Navigation Links
New Vaccine May Help Type 1 Diabetics in Future
Date:10/8/2008

Early study finds it appears to sustain insulin production in the newly diagnosed.

WEDNESDAY, Oct. 8 (HealthDay News) -- Swedish researchers have developed a vaccine that may change the way the immune system responds in people who are newly diagnosed with type 1 diabetes.

"By a very simple vaccination, without adverse events, it seems possible to save [a person's] own insulin secretion, which may be extremely important for diabetic children and adolescents," said the study's lead author, Dr. Johnny Ludvigsson, a professor of pediatrics and head physician at Linkoping University Hospital.

However, the results of this preliminary study didn't change the clinical course of the disease for the study participants. Insulin requirements of children involved in the study were similar whether the children were treated with the new vaccine or received a placebo.

Results of the study were released Wednesday online by the New England Journal of Medicine, and will be published in its Oct. 30 issue.

Type 1 diabetes is believed to be an autoimmune disease in which the body's immune system mistakenly attacks itself. In type 1 diabetes, "insulin-producing cells are killed by their own immune system in a 'civil war,' " said Ludvigsson. This civil war leads to a lack of insulin in the body, and insulin is a key hormone that allows the body to metabolize carbohydrates and sugar from foods. Without replacement insulin, people with type 1 diabetes would die. Even with treatment, there are numerous complications that can occur, including damage to the kidneys, eyes, heart and nerves.

Past research on interrupting an immune system gone awry has focused on drugs that suppress the immune system, like those used for people receiving transplants or being treated for cancer. Although researchers did have some success in slowing or stopping early-onset diabetes, that success came at a cost.

"Many drugs caused severe toxic side effects," said Dr. Denise Faustman, director of immunobiology at Massachusetts General Hospital in Boston, and the author of an accompanying editorial in the journal. "With a big immune suppressant, you can change the amount of insulin kids take, sometimes you can even make them insulin-free for awhile, but you may cause kidney damage. The ratio of toxicity versus benefit wasn't there."

The new vaccine treatment under study focuses on the immune response, rather than trying to blunt the entire immune system. It's made of a protein called GAD that's normally found in the brain and in the insulin-producing islet cells of the pancreas. In people with diabetes, it's as if they're allergic to GAD, Ludvigsson explained.

The hope is that the vaccine he and his team developed -- which was administered the first day of the study and then again at day 30 -- will work in a similar manner to allergy immunotherapy and help the body learn to tolerate GAD again.

The study included 70 children between the ages of 10 and 18 who had been diagnosed with type 1 diabetes no more than 18 months before the start of the study. The children were randomly split into two groups -- one received treatment, the other a placebo.

At the end of the study, insulin requirements didn't change. But, in children who were more recently diagnosed, there was evidence that the treated group retained more activity in their pancreas, Ludvigsson said.

That's important because the more insulin-producing function you retain, "the short-term risks are less, as are the risk of long-term complications," said Dr. Richard Insel, executive vice president of research for the Juvenile Diabetes Research Foundation.

"What you're seeing is, the field is trying to move away from broad-based immunosuppression to targeting one specific immune response, and this is an early attempt to develop a much more focused approach to modulate immune function in new-onset diabetes," Insel said.

The good news is that the vaccine seemed safe and didn't cause any troubling side effects, according to Faustman. "GAD looks pretty benign here -- two vaccinations given four weeks apart. There's something positive happening, though the therapeutic benefit is small. But, there was a measurable and significant benefit."

Ludvigsson said the researchers have begun new trials, including children who've had diabetes for a much shorter time because those were the ones who responded most in this study. Additionally, they'll be working on a clinical trial to see if this vaccination could be used to prevent type 1 diabetes from occurring in children who have a high risk of the disease.

More information

Learn more about type 1 diabetes from the U.S. National Library of Medicine.



SOURCES: Johnny Ludvigsson, M.D., Ph.D., professor of pediatrics, and head physician, Linkoping University Hospital, Sweden; Denise L. Faustman, M.D., Ph.D., director, immunobiology, Massachusetts General Hospital, and associate professor of medicine, Harvard Medical School, Boston; Richard Insel, M.D., executive vice president, Juvenile Diabetes Research Foundation; Oct. 30, 2008, New England Journal of Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
3. Vaccine Stops Alzheimers Brain Tangles
4. Human Papilloma Virus vaccines may decrease chances of oral cancer
5. U.S. Teens Fall Short on Vaccine Coverage
6. Nasal Anthrax Vaccine Proves Effective in Animal Study
7. Hot ice, measuring depression, perfect invisibility and flu vaccine incentives
8. Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine
9. Iomai Patch-Based Vaccine Cut Rate of Travelers Diarrhea by 75 Percent in Phase 2 Field Study
10. FDA approves expanded label for FluMist (influenza virus vaccine live, intranasal) to include childr
11. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
Breaking Medicine Technology: