Navigation Links
New Therapy Could Transform Arthritis Treatment
Date:11/13/2008

Modifying gene called Foxp3 may develop cells capable of suppressing immune response

THURSDAY, Nov. 13 (HealthDay News) -- New understanding about how to control autoimmune responses offers promise in efforts to develop treatments for rheumatoid arthritis (RA), British researchers say.

RA -- a painful, inflammatory form of arthritis -- occurs when the body's immune system attacks itself. A molecule called Foxp3 plays an important role in immune system regulation. People who lack or have mutated versions of the Foxp3 gene lack or have dysfunctional immune system regulation.

Scientists at the Medical Research Council's Laboratory of Molecular Biology in Cambridge genetically engineered a drug-inducible form of Foxp3, which enables them to switch developing immune cells into regulatory cells capable of suppressing immune response.

The study was published in the current issue of the journal PLoS Biology.

"We have generated a modified form of Foxp3 which can be introduced into immune cells using genetic engineering techniques and then activated by a simple injection. When administered to and activated in animal models of arthritis, the modified cells inhibit or even reverse the disease process," group leader Dr. Alexander Betz said in a PLoS Biology news release.

The researchers are now focusing on the molecular mechanisms involved in Foxp3 function and will then start working with human cells.

"First, we will develop a human Foxp3 factor and then assess its function in human arthritis models. To be viable as a therapeutic option, the regulatory cells must fulfill certain criteria: They must be tissue matched to the patient for compatibility; they must only block the targeted disease and not the whole body immune response; and they have to home correctly to their target tissue. Establishing these criteria will be the key focus of our research," Betz said.

"If Foxp3 functions as a key developmental switch in human immune cells, there is potential for a new avenue of therapy development that could transform arthritis treatment," he added.

More information

The Arthritis Foundation has more about rheumatoid arthritis.



-- Robert Preidt



SOURCE: PLoS Biology, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Proton therapy may reduce serious side effect of lung cancer treatment
2. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
3. Only Half of MS Patients Respond to Interferon Therapy
4. Game Ready(TM) and ReGear Life Sciences(TM) Bring Innovative New Heat Therapy to Market
5. An ideal therapy for peptic ulcer disease
6. The Neuropathy Associations Scientific Research Grants Focus: Autoimmune and Chemotherapy-Induced Neuropathies
7. Sale of Enzymatic Therapy, Inc. to Natures Way Holding Company Finalized
8. Ellex Announces Six-Month Results on Retina Regeneration Therapy
9. ESF workshop makes major advance in cancer radiotherapy
10. 5th Annual Global Conference on Stem Cell Therapy to be held Jan. 13-16, 2009 in NYC
11. New Study Demonstrates Cost Effectiveness of NeuroStar TMS Therapy(R) in the Treatment of Depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Therapy Could Transform Arthritis Treatment
(Date:7/21/2017)... ... 21, 2017 , ... How physicians and athletic trainers assess ... researchers presenting their work at the American Orthopaedic Society for Sports Medicine’s ... the patterns of change in concussion symptom presentation, diagnostic tools used and length ...
(Date:7/20/2017)... Boston, MA (PRWEB) , ... July 20, 2017 ... ... aggressive form of blood and bone marrow cancer that progresses rapidly without treatment. ... often recommended to reduce the chance of reoccurrence and relapse. With such ...
(Date:7/20/2017)... ... July 20, 2017 , ... For individuals with extended hospital stays or who ... in such facilities are specially designed to accommodate patients with a wide range of ... inventor from Rochester, Ind., has invented the patent-pending PORTABLE ARM REST, a specially designed ...
(Date:7/20/2017)... ... July 20, 2017 , ... Doctors on Liens, the leading network of ... Chiropractic , directed by Dr. Russell Horine, DC to their exclusive list of medical ... Dr. Russell Horine serving as the clinic director and his son Dr. Lee Horine ...
(Date:7/20/2017)... , ... July 20, 2017 , ... ... **An FDAnews Webinar**, Aug. 9, 2017 — 1:30 p.m. – 3:00 p.m. ET, ... passing inspections and boosting quality. , It’s known as the “CY2016 Annual FDA ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... -- Endo International plc (NASDAQ: ENDP ) today ... manufacturing network, the Company will be ceasing operations and ... Huntsville, Alabama . The closure of the facilities ... to 18 months. The Huntsville ... products and these restructuring actions are intended to better ...
(Date:7/20/2017)... -- Prime Therapeutics LLC (Prime) released this statement from its Chief ... for Clinical and Economic Review,s (ICER) public meeting ... of abuse-deterrent formulations (ADF) of opioids. Prime was the sole ... "The ICER data ... use of abuse-deterrent formulations (ADF) in opioids in terms of ...
(Date:7/17/2017)... -- MedX Holdings, Inc., the manufacturer and global distributor of ... today announced the national roll out of its MedX ... standard for the treatment of low back injuries and ... How it works: MedX ... who prescribe the MedX Home Back Machine Program for ...
Breaking Medicine Technology: