Navigation Links
New Tumor Marker May Improve Cancer Detection: Study
Date:10/20/2010

WEDNESDAY, Oct. 20 (HealthDay News) -- A hormone receptor normally confined to the reproductive organs has been detected in malignant tumors in many parts of the body, researchers report.

Researchers from the Mt. Sinai School of Medicine in New York City, working with French government scientists, say this common link may offer a new target for the early diagnosis and treatment of cancer.

They evaluated tumor tissue samples from 1,336 men and women with 11 common cancers, including prostate, breast, colon, pancreatic, lung, liver and ovarian. The analyses revealed the presence of the follicle-stimulating hormone (FSH) receptor in the blood vessel cells of the tumors.

This receptor is not found on blood vessels in normal tissue, with the exception of the reproductive organs, where it is present in much lower concentrations than in tumors, said the American and French researchers. (In women, FSH, which interacts with the FSH-receptor, normally helps control the menstrual cycle and egg production; in men, FSH normally helps control the production of sperm.)

Activating the FSH receptor contributes to the signaling of a protein (VEGF) that stimulates the growth of blood vessels, including those in tumors. Blocking the action of the FSH receptor may also block the signaling of VEGF.

"This new tumor marker may be used to improve cancer detection," study lead author Aurelian Radu, an assistant professor of developmental and regenerative biology at Mount Sinai School of Medicine, said in a Mount Sinai Medical Center news release.

"Tumor imaging agents that bind to the new marker could be injected in the [body's blood vessel system] and would make visible early tumors located anywhere in the body using magnetic resonance imaging, positron emission tomography, or ultrasound imaging," Radu explained.

In addition, new treatments "can be developed that will block the tumor blood supply, either by inhibiting formation of new blood vessels, blocking the blood flow by coagulation, or by destroying the existing tumor vessels."

The study appears in the Oct. 21 issue of the The New England Journal of Medicine.

More information

The U.S. National Cancer Institute has more about treatments that target tumor blood vessels.

-- Robert Preidt

SOURCE: Mount Sinai Medical Center, news release, Oct. 20, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Girls with ovarian germ-cell tumors can safely skip chemotherapy unless disease recurs
2. Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
3. Mayo Clinic finds early success with laser that destroys tumors with heat
4. Phase III study shows everolimus delays tumor progression in hard-to-treat neuroendocrine tumors
5. Experimental Drug Aids Kids With Nervous System Tumor
6. Circulating tumor cells can provide real-time information on patients current disease state
7. Individual mutations are very slow to promote tumor growth
8. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
9. University Hospitals Case Medical Center implements AutoLITT system for treatment of brain tumors
10. Selective inhibition of BMK1 suppresses tumor growth
11. Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Tumor Marker May Improve Cancer Detection: Study
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
(Date:6/24/2016)... Washington, D.C. (PRWEB) , ... June 24, 2016 , ... ... Pro-Am Heroes Golf Classic Tournament held on June 20th at the Woodmont Country ... local charity, Luke’s Wings, an organization dedicated to helping service members that have been ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: