Navigation Links
New Therapy Could Transform Arthritis Treatment
Date:11/13/2008

Modifying gene called Foxp3 may develop cells capable of suppressing immune response

THURSDAY, Nov. 13 (HealthDay News) -- New understanding about how to control autoimmune responses offers promise in efforts to develop treatments for rheumatoid arthritis (RA), British researchers say.

RA -- a painful, inflammatory form of arthritis -- occurs when the body's immune system attacks itself. A molecule called Foxp3 plays an important role in immune system regulation. People who lack or have mutated versions of the Foxp3 gene lack or have dysfunctional immune system regulation.

Scientists at the Medical Research Council's Laboratory of Molecular Biology in Cambridge genetically engineered a drug-inducible form of Foxp3, which enables them to switch developing immune cells into regulatory cells capable of suppressing immune response.

The study was published in the current issue of the journal PLoS Biology.

"We have generated a modified form of Foxp3 which can be introduced into immune cells using genetic engineering techniques and then activated by a simple injection. When administered to and activated in animal models of arthritis, the modified cells inhibit or even reverse the disease process," group leader Dr. Alexander Betz said in a PLoS Biology news release.

The researchers are now focusing on the molecular mechanisms involved in Foxp3 function and will then start working with human cells.

"First, we will develop a human Foxp3 factor and then assess its function in human arthritis models. To be viable as a therapeutic option, the regulatory cells must fulfill certain criteria: They must be tissue matched to the patient for compatibility; they must only block the targeted disease and not the whole body immune response; and they have to home correctly to their target tissue. Establishing these criteria will be the key focus of our research," Betz said.

"If Foxp3 functions as a key developmental switch in human immune cells, there is potential for a new avenue of therapy development that could transform arthritis treatment," he added.

More information

The Arthritis Foundation has more about rheumatoid arthritis.



-- Robert Preidt



SOURCE: PLoS Biology, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Proton therapy may reduce serious side effect of lung cancer treatment
2. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
3. Only Half of MS Patients Respond to Interferon Therapy
4. Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market
5. An ideal therapy for peptic ulcer disease
6. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies
7. Sale of Enzymatic Therapy, Inc. to Natures Way Holding Company Finalized
8. Ellex Announces Six-Month Results on Retina Regeneration Therapy
9. ESF workshop makes major advance in cancer radiotherapy
10. 5th Annual Global Conference on Stem Cell Therapy to be held Jan. 13-16, 2009 in NYC
11. New Study Demonstrates Cost Effectiveness of NeuroStar TMS Therapy(R) in the Treatment of Depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Therapy Could Transform Arthritis Treatment
(Date:3/30/2017)... ... March 30, 2017 , ... This morning, more ... Trump expressing their support for an independent Vaccine Safety Commission. Five of the ... medical journalist, will hold a press conference at 9:00 AM Friday, March ...
(Date:3/29/2017)... ... March 29, 2017 , ... In the United States alone, up to 36% ... other types of metastatic brain tumors(3). Though most meningiomas are benign, metastatic brain tumors ... finding more effective treatment options, the San Diego Gamma Knife Center offers ...
(Date:3/29/2017)... ... March 30, 2017 , ... Grass pollen is the main cause of hay fever in ... The season for grass pollen runs from May to July each year; with the worst ... to do? HayMax™ allergen barrier balms ( http://www.haymax.us ) provide an effective defense against grass ...
(Date:3/29/2017)... (PRWEB) , ... March 30, 2017 , ... Sublime Naturals ... "Spice of Life" or "Wonder Spice", it has been used for thousands of years. ... the East," says Heshelow, author of " Turmeric: How to Use it For Your ...
(Date:3/29/2017)... Baton Rouge, Louisiana (PRWEB) , ... March 29, ... ... trademarked HeartBoost in three Hours at a Walgreens store in Mississippi. AngioGenesis Labs, ... campaign at Walgreens Stores in two southeastern states. Ingredients in HeartBoost, an over ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 29, 2017  Bodycad announced today that it ... 510(k) clearance for its Bodycad Unicompartmental Knee System, ... orthopaedic restoration. Bodycad is the first Canadian company ... implant system. Bodycad,s revolutionary Unicompartmental ... of the patient,s unique anatomical features and kinematics. ...
(Date:3/29/2017)... Mar. 29, 2017 Research and Markets has ... 2017-2021" report to their offering. ... The global energy-based aesthetic devices market to ... The report, Global Energy-Based Aesthetic Devices Market 2017-2021, has ... industry experts. The report covers the market landscape and its growth ...
(Date:3/29/2017)... -- Global intravenous (IV) iron and oral iron market is ... a CAGR of 5%. Iron drugs are ... anemia or other iron deficiencies. Oral iron supplements are recommended ... some cases, oral administrations are not capable of maintaining the ... comes into the picture. Global Intravenous (IV) Iron ...
Breaking Medicine Technology: