, he said: "If other doctors can confirm this test, this might become the standard way of diagnosing endometriosis. This would mean that the condition could be identified earlier, which could give real benefits for the infertile woman."

More information

To learn more about endometriosis, visit the Endometriosis Association.



SOURCES: David Healy, M.D., Ph.D., president-elect, International Federation of Fertility Societies; Pamela Stratton, M.D., chief, gynecology consult service, National Institutes of Health, Bethesda, Md.; Karen J. Berkley, Ph.D., professor emerita, neuroscience, Florida State University, Tallahassee; Moamar Al-Jefout, M.D., Ph.D., assistant professor, reproductive medicine, Mu'tah University, Karak, Jordan; Thomas M. D'Hooghe, M.D., Ph.D., professor, medicine, Leuven Unviersity, Leuven, Belgium; Mary Lou Ballweg, spokeswoman, Endometriosis Association; Aug. 19, 2009, Human Reproduction, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Film Event to Support United Cerebral Palsy (UCP) of Central Arizona and the Phoenix Film Foundation
2. New robot-assisted surgical method found successful for treatment of thyroid cancer
3. COSHAR Foundation Enhances National Childhood Immunization Awareness Campaign
4. rL Solutions to Become the Founding Corporate Alliance Sponsor of the Society for Healthcare Consumer Advocacy
5. Laurence Barsh, DMD, Founder of Snoring Isn't Sexy, LLC Emphasizes Need to Evaluate and Treat Sleep Patients
6. The Blue Foundation for a Healthy Florida Receives Grant to Address National/Regional Nursing Shortages
7. Trust for Americas Health Praises Major Foundations for Supporting Prevention as a Central Part of Health Reform
8. Leading Health Foundations Say Prevention is Vital to Health Systems Reform
9. Sebastian Ferrero Foundation to Host 2nd Annual Fundraiser, Noche de Gala
10. First compound that specifically kills cancer stem cells found
11. Bill & Melinda Gates Foundation Appoints Joe Cerrell to Lead New European Office
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Way Found to Diagnose Endometriosis 
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
(Date:6/24/2016)... ... 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The ... members that have been wounded in battle and their families. Venture Construction Group is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... 23, 2016 , , , ... 7, 2016 , , , , LOCATION: , , , ... , , , EXPERT PANELISTS:  , , , Frost & Sullivan,s ... Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program ... global pharmaceutical industry is witnessing an exceptional era. Several new demand ...
Breaking Medicine Technology: