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New Tests Might Better Predict Breast Cancer's Return
Date:12/6/2011

duct," explained Dr. Kerin Adelson, a medical oncologist specializing in breast cancer at Mount Sinai Medical Center in New York City. "In standard practice women who undergo lumpectomy for DCIS are treated with radiation to prevent local recurrence in the breast," she added.

However, "it has long been clear that some women are at higher risk for local recurrence than others," Adelson said. The new data "show that molecular profiling can be used to predict which cases of DCIS are at high risk for local recurrence and which are not. This may spare women with lower risk DCIS the need for breast radiation."

Another expert called the results "exciting," but had some reservations. "Although the authors state that this can be used to help eliminate radiation in some women, we may not yet be at that stage," said Dr. Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital in New York City. "The rate of recurrence was still 12 percent in the low-risk group and many clinicians and patients may not feel this is acceptable," she said.

Still, "even if we have not eliminated the need for radiation, the findings in this study are extremely significant because we will have more information to offer patients about their specific kind of DCIS," Bernik reasoned. "The findings also open the door to additional studies that will eventually allow us to avoid overtreatment and undertreatment of DCIS."

In the second study, researchers from Georgetown Lombardi Comprehensive Cancer Center and the University of Edinburgh zeroed in on molecular differences in tumors that can be used to predict whether or not women with hormone receptor-positive invasive breast cancer will experience recurrence of the disease and when. Hormone receptor-positive tumors are influenced by estrogen.

The researchers noted their findings could help explain why some women experience recurrence of this type of breast cancer up to 10 years or more following their original di
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