Navigation Links
New Therapy Could Transform Arthritis Treatment
Date:11/13/2008

Modifying gene called Foxp3 may develop cells capable of suppressing immune response

THURSDAY, Nov. 13 (HealthDay News) -- New understanding about how to control autoimmune responses offers promise in efforts to develop treatments for rheumatoid arthritis (RA), British researchers say.

RA -- a painful, inflammatory form of arthritis -- occurs when the body's immune system attacks itself. A molecule called Foxp3 plays an important role in immune system regulation. People who lack or have mutated versions of the Foxp3 gene lack or have dysfunctional immune system regulation.

Scientists at the Medical Research Council's Laboratory of Molecular Biology in Cambridge genetically engineered a drug-inducible form of Foxp3, which enables them to switch developing immune cells into regulatory cells capable of suppressing immune response.

The study was published in the current issue of the journal PLoS Biology.

"We have generated a modified form of Foxp3 which can be introduced into immune cells using genetic engineering techniques and then activated by a simple injection. When administered to and activated in animal models of arthritis, the modified cells inhibit or even reverse the disease process," group leader Dr. Alexander Betz said in a PLoS Biology news release.

The researchers are now focusing on the molecular mechanisms involved in Foxp3 function and will then start working with human cells.

"First, we will develop a human Foxp3 factor and then assess its function in human arthritis models. To be viable as a therapeutic option, the regulatory cells must fulfill certain criteria: They must be tissue matched to the patient for compatibility; they must only block the targeted disease and not the whole body immune response; and they have to home correctly to their target tissue. Establishing these criteria will be the key focus of our research," Betz said.

"If Foxp3 functions as a key developmental switch in human immune cells, there is potential for a new avenue of therapy development that could transform arthritis treatment," he added.

More information

The Arthritis Foundation has more about rheumatoid arthritis.



-- Robert Preidt



SOURCE: PLoS Biology, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Proton therapy may reduce serious side effect of lung cancer treatment
2. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
3. Only Half of MS Patients Respond to Interferon Therapy
4. Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market
5. An ideal therapy for peptic ulcer disease
6. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies
7. Sale of Enzymatic Therapy, Inc. to Natures Way Holding Company Finalized
8. Ellex Announces Six-Month Results on Retina Regeneration Therapy
9. ESF workshop makes major advance in cancer radiotherapy
10. 5th Annual Global Conference on Stem Cell Therapy to be held Jan. 13-16, 2009 in NYC
11. New Study Demonstrates Cost Effectiveness of NeuroStar TMS Therapy(R) in the Treatment of Depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Therapy Could Transform Arthritis Treatment
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in ... 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced ... 2017. , The annual award competition recognizes editorial and design excellence across a range ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, single-family ... some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average ... extremely low property-tax rates, which contributes to the relatively lower cost of living ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... Sept. 25, 2017   Montrium , an ... solutions, today—from the IQPC Trial Master Files & ... NL)—announced that EastHORN Clinical Services has selected ... and TMF management. EastHORN, a leading European contract ... to increase transparency to enable greater collaboration with ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
Breaking Medicine Technology: