Navigation Links
New Type of Cholesterol-Lowering Drug Shows Promise
Date:12/18/2007

Experimental agent works differently than statin medications, researchers say

TUESDAY, Dec. 18 (HealthDay News) -- A new kind of drug designed to lower levels of "bad" low-density lipoprotein (LDL) cholesterol and reduce heart disease risk has proved safe and effective in a phase II clinical trial, researchers report.

Elevated LDL levels increase the risk of heart attack and stroke.

The small study of 24 moderately overweight people with high LDL levels found that the drug (KB2115) helped reduced LDL levels by as much as 40 percent. The findings confirm earlier tests in animals. The drug was well tolerated, and there were no detectable effects on the heart.

All the American and Swedish researchers involved in the study have a proprietary interest in Swedish pharmaceutical company Karo Bio AB, which developed KB2115. The research was conducted at the Karolinska Institute, Stockholm, and the University of California, San Francisco.

The drug is designed to mimic the action of thyroid hormone and accelerates the hormone's natural ability to rid the body of LDL. Since it is unrelated in structure or action to widely-used cholesterol lowering statin drugs (such as Lipitor, Pravachol and Zocor), KB2115 may offer an alternative for patients who can't tolerate statins, according to the study authors. It may also be possible to use KB2115 to further decrease cholesterol levels in patients taking statins.

The results were published online this week in the journal Proceedings of the National Academy of Sciences.

More information

The American Heart Association has more about cholesterol.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, Dec. 17, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cholesterol-lowering drug linked to sleep disruptions
2. Many Patients Stop Taking Cholesterol-Lowering Drugs
3. New study shows promise in reducing surgical risks associated with surgical bleeding
4. New research shows how chronic stress worsens neurodegenerative disease course
5. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
6. Circulating fats kill transplanted pancreas cells, study shows
7. New Heart Pump Shows Promise in Trial
8. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
9. New Survey Shows Americans are Still Concerned About Food Safety, Yet Still Not Smart About What They Like to Eat
10. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
11. Amid Improving Life Expectancy Rates, Risk of Premature Death is Still Significant for Americans, New Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Story Highlights: ... within the health care industry is causing providers to ... , Deloitte offers a suite of solutions for health ... efficient cost optimization: labor resource analysis, revenue cycle optimization ... better outcomes and better economics ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
Breaking Medicine Technology: