Navigation Links
New UAlberta research shows commonly prescribed medications could have adverse effects
Date:1/17/2013

A research team with the Faculty of Medicine & Dentistry at the University of Alberta reported findings that significantly improve understanding of how widely used drugs in Pulmonary Arterial Hypertension (PAH) affect the heart health of treated patients.

The research shows that medications often prescribed for PAH could block the function of an important hormone in the heart, decreasing the strength of contraction of the right heart chambers, a potentially important and yet unrecognized adverse effect.

PAH is a disease that affects the blood vessels of the lungs, causing a progressive narrowing and restriction of the blood flow through the lungs. This narrowing puts a significant strain in the right chamber (right ventricle) of the heart that pushes the blood through the lungs. Eventually the right ventricle fails, causing heart failure and death.

One of the causes of the narrowing of the lung blood vessels is the increased levels of endothelin in the lungs, a hormone that constricts blood vessels throughout the body. Commonly used and very expensive drugs that block the actions of endothelin, which are called endothelin receptor antagonists, or ERAs, are now used throughout the world to treat PAH patients. However, the effects of these drugs in the right ventricle had not previously been studied, until now.

Led by cardiologist Evangelos Michelakis and cardiac surgeon Jayan Nagendran's in a laboratory setting, a multidisciplinary team of cardiologists, cardiac surgeons, pathologists and scientists at the U of A studied human hearts from 50 PAH patients and laboratory models. The team showed that, while in the normal hearts, ERAs do not have significant effects because the endothelin levels are quite low, this is not the case in the diseased hearts of PAH patients. In the thickened right ventricles from PAH patients, the levels of endothelin are significantly increased.

This new finding suggests that this increase
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-399-7505
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Alternative medicine use high among children with chronic conditions: UAlberta medical research
2. Alternative medicine use high amoung children with chronic conditions: UAlberta medical research
3. UAlberta medical researchers discover new potential chemotherapy
4. UAlberta medical researchers make key discovery in fight against Alzheimers disease
5. UAlberta prostate cancer researcher and team developing homing beacon drugs to target cancer cells
6. UNC researchers use luminescent mice to track cancer and aging in real-time
7. Gothenburg researchers make world top 10
8. New research finds slower growth of preterm infants linked to altered brain development
9. Immunology research sheds new light on cell function, response
10. Autism Researchers Surprised by Impaired Brain Connections
11. Oncologist expands HPV research to anal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... ... July 02, 2015 , ... As Americans celebrate the ... hot temps, skin cancer is on the rise. July is UV Safety Month, and ... awareness about the importance of getting skin checks. Experts say most skin cancers can ...
(Date:7/2/2015)... , ... July 02, 2015 , ... Global leader and ... in compression socks designed for men. , For style that’s quick on its ... daily routine. This is great news for men everywhere because a simple change in ...
(Date:7/2/2015)... ... July 02, 2015 , ... The ZAC Foundation, a national leader in water ... lessons on how to stay water safe with the help of a young polar ... The ZAC Foundation co-founders, follows Zeke’s water safety journey. Zeke, who is afraid ...
(Date:7/2/2015)... ... July 02, 2015 , ... When The American ... the late June Web-based session, the speakers discussed the importance of accountable care ... patients through coordinated care. , During the session, participants learned the ins and ...
(Date:7/2/2015)... CA (PRWEB) , ... July 02, 2015 , ... ... of Dr. Divakar R. Krishnareddy, M.D., to the orthopedic and spine surgery team ... disc herniations, sprains, strains, bursitis, and tendonitis. Along with the spine and spine ...
Breaking Medicine News(10 mins):Health News:Local Physicians Warn of Holiday Health Hazards 2Health News:Local Physicians Warn of Holiday Health Hazards 3Health News:Local Physicians Warn of Holiday Health Hazards 4Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 3Health News:The ZAC Foundation Kicks Off Summer and July 4th Weekend with Complimentary Children’s E-Book on Water Safety 2Health News:The ZAC Foundation Kicks Off Summer and July 4th Weekend with Complimentary Children’s E-Book on Water Safety 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 2Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 4Health News:Healthpointe Welcomes Dr. Divakar R. Krishnareddy to its Orthopedic Team in Anaheim 2Health News:Healthpointe Welcomes Dr. Divakar R. Krishnareddy to its Orthopedic Team in Anaheim 3
... in how insects develop from larvae to adults have ... failure// to be effective in preventing and reducing cardiac ... Davis research published in the early online edition of ... ,The research, led by cardiologist and cell biologist Nipavan ...
... minister, Andy Kerr,has announced a computer network for the NHS, ... has been signed with a consortium of IT companies comprising ... Newell & Budge, and,will provide the NHS with national computer ... of patient records, health service payroll and nurse rosters. ...
... 39 year old woman and a mother of two children died ... a private clinic in Sheffield. //Dr.John Philip was not qualified to ... Teaching Hospitals NHS Trust, David Jackson. ,The woman who ... 1994.The doctor, John Philip told her that she was normal. When ...
... exemplary medical prowess and team effort, five concurrent kidney ... This maiden feat was accomplished with the combined effort ... took place over 10 hours and required six operating ... good health of the donors as well as the ...
... a new treatment “target” to help millions of asthma ... research on certain white cells in the body that ... experienced by asthma patients. ,The scientists, at ... Cincinnati Children’s Hospital Medical Center, report their results in ...
... Health Literacy Conference reports on the relationship between health ... could not explain why they take the prescribed medications ... they take them. About half of the adult ... research. ,Low health literacy is the degree ...
Cached Medicine News:Health News:Insect Protein Effective for Treating Heart Enlargement, Arrythmias 2Health News:Maiden Quintuple Kidney Transplant Sets a Record 2Health News:Scientists Pursue New Treatment For Asthma Sufferers 2Health News:Scientists Pursue New Treatment For Asthma Sufferers 3Health News:Low Health Literacy Is The Major Cause For Patient Errors 2
(Date:7/2/2015)... , July 2, 2015 /PRNewswire/ - ESSA Pharma Inc. ("ESSA" ... shares have been approved for listing and trading on the ... ESSA will begin trading on NASDAQ on July 9, 2015.  ... Exchange under the symbol "EPI". As a result ... each of the Company,s outstanding special warrants issued on January ...
(Date:7/2/2015)... July 2, 2015  Fort Lauderdale-based investment banking ... announce that its Consumer Group completed the sale ... Group plc (ISE: KRZ) ("Kerry"), one of the ... systems, as well as functional ingredients and actives ... Farlie Turner served as the exclusive financial advisor ...
(Date:7/2/2015)... NEW YORK , July 2, 2015 /PRNewswire/ ... of a conspicuously high-growth market segment in hematology ... research publisher said that Roche,s recent unveiling of its ... into the cobas m 511 hematology ... not only capture growth enjoyed by current leader ...
Breaking Medicine Technology:ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4Farlie Turner's Consumer Group Completes Sale of Insight Beverages to Kerry 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 3
... percent of patients treated with VELCADE, cyclophosphamide,and ... Greece, June 28, 2007 /PRNewswire-FirstCall/ -- Millennium,Pharmaceuticals, ... results,from clinical trials of VELCADE based therapies ... (CR) rates in previously,treated multiple myeloma (MM) ...
... 29, 2007 /PRNewswire/ --,The European Myeloma Platform (EMP) ... (lenalidomide) plus the,steroid dexamethasone shows median survival of ... from two large randomized,controlled Phase III trials that ... sites worldwide. These updated results,were presented at the ...
Cached Medicine Technology:Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 2Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 3Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 4Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 5Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 6The European Myeloma Platform Reports New Survival data for,Revlimid Presented at the International Myeloma Workshop in Greece 2
... Powerful and Flexible Impact And Impact2 Pipettors ... volume ranges, our single channel Impact and ... of any application. Engineered with the same ... multichannel line, these pipettors are equally easy ...
... The total ergonomic solution and best ... Soft, feather touch action and ultra ... strain, Stress-free tip ejection with long, ... easy volume identification, Accepts universal tips ...
The Biopette E has a comfortable, ergonomic design. Fully motorized piston drive. Virtually eliminates pipetting forces. User-friendly operator interface. Simple, precise volume setting. Rechargelabl...
Inquire...
Medicine Products: