Navigation Links
New Tumor Marker May Improve Cancer Detection: Study
Date:10/20/2010

WEDNESDAY, Oct. 20 (HealthDay News) -- A hormone receptor normally confined to the reproductive organs has been detected in malignant tumors in many parts of the body, researchers report.

Researchers from the Mt. Sinai School of Medicine in New York City, working with French government scientists, say this common link may offer a new target for the early diagnosis and treatment of cancer.

They evaluated tumor tissue samples from 1,336 men and women with 11 common cancers, including prostate, breast, colon, pancreatic, lung, liver and ovarian. The analyses revealed the presence of the follicle-stimulating hormone (FSH) receptor in the blood vessel cells of the tumors.

This receptor is not found on blood vessels in normal tissue, with the exception of the reproductive organs, where it is present in much lower concentrations than in tumors, said the American and French researchers. (In women, FSH, which interacts with the FSH-receptor, normally helps control the menstrual cycle and egg production; in men, FSH normally helps control the production of sperm.)

Activating the FSH receptor contributes to the signaling of a protein (VEGF) that stimulates the growth of blood vessels, including those in tumors. Blocking the action of the FSH receptor may also block the signaling of VEGF.

"This new tumor marker may be used to improve cancer detection," study lead author Aurelian Radu, an assistant professor of developmental and regenerative biology at Mount Sinai School of Medicine, said in a Mount Sinai Medical Center news release.

"Tumor imaging agents that bind to the new marker could be injected in the [body's blood vessel system] and would make visible early tumors located anywhere in the body using magnetic resonance imaging, positron emission tomography, or ultrasound imaging," Radu explained.

In addition, new treatments "can be developed that will block the tumor blood supply, either by inhibiting formation of new blood vessels, blocking the blood flow by coagulation, or by destroying the existing tumor vessels."

The study appears in the Oct. 21 issue of the The New England Journal of Medicine.

More information

The U.S. National Cancer Institute has more about treatments that target tumor blood vessels.

-- Robert Preidt

SOURCE: Mount Sinai Medical Center, news release, Oct. 20, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Girls with ovarian germ-cell tumors can safely skip chemotherapy unless disease recurs
2. Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
3. Mayo Clinic finds early success with laser that destroys tumors with heat
4. Phase III study shows everolimus delays tumor progression in hard-to-treat neuroendocrine tumors
5. Experimental Drug Aids Kids With Nervous System Tumor
6. Circulating tumor cells can provide real-time information on patients current disease state
7. Individual mutations are very slow to promote tumor growth
8. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
9. University Hospitals Case Medical Center implements AutoLITT system for treatment of brain tumors
10. Selective inhibition of BMK1 suppresses tumor growth
11. Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Tumor Marker May Improve Cancer Detection: Study
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced ... attorneys chosen by their peers for this recognition are considered among the top 2 ... received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... , ... Comfort Keepers® of San Diego, CA is excited to announce they ... to drive cancer patients to and from their cancer treatments. Comfort Keepers provides ... life and ongoing independence. Getting to and from medical treatments is one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
Breaking Medicine Technology: