Navigation Links
New Tumor Marker May Improve Cancer Detection: Study
Date:10/20/2010

WEDNESDAY, Oct. 20 (HealthDay News) -- A hormone receptor normally confined to the reproductive organs has been detected in malignant tumors in many parts of the body, researchers report.

Researchers from the Mt. Sinai School of Medicine in New York City, working with French government scientists, say this common link may offer a new target for the early diagnosis and treatment of cancer.

They evaluated tumor tissue samples from 1,336 men and women with 11 common cancers, including prostate, breast, colon, pancreatic, lung, liver and ovarian. The analyses revealed the presence of the follicle-stimulating hormone (FSH) receptor in the blood vessel cells of the tumors.

This receptor is not found on blood vessels in normal tissue, with the exception of the reproductive organs, where it is present in much lower concentrations than in tumors, said the American and French researchers. (In women, FSH, which interacts with the FSH-receptor, normally helps control the menstrual cycle and egg production; in men, FSH normally helps control the production of sperm.)

Activating the FSH receptor contributes to the signaling of a protein (VEGF) that stimulates the growth of blood vessels, including those in tumors. Blocking the action of the FSH receptor may also block the signaling of VEGF.

"This new tumor marker may be used to improve cancer detection," study lead author Aurelian Radu, an assistant professor of developmental and regenerative biology at Mount Sinai School of Medicine, said in a Mount Sinai Medical Center news release.

"Tumor imaging agents that bind to the new marker could be injected in the [body's blood vessel system] and would make visible early tumors located anywhere in the body using magnetic resonance imaging, positron emission tomography, or ultrasound imaging," Radu explained.

In addition, new treatments "can be developed that will block the tumor blood supply, either by inhibiting formation of new blood vessels, blocking the blood flow by coagulation, or by destroying the existing tumor vessels."

The study appears in the Oct. 21 issue of the The New England Journal of Medicine.

More information

The U.S. National Cancer Institute has more about treatments that target tumor blood vessels.

-- Robert Preidt

SOURCE: Mount Sinai Medical Center, news release, Oct. 20, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Girls with ovarian germ-cell tumors can safely skip chemotherapy unless disease recurs
2. Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
3. Mayo Clinic finds early success with laser that destroys tumors with heat
4. Phase III study shows everolimus delays tumor progression in hard-to-treat neuroendocrine tumors
5. Experimental Drug Aids Kids With Nervous System Tumor
6. Circulating tumor cells can provide real-time information on patients current disease state
7. Individual mutations are very slow to promote tumor growth
8. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
9. University Hospitals Case Medical Center implements AutoLITT system for treatment of brain tumors
10. Selective inhibition of BMK1 suppresses tumor growth
11. Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Tumor Marker May Improve Cancer Detection: Study
(Date:4/24/2017)... ... ... Veteran Theresa James awoke to the sound of her newly ex-husband breaking into ... depicts every parent’s worst nightmare, when her three children were violently taken from her. ... my divorce,” James said. “After the death of my children, I continued to journal. ...
(Date:4/24/2017)... , ... April 24, 2017 , ... ... of unique liquid food supplements, announced its popular products are now available for ... , ALP Nutrition® prioritizes the use of premium natural ingredients in making all ...
(Date:4/24/2017)... Raton, Florida (PRWEB) , ... April 24, 2017 , ... ... chai teas, announced its products are now available for purchase on RevNutrition.com, a popular ... form of tea first produced and popularized in ancient India and Siam. It spread ...
(Date:4/24/2017)... , ... April 24, 2017 , ... ... healthcare compliance and credentialing solutions, today announced that Kyle Allain has joined the ... Cactus Provider Management sales and operations, including provider, payor and managed care solutions. ...
(Date:4/24/2017)... ... April 24, 2017 , ... In 2017, up to 78,000 ... 25,000 of them will be malignant.(1) As research into precision medicine continues, both ... model in the diagnosis and treatment of brain tumors. Healthcare facilities that are ...
Breaking Medicine News(10 mins):
(Date:4/24/2017)... 24, 2017 Solentim, the developer of ... addition of a major new product line called ... The VIPS has been developed for automatically seeding ... as part of the process to generate clonally-derived ... and more reliable solution when compared to traditional ...
(Date:4/20/2017)... Texas , April 20, 2017  Vivify Health, ... mobile devices, has been awarded a very significant patent ... via EMRs to continual care via digital health.  This ... key intellectual property and further secures Vivify,s position as ... launched in 2009, was the first company to apply ...
(Date:4/20/2017)... , April 20, 2017  RXi Pharmaceuticals ... innovative therapeutics that address significant unmet medical needs, ... from the Company,s consumer product development program, based ... the Society for Investigative Dermatology (SID) 76 th ... advance and promote the sciences relevant to skin ...
Breaking Medicine Technology: