Navigation Links
New Therapy Kills Human Leukemia Cells in Mice
Date:5/16/2008

Technique expands natural killer cells in cord blood more than 30-fold

FRIDAY, May 16 (HealthDay News) A treatment that uses natural killer (NK) immune system cells from umbilical cord blood effectively destroys human leukemia cells in mice, researchers say.

The NK cells reduced by 60 percent to 85 percent human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells in test mice with aggressive human leukemias, according to the study.

The findings are to be presented at the May 16 American Society of Pediatric Hematology/Oncology annual conference, in Cincinnati.

Previous efforts like this one, which require the number of NK cells from a single cord blood to be expanded, resulted in ineffective NK cells. The new technique manages to increase NK cells in cord blood more than 30-fold while allowing the cells to retain their ability to target and kill acute leukemia cells.

"Cord blood is a promising source of natural killer cells, because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," investigator Dr. Patrick Zweidler-McKay, assistant professor of pediatrics from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center, said in a prepared statement.

Graft-versus-host disease is a common side effect of patients receiving stem cell transplants. It is fatal if not controlled.

The new process allows the NK cells to be transplanted to leukemia patients without the need for prior chemotherapy. Zweidler-McKay said that adults who have already had a transplant, or any age leukemia patient who is not eligible for other stem cell transplants due to blood counts or illness, may be available to use his new transplant method.

"These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. Most importantly, mouse models of human AML and ALL were sensitive to NK cell infusions," Zweidler-McKay said.

More information

The American Cancer Society has more about leukemia.



-- Kevin McKeever



SOURCE: University of Texas M. D. Anderson Cancer Center, news release, May 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
2. Data from Pooled Analyses Demonstrates Welchol, Combined with Metformin- or Sulfonylurea-Based Therapy, Significantly Lowers Blood Glucose in Adults with Type 2 Diabetes
3. Adding epratuzumab to standard therapy
4. Chemotherapy might help cancer vaccines work
5. The American College of Cardiology, American Heart Association and the Heart Rhythm Society Release Updated Cardiac Device-Based Therapy Guidelines
6. Drug therapy to bolster immune system cells found effective toward childhood cancer
7. Targeted therapy plus chemotherapy may pack 1-2 punch against melanoma
8. Blacks not receiving chemotherapy for rectal cancer, despite seeing cancer specialists
9. Drug therapy for PKU reverses heart damage
10. Therapy Yields Promise for Fatal Neurological Condition
11. Mayo Clinic study shows acupuncture and myofascial trigger therapy treat same pain areas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... PETALUMA, CA (PRWEB) , ... January 19, 2017 ... ... new Tranquility acoustic and privacy panel system. , The Tranquility privacy panel ... to a collaborative office environment. Tranquility panels help reduce noise and provide the ...
(Date:1/19/2017)... Ashland, VA (PRWEB) , ... January 19, 2017 , ... ... planning services to the eastern Virginia region, is inaugurating a charity event to honor ... community. , While on duty last year, Chad Phillip Dermyer and his fellow officers ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... Reproductive Endocrinologists at Reproductive Medicine Associates of Connecticut (RMACT) have earned “Top ... Cynthia Murdock and Dr. Shaun Williams have each been chosen by their peers ...
(Date:1/19/2017)... ... ... Sales Focus Inc. (SFI), a Maryland-based sales outsourcing company, announced today that ... 20 years SFI has been recognized as the world’s leader in Intelligent Sales Outsourcing ... US market. The new clients include: Panacea Pro, Campseekers, Contentmart, Stress Pal, Ariello, ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... lines and wrinkles. Few people know that popular cosmetic fillers can ... Buckley, who is medical director of the MilfordMD Cosmetic Dermatology Surgery & Laser ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 The global  pacemaker market  is expected to ... View Research, Inc. The heightening prevalence of cardiac conditions coupled with the availability ... globally. In addition, technological enhancements in these devices are supporting the expansion of ... ... Grand View Research Logo ...
(Date:1/19/2017)... , Jan. 18, 2017  ViewRay, Inc. ... world,s first and only clinical MRI-guided radiation therapy ... proceeds of approximately $26.1 million through a private ... Capital Management led the financing and was joined ... Advisors, LLC and Kearny Venture Partners, and an ...
(Date:1/19/2017)... 2017  Magnetic Insight Inc., leader in magnetic ... agreement with inviCRO LLC to develop intuitive image ... based on inviCRO,s VivoQuant™ visualization and post processing ... complete MPI solution package with the Momentum MPI ... imaging in vivo. MPI is a ...
Breaking Medicine Technology: