Navigation Links
New UC Davis study finds early Alzheimer's identification method
Date:7/9/2010

(SACRAMENTO, Calif.) Abnormal brain images combined with examination of the composition of the fluid that surrounds the spine may offer the earliest signs identifying healthy older adults at risk of developing Alzheimer's disease, well before cognitive problems emerge, a study by researchers at UC Davis has found.

"Our findings indicate that a distinctive pattern of imaging and biomarker deviations from typical adults may be an early warning sign of neurobiological pathology and an early sign of Alzheimer's disease," said Laurel Beckett, a professor of public health sciences at UC Davis and the lead study author. "By the time people get diagnosed with Alzheimer's using cognitive tests, there's already a lot of brain damage. We hope that in the future methods that combine brain imaging and biomarker assessments can push the diagnosis back, while learning more about the mechanisms causing Alzheimer's disease, so we can develop better treatments."

Published in the journal Neurobiology of Aging in June, the study analysis picked out a subgroup of healthy adults who later would experience a decline in memory performance typical of early Alzheimer's disease long before other study participants.

For the study, Beckett and her team used data from the Alzheimer's Disease Neuroimaging Initiative, which provides researchers with access to brain scans, clinical data and other laboratory results from spinal fluid and blood tests from more than 800 older adults. Some study participants began with a clean slate of cognitive health, some with mild cognitive impairment a condition that often presages Alzheimer's and others with mild or moderate Alzheimer's disease.

The researchers analyzed data from 220 normal older adults who had undergone structural magnetic resonance imaging (MRI) and clinical examinations. About half also provided spinal fluid samples. Among the 96 participants, cluster analysis identified three distinct subgroups of individuals based solely on their baseline imaging and laboratory measures. During the next three years, few of these healthy people showed any cognitive change. But cognitive tests for people in one of the subgroups about 10 percent of the sample declined at nearly five times the rate as healthy older adults. The researchers believe this group, which had the most extreme MRI and spinal fluid measurements, may represent the earliest stages of subclinical cognitive decline and Alzheimer's disease.

Beckett said that the finding is an important step toward discovering the constellation of imaging and fluid biomarkers that foreshadow cognitive decline, as well as a means of determining whether new treatments are effective.

"The problem with current clinical trials is that we don't know who is on the edge of experiencing dementia. And even if we did, how would we know if a treatment was working, since they haven't shown any clinical problems?" Beckett said. "This method could improve clinical trials for prevention and reduce the numbers of study participants necessary to speed drug discovery and eventually change how the pharmaceutical industry and National Institutes of Health conduct Alzheimer's disease clinical trials."


'/>"/>

Contact: Phyllis Brown
phyllis.brown@ucdmc.ucdavis.edu
916-734-9023
University of California - Davis - Health System
Source:Eurekalert

Related medicine news :

1. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
2. DavisPTnetwork Partners with the Florida Physical Therapy Association to Provide Online Continuing Education
3. DavisPTnetwork Recruits Bloggers to Report Key Session Learning Points Live from APTA 2010
4. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
5. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
6. TV drama can be more persuasive than news program, study finds
7. Study carried out into biological risks of eating reptiles
8. Neuroimaging study may pave way for effective Alzheimers treatments
9. Study finds racial gaps continue in heart disease awareness
10. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
11. First blinded study of venous insufficiency prevalence in MS shows promising results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... The International ... 7th annual “Imagine Me Beyond What You See” body image mannequin art competition. Selected ... will be showcased and the winner revealed at the 31st annual iaedp Symposium, March ...
(Date:2/24/2017)... ... ... The Radiology Business Management Association will select the 2017 ... Building Better Radiology Marketing Programs conference, held this year from March 5 to ... are given out in five categories. They are:, ,     Patient Marketing, ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... Senior International Elite division on February 12th. Ms. Esparza qualified into this ... elite qualifier competition held in Las Vegas, Nevada. Frida is one of approximately ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, the most award-winning ... Gran Fondo of Marin. For the second year in a row, cyclists will ... , “We are thrilled to provide our safe, non-toxic sunscreen to over 2,000 ...
(Date:2/23/2017)... , ... February 23, 2017 , ... The 89th Academy ... winner of the 2016 National Education Policy Center Bunkum Award. We invite you to ... 2016. , This year’s Bunkum winner is the Center for American Progress (CAP), for ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Research and Markets has announced the addition of the "Menopause Drugs ... ... Price Analysis and Strategies - 2016, provides drug pricing data and benchmarks ... What are the key drugs marketed for ... Menopause market? What are the unit prices and annual ...
(Date:2/23/2017)... , Feb. 23, 2017 Regulus Therapeutics ... discovery and development of innovative medicines targeting microRNAs, today ... 2016 financial results on Thursday, March 2, 2017 after ... conference call and webcast on March 2, 2017 at ... full year 2016 financial results and provide a general ...
(Date:2/23/2017)... -- The fast-growing cannabis market is expected to ... . According to the 2017 Legal Marijuana Outlook, published by ... 283,422 jobs by 2020, with an implied growth rate of ... The accelerating pace of cannabis legalization is considered as the ... which will further create more business ventures and boost the ...
Breaking Medicine Technology: