Navigation Links
New Therapy Kills Human Leukemia Cells in Mice
Date:5/16/2008

Technique expands natural killer cells in cord blood more than 30-fold

FRIDAY, May 16 (HealthDay News) A treatment that uses natural killer (NK) immune system cells from umbilical cord blood effectively destroys human leukemia cells in mice, researchers say.

The NK cells reduced by 60 percent to 85 percent human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells in test mice with aggressive human leukemias, according to the study.

The findings are to be presented at the May 16 American Society of Pediatric Hematology/Oncology annual conference, in Cincinnati.

Previous efforts like this one, which require the number of NK cells from a single cord blood to be expanded, resulted in ineffective NK cells. The new technique manages to increase NK cells in cord blood more than 30-fold while allowing the cells to retain their ability to target and kill acute leukemia cells.

"Cord blood is a promising source of natural killer cells, because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," investigator Dr. Patrick Zweidler-McKay, assistant professor of pediatrics from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center, said in a prepared statement.

Graft-versus-host disease is a common side effect of patients receiving stem cell transplants. It is fatal if not controlled.

The new process allows the NK cells to be transplanted to leukemia patients without the need for prior chemotherapy. Zweidler-McKay said that adults who have already had a transplant, or any age leukemia patient who is not eligible for other stem cell transplants due to blood counts or illness, may be available to use his new transplant method.

"These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. Most importantly, mouse models of human AML and ALL were sensitive to NK cell infusions," Zweidler-McKay said.

More information

The American Cancer Society has more about leukemia.



-- Kevin McKeever



SOURCE: University of Texas M. D. Anderson Cancer Center, news release, May 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
2. Data from Pooled Analyses Demonstrates Welchol, Combined with Metformin- or Sulfonylurea-Based Therapy, Significantly Lowers Blood Glucose in Adults with Type 2 Diabetes
3. Adding epratuzumab to standard therapy
4. Chemotherapy might help cancer vaccines work
5. The American College of Cardiology, American Heart Association and the Heart Rhythm Society Release Updated Cardiac Device-Based Therapy Guidelines
6. Drug therapy to bolster immune system cells found effective toward childhood cancer
7. Targeted therapy plus chemotherapy may pack 1-2 punch against melanoma
8. Blacks not receiving chemotherapy for rectal cancer, despite seeing cancer specialists
9. Drug therapy for PKU reverses heart damage
10. Therapy Yields Promise for Fatal Neurological Condition
11. Mayo Clinic study shows acupuncture and myofascial trigger therapy treat same pain areas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , ... April 28, 2016 , ... ... among the organization’s most successful events, attracting medical professionals from around the globe ... stimulating networking events. , Opening Ceremonies Sunday, April 17 included the introduction of ...
(Date:4/28/2016)... Maine (PRWEB) , ... April 28, 2016 , ... In ... death and principal determinant of childhood mortality. This is particularly true in underdeveloped parts ... lecture at the University of New England’s campus in Tangier, Morocco, will examine this ...
(Date:4/28/2016)... NY (PRWEB) , ... April 28, 2016 , ... ... Ingredient of the Year at VitaFoods 2016. , Nominated in the Healthy Ageing ... merit, efficacy, innovation, and safety. The Healthy Ageing division can include everything from ...
(Date:4/28/2016)... AZ (PRWEB) , ... April 28, 2016 , ... ... world leader in Aesthetic Surgery Education and Anzu®, developers of the AnzuMedical™ ... a Nationwide Plastic Surgery Collaborative Residency Network. The platform is scheduled to launch ...
(Date:4/28/2016)... ... April 28, 2016 , ... April, 28, 2016 ... Doc in Physical Medicine and Rehabilitation by Philadelphia Magazine. , Philadelphia Magazine’s annual ... randomly surveying physicians and medical leadership across the country. These select individuals nominate ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 New market research ... a report that provides an overview of the ... by identifying new targets and MOAs to produce ... discussed in this H1 2016 Osteoarthritis Pipeline report ... Inc., Abiogen Pharma S.p.A., Ablynx NV, Achelios Therapeutics, ...
(Date:4/27/2016)... Italy , April 27, 2016 ... linear accelerator (MR-linac) platform will be the focal point ... meeting of the European Society for Radiotherapy & Oncology, ... Elekta,s MR-linac integrates a state-of-the-art radiotherapy system and a ... physician to clearly see the patient,s anatomy in real ...
(Date:4/27/2016)... 27, 2016 Shire plc (LSE: SHP, ... , Chief Financial Officer, will present at the Deutsche Bank ... on Wednesday, May 04, 2016, 10:00 am EDT ... available on the Presentations and Webcasts section of Shire,s Investor ... webcast will be available on this same website for approximately ...
Breaking Medicine Technology: