Navigation Links
New UTHealth trial aimed at helping pregnant women stop smoking
Date:5/4/2011

HOUSTON (May 4, 2011) A clinical trial to test the safety and efficacy of a medication that could help pregnant women stop smoking has begun enrollment at The University of Texas Health Science Center at Houston (UTHealth).

The study targets pregnant women in their second and third trimesters when smoking can be quite harmful to the fetus, said Angela Stotts, Ph.D., associate professor in the Department of Family and Community Medicine at the UTHealth Medical School.

"Pregnant women receive counseling or self-help materials but they may need something more powerful to stop smoking. Nicotine is one of the hardest substances to quit due to its action in the brain," Stotts said.

The medication, bupropion, is known under the brand name Zyban for smoking cessation and as the antidepressant Wellbutrin in a stronger formula.

"In nonpregnant smokers, bupropion has been shown to almost double the success rate of smoking cessation and is a relatively safe medication," Stotts said. "Some obstetricians already prescribe it during pregnancy for depression."

Pregnant women who smoke are twice as likely to suffer premature rupture of membranes, placental abruption and placenta previa, according to the Centers for Disease Control and Prevention. They also have a 30 percent higher chance of delivering prematurely and their infants are up to three times more likely to die from sudden infant death syndrome. Infants born to smoking mothers also have a higher rate of low birth weight, increasing their risk for illness or death. Some studies have also linked developmental problems such as attention disorders to mothers who smoked during pregnancy.

According to a 2004 CDC report, on average, 13 percent of women continued to smoke during their pregnancy. This varies dramatically by region, however, with the South having some of the highest rates, Stotts said.

"Smoking is an addiction and women who continue to smoke during pregnancy often say they want to quit for the benefit of their baby, but just can't overcome the need. We currently don't have many pharmacological options to assist them. Therefore, I think this study is extremely important and will impact our patients in a meaningful way," said Sean Blackwell, M.D., co-investigator and associate professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at UTHealth. Blackwell is also the director of UTHealth's Larry C. Gilstrap Center for Perinatal and Women's Health Research.

A 2001 brain activation study published in the Archive of General Psychiatry concluded that bupropion appears to reduce the cravings associated with smoking. "It's an atypical antidepressant and the mechanism is not well known but we believe it works on several systems. We think it's mediated through the dopaminergic and noradrenergic systems," Stotts said. "It might act as an antagonist, blocking the effects of the nicotine, so people might not experience the same pleasant reinforcing properties of nicotine."


'/>"/>

Contact: Deborah Mann Lake
deborah.m.lake@uth.tmc.edu
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related medicine news :

1. UTHealth study: Stem cells may provide treatment for brain injuries
2. Helicobacter pylori infection linked to decreased iron levels in otherwise healthy children, according to research at UTHealth
3. UTHealth study suggests private insurers control health care spending better than Medicare
4. UTHealth receives $11 million NIDA grant
5. UTHealth researchers awarded $15 million for teen pregnancy prevention
6. UTHealth researcher receives grant for Alzheimers study
7. Sugary sports drinks mistakenly associated with being healthy, say UTHealth researchers
8. UTHealth School of Nursing to host conference on aging and abuse
9. UTHealth receives $15 million for health information technology research
10. UTHealth to serve as Health Information Technology Regional Extension Center
11. Data evaluates rehospitalization and cost burden of AFib/atrial flutter
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New UTHealth trial aimed at helping pregnant women stop smoking
(Date:7/26/2017)... (PRWEB) , ... July 26, 2017 , ... Six greater Bay Area roller derby leagues ... “Make ‘em Bleed,” the most widely attended series of blood drives in California, beginning July ... blood over the past 4 years -- enough to have helped to save up to ...
(Date:7/26/2017)... (PRWEB) , ... July 26, ... ... for Pharmaceutical Engineering (ISPE) will host its 2017 Process Validation and ... concurrent events offer comprehensive solutions to process validation lifecycle challenges faced by ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... has opened in Jupiter. The state of the art center will provide ... treatments with a goal of providing heart patients longer lives. , North American ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... specialty pharmacies, has released an updated version of the HCV Treatment Path app ... treating chronic hepatitis C virus (HCV) infection. All of the latest HCV medications ...
(Date:7/25/2017)... ... July 25, 2017 , ... Creative Pharmacist and ... provide the Pharmacist eCare Plan to Computer-Rx pharmacies through the STRAND ... ability to develop the Pharmacist eCare Plan, a shared document detailing a patient’s ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... SPRING, Md. and RESEARCH TRIANGLE ... United Therapeutics Corporation (NASDAQ: UTHR ) announced ... financial results before the market opens on Thursday, July ... Therapeutics will host a teleconference on Thursday, July 27, ... accessible by dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  ...
(Date:7/19/2017)... 19, 2017  Mako Medical Laboratories partnered with Secretary ... Family Assistance Fund (MFA) to bring 140 soldiers back ... with their families one last time before being deployed. ... travel and logistics needed for these soldiers. "Mako Medical ... their families. We just wish we could bring them ...
(Date:7/14/2017)... July 13, 2017 It should come as no ... is in the midst of a crippling opioid epidemic. ... 1999, the number of overdose deaths from opiate-based medications has ... half a million dead from 2001 to 2015". During this ... hydrocodone has similarly quadrupled, drawing a compelling link between prescription ...
Breaking Medicine Technology: