Navigation Links
New UTHealth trial aimed at helping pregnant women stop smoking
Date:5/4/2011

HOUSTON (May 4, 2011) A clinical trial to test the safety and efficacy of a medication that could help pregnant women stop smoking has begun enrollment at The University of Texas Health Science Center at Houston (UTHealth).

The study targets pregnant women in their second and third trimesters when smoking can be quite harmful to the fetus, said Angela Stotts, Ph.D., associate professor in the Department of Family and Community Medicine at the UTHealth Medical School.

"Pregnant women receive counseling or self-help materials but they may need something more powerful to stop smoking. Nicotine is one of the hardest substances to quit due to its action in the brain," Stotts said.

The medication, bupropion, is known under the brand name Zyban for smoking cessation and as the antidepressant Wellbutrin in a stronger formula.

"In nonpregnant smokers, bupropion has been shown to almost double the success rate of smoking cessation and is a relatively safe medication," Stotts said. "Some obstetricians already prescribe it during pregnancy for depression."

Pregnant women who smoke are twice as likely to suffer premature rupture of membranes, placental abruption and placenta previa, according to the Centers for Disease Control and Prevention. They also have a 30 percent higher chance of delivering prematurely and their infants are up to three times more likely to die from sudden infant death syndrome. Infants born to smoking mothers also have a higher rate of low birth weight, increasing their risk for illness or death. Some studies have also linked developmental problems such as attention disorders to mothers who smoked during pregnancy.

According to a 2004 CDC report, on average, 13 percent of women continued to smoke during their pregnancy. This varies dramatically by region, however, with the South having some of the highest rates, Stotts said.

"Smoking is an addiction and women who continue to smoke during pregnancy often say they want to quit for the benefit of their baby, but just can't overcome the need. We currently don't have many pharmacological options to assist them. Therefore, I think this study is extremely important and will impact our patients in a meaningful way," said Sean Blackwell, M.D., co-investigator and associate professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at UTHealth. Blackwell is also the director of UTHealth's Larry C. Gilstrap Center for Perinatal and Women's Health Research.

A 2001 brain activation study published in the Archive of General Psychiatry concluded that bupropion appears to reduce the cravings associated with smoking. "It's an atypical antidepressant and the mechanism is not well known but we believe it works on several systems. We think it's mediated through the dopaminergic and noradrenergic systems," Stotts said. "It might act as an antagonist, blocking the effects of the nicotine, so people might not experience the same pleasant reinforcing properties of nicotine."


'/>"/>

Contact: Deborah Mann Lake
deborah.m.lake@uth.tmc.edu
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related medicine news :

1. UTHealth study: Stem cells may provide treatment for brain injuries
2. Helicobacter pylori infection linked to decreased iron levels in otherwise healthy children, according to research at UTHealth
3. UTHealth study suggests private insurers control health care spending better than Medicare
4. UTHealth receives $11 million NIDA grant
5. UTHealth researchers awarded $15 million for teen pregnancy prevention
6. UTHealth researcher receives grant for Alzheimers study
7. Sugary sports drinks mistakenly associated with being healthy, say UTHealth researchers
8. UTHealth School of Nursing to host conference on aging and abuse
9. UTHealth receives $15 million for health information technology research
10. UTHealth to serve as Health Information Technology Regional Extension Center
11. Data evaluates rehospitalization and cost burden of AFib/atrial flutter
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New UTHealth trial aimed at helping pregnant women stop smoking
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... extensive sequencing and genomics experience, as Vice President of North American Capital Sales at ... responsible for leading the sales team in the commercialization of the HTG EdgeSeq system ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: