Navigation Links
New Tumor Marker May Improve Cancer Detection: Study

WEDNESDAY, Oct. 20 (HealthDay News) -- A hormone receptor normally confined to the reproductive organs has been detected in malignant tumors in many parts of the body, researchers report.

Researchers from the Mt. Sinai School of Medicine in New York City, working with French government scientists, say this common link may offer a new target for the early diagnosis and treatment of cancer.

They evaluated tumor tissue samples from 1,336 men and women with 11 common cancers, including prostate, breast, colon, pancreatic, lung, liver and ovarian. The analyses revealed the presence of the follicle-stimulating hormone (FSH) receptor in the blood vessel cells of the tumors.

This receptor is not found on blood vessels in normal tissue, with the exception of the reproductive organs, where it is present in much lower concentrations than in tumors, said the American and French researchers. (In women, FSH, which interacts with the FSH-receptor, normally helps control the menstrual cycle and egg production; in men, FSH normally helps control the production of sperm.)

Activating the FSH receptor contributes to the signaling of a protein (VEGF) that stimulates the growth of blood vessels, including those in tumors. Blocking the action of the FSH receptor may also block the signaling of VEGF.

"This new tumor marker may be used to improve cancer detection," study lead author Aurelian Radu, an assistant professor of developmental and regenerative biology at Mount Sinai School of Medicine, said in a Mount Sinai Medical Center news release.

"Tumor imaging agents that bind to the new marker could be injected in the [body's blood vessel system] and would make visible early tumors located anywhere in the body using magnetic resonance imaging, positron emission tomography, or ultrasound imaging," Radu explained.

In addition, new treatments "can be developed that will block the tumor blood supply, either by inhibiting formation of new blood vessels, blocking the blood flow by coagulation, or by destroying the existing tumor vessels."

The study appears in the Oct. 21 issue of the The New England Journal of Medicine.

More information

The U.S. National Cancer Institute has more about treatments that target tumor blood vessels.

-- Robert Preidt

SOURCE: Mount Sinai Medical Center, news release, Oct. 20, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Girls with ovarian germ-cell tumors can safely skip chemotherapy unless disease recurs
2. Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
3. Mayo Clinic finds early success with laser that destroys tumors with heat
4. Phase III study shows everolimus delays tumor progression in hard-to-treat neuroendocrine tumors
5. Experimental Drug Aids Kids With Nervous System Tumor
6. Circulating tumor cells can provide real-time information on patients current disease state
7. Individual mutations are very slow to promote tumor growth
8. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
9. University Hospitals Case Medical Center implements AutoLITT system for treatment of brain tumors
10. Selective inhibition of BMK1 suppresses tumor growth
11. Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
Post Your Comments:
Related Image:
New Tumor Marker May Improve Cancer Detection: Study
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
Breaking Medicine Technology: