Navigation Links
New Therapy Could Transform Arthritis Treatment
Date:11/13/2008

Modifying gene called Foxp3 may develop cells capable of suppressing immune response

THURSDAY, Nov. 13 (HealthDay News) -- New understanding about how to control autoimmune responses offers promise in efforts to develop treatments for rheumatoid arthritis (RA), British researchers say.

RA -- a painful, inflammatory form of arthritis -- occurs when the body's immune system attacks itself. A molecule called Foxp3 plays an important role in immune system regulation. People who lack or have mutated versions of the Foxp3 gene lack or have dysfunctional immune system regulation.

Scientists at the Medical Research Council's Laboratory of Molecular Biology in Cambridge genetically engineered a drug-inducible form of Foxp3, which enables them to switch developing immune cells into regulatory cells capable of suppressing immune response.

The study was published in the current issue of the journal PLoS Biology.

"We have generated a modified form of Foxp3 which can be introduced into immune cells using genetic engineering techniques and then activated by a simple injection. When administered to and activated in animal models of arthritis, the modified cells inhibit or even reverse the disease process," group leader Dr. Alexander Betz said in a PLoS Biology news release.

The researchers are now focusing on the molecular mechanisms involved in Foxp3 function and will then start working with human cells.

"First, we will develop a human Foxp3 factor and then assess its function in human arthritis models. To be viable as a therapeutic option, the regulatory cells must fulfill certain criteria: They must be tissue matched to the patient for compatibility; they must only block the targeted disease and not the whole body immune response; and they have to home correctly to their target tissue. Establishing these criteria will be the key focus of our research," Betz said.

"If Foxp3 functions as a key developmental switch in human immune cells, there is potential for a new avenue of therapy development that could transform arthritis treatment," he added.

More information

The Arthritis Foundation has more about rheumatoid arthritis.



-- Robert Preidt



SOURCE: PLoS Biology, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Proton therapy may reduce serious side effect of lung cancer treatment
2. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
3. Only Half of MS Patients Respond to Interferon Therapy
4. Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market
5. An ideal therapy for peptic ulcer disease
6. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies
7. Sale of Enzymatic Therapy, Inc. to Natures Way Holding Company Finalized
8. Ellex Announces Six-Month Results on Retina Regeneration Therapy
9. ESF workshop makes major advance in cancer radiotherapy
10. 5th Annual Global Conference on Stem Cell Therapy to be held Jan. 13-16, 2009 in NYC
11. New Study Demonstrates Cost Effectiveness of NeuroStar TMS Therapy(R) in the Treatment of Depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Therapy Could Transform Arthritis Treatment
(Date:2/11/2016)... Oregon (PRWEB) , ... February 11, 2016 , ... ... campus participated in the American Osteopathic Association’s (AOA) Match Program Tuesday, February 9, ... Match Program places students into osteopathic graduate medical education positions across the country. ...
(Date:2/11/2016)... ... , ... The Journal of Pain Research has seen a significant ... data taken from the Scopus database (Elsevier B.V.) and is a measure of a ... journal over a three year period and also the importance of the journals where ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... has been gearing up for their simultaneous grand openings in March. All seven ... now that you’re probably wondering, is reversing diabetes possible? According to this 2011 ...
(Date:2/11/2016)... ... 2016 , ... Atlantic Information Services, Inc. (AIS) is pleased ... Study for Plans and Purchasers.” Executives from Intel Corp. and Providence Health & ... health benefits program Connected Care, will discuss the challenges they faced (and how ...
(Date:2/11/2016)... ... 2016 , ... PharmMD CEO Robert Yeager announced ... on contract negotiations, corporate strategy and healthcare data law. Additional responsibilities will include ... data breaches for the Part D Star Rating improvement and Medication Therapy Management ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 Wearable posture tracker, ALEX , has taken Kickstarter by ... and just seven days left to go, ALEX is said to be delivered to backers starting May ... ... ... Created by ...
(Date:2/11/2016)... Breast Cancer Therapeutics in Asia-Pacific Markets to 2021 ... breast cancer market will experience considerable expansion from $1.9 billion ... Annual Growth Rate (CAGR) of 8.5%. --> Breast ... that the Asia-Pacific (APAC) breast cancer ... to $3.4 billion by 2021, at a Compound Annual Growth ...
(Date:2/11/2016)... , Feb. 11, 2016 PLAD, Inc. (OTC ... 2016 with sales exceeding company targets, are adding key ... their trademark from the United States Patent and Trademark ... , Chief Executive Officer of PLAD, Inc.  In January, ... Pennsylvania with two new customers, Cumberland ...
Breaking Medicine Technology: