Navigation Links
New Treatment Shows Promise for Excessive Drinking

Boosting brain protein in animal study cut desire, relapse in as little as 10 minutes

TUESDAY, June 10 (HealthDay News) -- A new treatment that reduces excessive drinking and prevents drinking relapse proved successful in tests on rats, a new study finds.

The treatment involves increasing levels of a brain protein called glial cell-derived neurotrophic factor (GDNF) -- also being looked at as a treatment for Parkinson's disease. The researchers also pinpointed the site in the brain where GDNF acts to control drinking.

In addition, the treatment didn't block other normal pleasure-seeking behaviors (such as craving sweets), a common problem with drugs developed to treat alcoholism.

In this study, rats were conditioned for two months to seek alcohol. The researchers then injected GDNF into a brain region called the Ventral Tegmental Area (VTA), which is believed to be strongly involved in drug-seeking behavior. The rats' desire to drink alcohol decreased significantly within as little as 10 minutes, and the effect lasted at least three hours.

But the rats still wanted to drink sugar water after the injections of GDNF, which shows that increased levels of GDNF didn't decrease this pleasure-seeking behavior.

In another part of the study, the researchers trained rats to desire alcohol and then took it away from them. When alcohol was reintroduced, the rats started drinking the same amount as before. But when they were treated with GDNF, they lost their taste for alcohol.

The study was published in this week's issue of the Proceedings of the National Academy of Sciences.

"Alcoholism is a devastating and costly psychiatric disease with enormous socioeconomic impact. There is tremendous need for therapies to treat alcohol abuse," study senior author Dorit Ron, principal investigator at the University of California, San Francisco-affiliated Ernest Gallo Clinic and Research Center, said in a prepared statement.

"Unfortunately, only three drugs are currently approved to treat excessive drinking, and all have serious limitations. Our findings open the door to a promising new strategy to combat alcohol abuse, addiction and especially relapse," Ron said.

More information

The American Psychological Association has more about alcohol use disorders and their treatment.

-- Robert Preidt

SOURCE: University of California, San Francisco, news release, June 9, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. The Monoclonal Antibodies Drug Market for the Treatment of Cancer Will More Than Double to $16.7 Billion By 2016
2. Treatment at an AASM accredited sleep center improves long-term CPAP compliance
3. TB treatment for the elderly likely requires a boost to immune response
4. Botox and Restylane Not A Destination or Spa Treatment
5. WHO Report Says 9.7 Million at Risk of Death from AIDS Today; AHF Renews Call for US Congress to Commit to Scale up Treatment to Seven Million Lives
6. Celebrate Swedish Breaks Record Again; Helps Launch Center for Advanced Brain Tumor Treatment
7. AstraZeneca submits an sNDA for Symbicort for treatment of asthma in children as young as 6
8. New Program/Website Targets Jewish Children, Teens, and Adults Suffering from the Impact of Childhood Maltreatment
9. Treatment improves walking ability of Parkinsons patients
10. New model predicts whether patients will be free of renal cancer 12 years after initial treatment
11. Five-Year Cancer Survivors Will Celebrate Life(R) at Cancer Treatment Centers of America(R)
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: