Navigation Links
New Tests for Prostate Cancer Might Bring More Certainty
Date:6/2/2010

Gene-based screens could reduce unnecessary biopsies, worry, researchers say

WEDNESDAY, June 2 (HealthDay News) -- Two new tests promise to cut down on the number of biopsies now taken from men suspected of having prostate cancer, researchers report.

The tests -- still in the early stages of development -- might also offer better clues about which cancers require immediate treatment and which can be left for so-called "watchful waiting," researchers reported Tuesday at the American Urological Association's annual meeting, in San Francisco.

Both tests check for increased levels of genetic material -- one for the DNA of which genes are made, the other for the RNA that carries the messages from those genes. And both tests appear to add certainty to the suspicion of prostate cancer provided by the most widely used test for prostate cancer, the prostate-specific antigen (PSA) blood screen.

PSA testing is often used to screen men for prostate cancer. A high blood level reading of PSA is often followed by a biopsy -- tissue sample -- to detect cancer cells.

However, "only one of three [such patients] is likely to have a positive biopsy," noted Dr. Rakesh Singal, an associate professor of medicine at the University of Miami Miller School of Medicine, who presented one report at the meeting. "We wanted to come up with a test that tells us which patients are likely to have positive biopsies," to help spare men unnecessary procedures and worry, he said.

The test Singal described looks at blood levels of specific DNA. Prostate cancer can increase those levels, because malignant cells grow abnormally fast and cause the death of other cells, Singal explained.

The study included 252 men referred for prostate biopsies because of abnormal PSA test readings. Singal's team found that high levels of the target DNA were significantly associated with the presence of a cancer.

"What we think will probably happen in the future is that those men who have high PSA levels will [also] have this test," Singal said. "If the DNA levels are high they will have biopsies; if low, they can be observed periodically."

But for that to happen, the results of this study have to be confirmed, he said. "We hopefully will find funding for a study in a larger set of patients," Singal said.

The other test, described by Dr. E. David Crawford, a professor of urology at the University of Colorado, is targeted to elevated levels of PCA3 "messenger RNA" in urine. Again, elevated levels of this genetic material are associated with the presence of a tumor.

In the study, nearly 2,000 men with elevated PSA levels or abnormal results on a digital rectal examination (which measures prostate enlargement) also underwent PCA3 urine tests, followed by biopsies.

The PCA3 readings were significantly higher in those men whose biopsies turned out positive for cancer, the team found.

In addition, "PCA3 level reflects the aggressiveness of cancer," Crawford said, so that the test could be used to single out prostate cancers requiring immediate surgery or radiation treatment.

Further studies are needed to determine whether PCA3 testing could serve that purpose, he said. In the meantime, the immediate effect of the new data is to help develop "a new paradigm" for early detection of cancer, in which PCA3 testing would go along with PSA testing and digital rectal examinations, Crawford said.

That combination could reduce the need for biopsies, which are both expensive, cause discomfort and are associated with a risk of infection, he said.

According to Crawford, about a million biopsies are done in the United States each year because of suspected prostate cancer. "Anything you can do to cut down the large number of biopsies has innumerable advantages," he said.

More information

To learn more about prostate cancer, visit the U.S. National Cancer Institute.



SOURCES: Rakesh Singal, M.D., associate professor, medicine, University of Miami Miller School of Medicine; E. David Crawford, M.D., professor, urology, University of Colorado, Denver; June 1, 2010, presentations, American Urological Association annual meeting, San Francisco


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Tests Show Top Tuna Brands Have High Mercury Levels
2. Tests showing smokers their individual risk of future disease will help them quit, says paper
3. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
4. Stem Cells Turned Into AIDS Killers in Lab Tests
5. New Tests Confirm Wood Pallets Harbor Deadly Food Poisoning Bacteria
6. Targeted Testing Receives Favorable Reviews On PADDS, Begins Nationwide Research Study On The Target Tests of Executive Functioning-OV
7. Seattle-based PhenoPath Laboratories Retests Nearly 3,000 Breast Cancer Specimens from Quebec Breast Cancer Inquiry
8. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
9. In Tests, Implanted Monitor Detects Atrial Fibrillation
10. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
11. Tests to Measure Safety of Anti-Clotting Drugs of Limited Value
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... Learn to use popular ... or even in relationships. Course offered by Dr. Carol Francis at PVNET on ... limited seating and the many hands-on experiences. , Dr. Carol Francis shows ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... that its annual Solutions Series of webinars will start January 31 with a ... a number of current health and benefits topics, including employee engagement, pricing transparency, ...
(Date:1/24/2017)... ... January 24, 2017 , ... Bellus Medical, a leader in medical ... experts. In his new role Dr. Dobke will provide physician oversight for in-house clinical ... the Head of Plastic Surgery and Associate Professor of Surgery at UC San Diego ...
(Date:1/24/2017)... N.C. (PRWEB) , ... January 24, 2017 , ... ... Administration is the focus of a new report from the Frank Hawkins ... Business School. , Influential business leaders, academics and policy makers identified concrete solutions ...
(Date:1/24/2017)... ... January 24, 2017 , ... The results from the ... everyone and particularly good news for prostate cancer patients: incidents of cancer is down ... to the report the cancer death rate has dropped from its peak of 215.1 ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... 2017 Sherpa Clinical Packaging ( www.sherpaclinical.com ... is pleased to announce the appointment of Kevin Rosenthal as ... Sherpa team to lead Sherpa,s Operations group and ... excellence. Kevin is not new to ... He has extensive experience working for leading pharma ...
(Date:1/24/2017)... and PUNE, India , January 24, 2017 ... Allied Market Research, titled, "Acidity Regulators Market - Global ... for acidity regulators was valued at $4,456 million in 2015, and ... CAGR of 7.96% from 2016 to 2022. Asia-Pacific ... maintain its lead, followed by North America ...
(Date:1/24/2017)... , January 24, 2017 ... value of USD 3.8 billion by 2025, according to ... market growth can be attributed to the rising initiatives ... early diagnosis of micro calcifications in breast tissue. Some ... CDC, and Breast Cancer Organization are promoting the early ...
Breaking Medicine Technology: