Navigation Links
New UTHealth trial aimed at helping pregnant women stop smoking
Date:5/4/2011

HOUSTON (May 4, 2011) A clinical trial to test the safety and efficacy of a medication that could help pregnant women stop smoking has begun enrollment at The University of Texas Health Science Center at Houston (UTHealth).

The study targets pregnant women in their second and third trimesters when smoking can be quite harmful to the fetus, said Angela Stotts, Ph.D., associate professor in the Department of Family and Community Medicine at the UTHealth Medical School.

"Pregnant women receive counseling or self-help materials but they may need something more powerful to stop smoking. Nicotine is one of the hardest substances to quit due to its action in the brain," Stotts said.

The medication, bupropion, is known under the brand name Zyban for smoking cessation and as the antidepressant Wellbutrin in a stronger formula.

"In nonpregnant smokers, bupropion has been shown to almost double the success rate of smoking cessation and is a relatively safe medication," Stotts said. "Some obstetricians already prescribe it during pregnancy for depression."

Pregnant women who smoke are twice as likely to suffer premature rupture of membranes, placental abruption and placenta previa, according to the Centers for Disease Control and Prevention. They also have a 30 percent higher chance of delivering prematurely and their infants are up to three times more likely to die from sudden infant death syndrome. Infants born to smoking mothers also have a higher rate of low birth weight, increasing their risk for illness or death. Some studies have also linked developmental problems such as attention disorders to mothers who smoked during pregnancy.

According to a 2004 CDC report, on average, 13 percent of women continued to smoke during their pregnancy. This varies dramatically by region, however, with the South having some of the highest rates, Stotts said.

"Smoking is an addiction and women who continue to smoke during pregnancy often say they want to quit for the benefit of their baby, but just can't overcome the need. We currently don't have many pharmacological options to assist them. Therefore, I think this study is extremely important and will impact our patients in a meaningful way," said Sean Blackwell, M.D., co-investigator and associate professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at UTHealth. Blackwell is also the director of UTHealth's Larry C. Gilstrap Center for Perinatal and Women's Health Research.

A 2001 brain activation study published in the Archive of General Psychiatry concluded that bupropion appears to reduce the cravings associated with smoking. "It's an atypical antidepressant and the mechanism is not well known but we believe it works on several systems. We think it's mediated through the dopaminergic and noradrenergic systems," Stotts said. "It might act as an antagonist, blocking the effects of the nicotine, so people might not experience the same pleasant reinforcing properties of nicotine."


'/>"/>

Contact: Deborah Mann Lake
deborah.m.lake@uth.tmc.edu
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related medicine news :

1. UTHealth study: Stem cells may provide treatment for brain injuries
2. Helicobacter pylori infection linked to decreased iron levels in otherwise healthy children, according to research at UTHealth
3. UTHealth study suggests private insurers control health care spending better than Medicare
4. UTHealth receives $11 million NIDA grant
5. UTHealth researchers awarded $15 million for teen pregnancy prevention
6. UTHealth researcher receives grant for Alzheimers study
7. Sugary sports drinks mistakenly associated with being healthy, say UTHealth researchers
8. UTHealth School of Nursing to host conference on aging and abuse
9. UTHealth receives $15 million for health information technology research
10. UTHealth to serve as Health Information Technology Regional Extension Center
11. Data evaluates rehospitalization and cost burden of AFib/atrial flutter
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New UTHealth trial aimed at helping pregnant women stop smoking
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... AccentCare, a leader in post-acute health care, have expanded their existing home health ... Home Health. , AccentCare has been operating a joint venture home health company ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
(Date:10/12/2017)... Mich. (PRWEB) , ... October 12, 2017 , ... ... has been named one of Michigan’s 2017 Best and Brightest in Wellness® by ... Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
Breaking Medicine Technology: