Navigation Links
New Treatment Shows Promise for Excessive Drinking
Date:6/10/2008

Boosting brain protein in animal study cut desire, relapse in as little as 10 minutes

TUESDAY, June 10 (HealthDay News) -- A new treatment that reduces excessive drinking and prevents drinking relapse proved successful in tests on rats, a new study finds.

The treatment involves increasing levels of a brain protein called glial cell-derived neurotrophic factor (GDNF) -- also being looked at as a treatment for Parkinson's disease. The researchers also pinpointed the site in the brain where GDNF acts to control drinking.

In addition, the treatment didn't block other normal pleasure-seeking behaviors (such as craving sweets), a common problem with drugs developed to treat alcoholism.

In this study, rats were conditioned for two months to seek alcohol. The researchers then injected GDNF into a brain region called the Ventral Tegmental Area (VTA), which is believed to be strongly involved in drug-seeking behavior. The rats' desire to drink alcohol decreased significantly within as little as 10 minutes, and the effect lasted at least three hours.

But the rats still wanted to drink sugar water after the injections of GDNF, which shows that increased levels of GDNF didn't decrease this pleasure-seeking behavior.

In another part of the study, the researchers trained rats to desire alcohol and then took it away from them. When alcohol was reintroduced, the rats started drinking the same amount as before. But when they were treated with GDNF, they lost their taste for alcohol.

The study was published in this week's issue of the Proceedings of the National Academy of Sciences.

"Alcoholism is a devastating and costly psychiatric disease with enormous socioeconomic impact. There is tremendous need for therapies to treat alcohol abuse," study senior author Dorit Ron, principal investigator at the University of California, San Francisco-affiliated Ernest Gallo Clinic and Research Center, said in a prepared statement.

"Unfortunately, only three drugs are currently approved to treat excessive drinking, and all have serious limitations. Our findings open the door to a promising new strategy to combat alcohol abuse, addiction and especially relapse," Ron said.

More information

The American Psychological Association has more about alcohol use disorders and their treatment.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, June 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. The Monoclonal Antibodies Drug Market for the Treatment of Cancer Will More Than Double to $16.7 Billion By 2016
2. Treatment at an AASM accredited sleep center improves long-term CPAP compliance
3. TB treatment for the elderly likely requires a boost to immune response
4. Botox and Restylane Not A Destination or Spa Treatment
5. WHO Report Says 9.7 Million at Risk of Death from AIDS Today; AHF Renews Call for US Congress to Commit to Scale up Treatment to Seven Million Lives
6. Celebrate Swedish Breaks Record Again; Helps Launch Center for Advanced Brain Tumor Treatment
7. AstraZeneca submits an sNDA for Symbicort for treatment of asthma in children as young as 6
8. New Program/Website Targets Jewish Children, Teens, and Adults Suffering from the Impact of Childhood Maltreatment
9. Treatment improves walking ability of Parkinsons patients
10. New model predicts whether patients will be free of renal cancer 12 years after initial treatment
11. Five-Year Cancer Survivors Will Celebrate Life(R) at Cancer Treatment Centers of America(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... (PRWEB) , ... February 27, 2017 , ... ... mass and overall body strength, which often leads to a host of health ... Journal of the American Geriatrics Society discovered that good overall muscle strength ...
(Date:2/27/2017)... ... February 27, 2017 , ... Robert E. Burke, MD, PhD, had ... his impoverished upbringing and life experiences could have led him down a much different ... Inspirational Tales of Parenting, Perseverance and Pediatrics,” Dr. Burke shares a personal account of ...
(Date:2/27/2017)... , ... February 27, 2017 , ... Much attention has ... for women who become dependent on opioid painkillers has fallen short. From 1999 until ... to a 237% increase in fatal overdoses in male populations.(1) , The proportion of ...
(Date:2/27/2017)... , ... February 27, 2017 , ... Elisa Guajardo Carothers is not your typical author. ... studying to become a nun. Now, she writes about God, when she isn’t swimming as ... BC and AD, Here is BS! (Before Satan),” she offers a comedic look at the ...
(Date:2/27/2017)... Yorba Linda, Ca (PRWEB) , ... February 27, ... ... Coulter Life Sciences, provides an overview on laser diffraction analysis as a tool ... highlighting its capabilities, significance and potential to obtain improved results and novel scientific ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... YORK , Feb. 27, 2017 /PRNewswire/ ... Michael P. Vallely , MBBS, PhD, FRACS, of  ... University of Sydney will be published ...  Journal of the American College of Cardiology ... "no-touch" beating heart bypass surgery technique (anOPCABG) ...
(Date:2/27/2017)... Feb. 27, 2017  International Biophysics Corporation, a global medical ... today announced a 34% revenue growth in 2016 when compared ... unit sales.  This growth was fueled by its AffloVest® sales ... to the expansion of its global sales of surgical product ... CEO, "As we enter our 25 th year in ...
(Date:2/27/2017)... , Feb. 27, 2017  RegeneRx Biopharmaceuticals, ... clinical-stage drug development company focused on tissue protection, ... for RGN-137, GtreeBNT Co., Ltd., received a positive ... 3 clinical trial design for RGN-137 to treat ... healing gel that incorporates Thymosin beta 4 ("Tß4") ...
Breaking Medicine Technology: