Navigation Links
New UAlberta research shows commonly prescribed medications could have adverse effects
Date:1/17/2013

A research team with the Faculty of Medicine & Dentistry at the University of Alberta reported findings that significantly improve understanding of how widely used drugs in Pulmonary Arterial Hypertension (PAH) affect the heart health of treated patients.

The research shows that medications often prescribed for PAH could block the function of an important hormone in the heart, decreasing the strength of contraction of the right heart chambers, a potentially important and yet unrecognized adverse effect.

PAH is a disease that affects the blood vessels of the lungs, causing a progressive narrowing and restriction of the blood flow through the lungs. This narrowing puts a significant strain in the right chamber (right ventricle) of the heart that pushes the blood through the lungs. Eventually the right ventricle fails, causing heart failure and death.

One of the causes of the narrowing of the lung blood vessels is the increased levels of endothelin in the lungs, a hormone that constricts blood vessels throughout the body. Commonly used and very expensive drugs that block the actions of endothelin, which are called endothelin receptor antagonists, or ERAs, are now used throughout the world to treat PAH patients. However, the effects of these drugs in the right ventricle had not previously been studied, until now.

Led by cardiologist Evangelos Michelakis and cardiac surgeon Jayan Nagendran's in a laboratory setting, a multidisciplinary team of cardiologists, cardiac surgeons, pathologists and scientists at the U of A studied human hearts from 50 PAH patients and laboratory models. The team showed that, while in the normal hearts, ERAs do not have significant effects because the endothelin levels are quite low, this is not the case in the diseased hearts of PAH patients. In the thickened right ventricles from PAH patients, the levels of endothelin are significantly increased.

This new finding suggests that this increase
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-399-7505
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Alternative medicine use high among children with chronic conditions: UAlberta medical research
2. Alternative medicine use high amoung children with chronic conditions: UAlberta medical research
3. UAlberta medical researchers discover new potential chemotherapy
4. UAlberta medical researchers make key discovery in fight against Alzheimers disease
5. UAlberta prostate cancer researcher and team developing homing beacon drugs to target cancer cells
6. UNC researchers use luminescent mice to track cancer and aging in real-time
7. Gothenburg researchers make world top 10
8. New research finds slower growth of preterm infants linked to altered brain development
9. Immunology research sheds new light on cell function, response
10. Autism Researchers Surprised by Impaired Brain Connections
11. Oncologist expands HPV research to anal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... October 01, 2014 Insuranceragents.info has ... a good life insurance plan for vulnerable family members. ... vulnerable family members. Providers in the family should always ... cause financial hardships for the rest of the family. ... policies. Families can benefit more from temporary coverage or ...
(Date:10/1/2014)... October 01, 2014 Phoseon Technology, the ... continues to expand the business worldwide. This rapid growth ... additional capacity for manufacturing efforts. The company has experienced ... five years and expects this growth to continue in ... technology gains worldwide adoption. , “We are very ...
(Date:10/1/2014)... A new genetic finding from Duke Medicine suggests that ... depression might also be hard-wired to gain weight when ... disease. , An estimated 13 percent of people, all ... and knowing this could help them reduce heart disease ... and stress management. , "Genetic susceptibility, psychosocial stress and ...
(Date:10/1/2014)... Jersey City, NJ (PRWEB) October 01, 2014 ... sticking with their intentions to lose weight and their dieting ... in unhealthy, fatty foods. Including hormone diet treatments ... not only allows patients to see fast and effective weight ... diet and begin forming healthy habits to maintain their weight ...
(Date:10/1/2014)... 2014 On Sept. 9, Chapín Coffee ... the Martha Stewart American Made Awards (MSAMAs), an annual ... country in the fields of crafts, design, food and ... a finalist in the MSAMAs, which celebrates entrepreneurs and ... improving local communities and changing the way we shop, ...
Breaking Medicine News(10 mins):Health News:Life Insurance for Families - Clients Can Compare Affordable Rates Online! 2Health News:Phoseon Technology Continues to Drive Growth Worldwide 2Health News:Gene interacts with stress and leads to heart disease in some people 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Chicago Coffee Start-up Makes a Big Impact, Earns National Recognition 2
... the form of percutaneous coronary intervention (PCI) is now ... infarction. New European guidelines issued in November 2008 emphasised ... to restore blood flow to the heart and improve ... in patients with stable coronary artery disease; PCI has ...
... Construction Company, the nation,s leading builder of healthcare facilities, ... proceed with the $42 million Phase Two expansion to ... start in March 2009 with completion scheduled for March ... plant, emergency rooms, ICU, CCU, three operating rooms and ...
... PARK, Ill., Feb. 6 Abbott ( NYSE: ABT ... Antitrust,Improvements Act of 1976 (HSR) applicable to Abbott,s cash ... common stock of Advanced Medical,Optics (AMO) expired last night ... The expiration of the HSR waiting period satisfies ...
... of 7 HIV+ Patients Receiving Dapsone Therapy at Significant ... IRVINE, Calif., Feb. 6 Masimo (Nasdaq: ... Motion and Low-Perfusion pulse oximetry, today announced that a ... Medicine 38th Critical Care Congress suggests providers should consider ...
... revenues increase by 35% over same period in ... are in Canadian dollars unless otherwise noted),BELLEVILLE, ON, ... (TSX: BNC), a research-based, technology-driven Canadian biopharmaceutical company, ... of its 2009 fiscal year, ending December 31, ...
... a new study shows that losing weight is perhaps the ... disorders, according to a new study in the American ... the American Thoracic Society,s three peer-reviewed journals. , Weight ... fancy high-tech treatment, but it is an exciting therapy for ...
Cached Medicine News:Health News:Efficacy of stents is improved when their placement is determined by arterial blood flow measurement 2Health News:Turner to Manage Construction of $42 Million Expansion of Northern Inyo Hospital in Bishop, Calif. 2Health News:Abbott Acquisition of Advanced Medical Optics Clears U.S. Antitrust Review 2Health News:Abbott Acquisition of Advanced Medical Optics Clears U.S. Antitrust Review 3Health News:New Clinical Study Presented at the Society for Critical Care Medicine Shows Value of Pulse CO-Oximetry(TM) to Identify Acquired Methemoglobinemia 2Health News:New Clinical Study Presented at the Society for Critical Care Medicine Shows Value of Pulse CO-Oximetry(TM) to Identify Acquired Methemoglobinemia 3Health News:New Clinical Study Presented at the Society for Critical Care Medicine Shows Value of Pulse CO-Oximetry(TM) to Identify Acquired Methemoglobinemia 4Health News:Bioniche Reports Fiscal 2009 Second Quarter 2Health News:Bioniche Reports Fiscal 2009 Second Quarter 3Health News:Bioniche Reports Fiscal 2009 Second Quarter 4Health News:Bioniche Reports Fiscal 2009 Second Quarter 5Health News:Bioniche Reports Fiscal 2009 Second Quarter 6Health News:Bioniche Reports Fiscal 2009 Second Quarter 7Health News:Bioniche Reports Fiscal 2009 Second Quarter 8Health News:Bioniche Reports Fiscal 2009 Second Quarter 9Health News:Losing weight can cure obstructive sleep apnea in overweight patients 2
(Date:9/30/2014)... BEDFORD, Mass. , Sept. 30, 2014  Hologic, ... Stephen MacMillan , Hologic,s President and Chief Executive ... Bell Ceremony on October 1, the first day of ... will discuss the Company,s campaign focused on the important ... system approved by the FDA as clinically superior to ...
(Date:9/30/2014)... , Sept. 30, 2014 STUDY OBJECTIVES ... study is to provide an overview of the ... for protein drugs/therapeutics. The key objective is to ... protein drugs as an important tool in the ... present and future strategies within the protein therapeutics ...
(Date:9/30/2014)... Mass. , Sept. 30, 2014  Decision Resources Group finds ... Australia , China , ... Korea—will expand at a strong rate through 2023. Dental implant procedure ... and as patient awareness rises. Other key findings from ... dental implant market: , Dental implant penetration: ...
Breaking Medicine Technology:Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3
... sensitivity (threshold) testing provides clinically beneficial ... ophthalmic conditions. Dark adaptometry is useful ... retinal degenerations, senile miosis, high myopia, ... conditions, while whole-field scotopic sensitivity has ...
... The MFERG is available in conjunction with ... UTAS-E3000mf or EPIC-4000 or as a stand-alone ... visual electrodiagnostic test uses a software controlled ... to stimulate many areas of the retina ...
... Amplifier (UBA-4204) from LKC Technologies, ... amplification and complete electrical isolation ... problems of DC drifting, 50/60Hz ... make the amplifier ideal for ...
... to facilitate an arthrodesis, either by an ... cages allowing radicular compression by restoring the ... of the foramina, which in turn enhances ... major lumbar instabilities.,CC cages are made of ...
Medicine Products: