Navigation Links
New Type of Cholesterol-Lowering Drug Shows Promise
Date:12/18/2007

Experimental agent works differently than statin medications, researchers say

TUESDAY, Dec. 18 (HealthDay News) -- A new kind of drug designed to lower levels of "bad" low-density lipoprotein (LDL) cholesterol and reduce heart disease risk has proved safe and effective in a phase II clinical trial, researchers report.

Elevated LDL levels increase the risk of heart attack and stroke.

The small study of 24 moderately overweight people with high LDL levels found that the drug (KB2115) helped reduced LDL levels by as much as 40 percent. The findings confirm earlier tests in animals. The drug was well tolerated, and there were no detectable effects on the heart.

All the American and Swedish researchers involved in the study have a proprietary interest in Swedish pharmaceutical company Karo Bio AB, which developed KB2115. The research was conducted at the Karolinska Institute, Stockholm, and the University of California, San Francisco.

The drug is designed to mimic the action of thyroid hormone and accelerates the hormone's natural ability to rid the body of LDL. Since it is unrelated in structure or action to widely-used cholesterol lowering statin drugs (such as Lipitor, Pravachol and Zocor), KB2115 may offer an alternative for patients who can't tolerate statins, according to the study authors. It may also be possible to use KB2115 to further decrease cholesterol levels in patients taking statins.

The results were published online this week in the journal Proceedings of the National Academy of Sciences.

More information

The American Heart Association has more about cholesterol.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, Dec. 17, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cholesterol-lowering drug linked to sleep disruptions
2. Many Patients Stop Taking Cholesterol-Lowering Drugs
3. New study shows promise in reducing surgical risks associated with surgical bleeding
4. New research shows how chronic stress worsens neurodegenerative disease course
5. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
6. Circulating fats kill transplanted pancreas cells, study shows
7. New Heart Pump Shows Promise in Trial
8. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
9. New Survey Shows Americans are Still Concerned About Food Safety, Yet Still Not Smart About What They Like to Eat
10. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
11. Amid Improving Life Expectancy Rates, Risk of Premature Death is Still Significant for Americans, New Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/10/2017)...  NDS received FDA 510(k) clearance in May 2017 for its ... specifically designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... to support the improvement of patient outcomes, procedural efficiency, and the ... ... ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
Breaking Medicine Technology: