Navigation Links
New Test Predicts Risk of Post-Surgery Kidney Injury
Date:3/12/2008

Finding could lead to earlier treatments, better patient outcomes

WEDNESDAY, March 12 (HealthDay News) -- A new, simple lab test can identify patients at risk of developing acute kidney injury (AKI) after surgery up to three days sooner than the problem would otherwise be detected, a pilot study shows.

The finding could lead to earlier treatment and better patient outcomes, the researchers say.

The test measures a biomarker called neutrophil gelatinase-associated lipocalin (NGAL) in urine.

"Urine NGAL represents a powerful early predictive marker of AKI, preceding the increase in serum creatinine -- the current gold standard -- by several hours to days," study author Dr. Prasad Devarajan, of Cincinnati Children's Hospital Medical Center, said in a prepared statement.

"An early elevation in urine NGAL would trigger an immediate shift in clinical management, making caregivers aware of the high potential for development of clinical AKI," Devarajan said. Close monitoring and treatment may help prevent AKI from developing.

In this study, Devarajan and colleagues looked at 196 children who had cardiopulmonary bypass (CPB) surgery to repair congenital heart defects. This surgery is a major risk factor for AKI, a serious complication that can cause permanent loss of kidney function or death.

AKI occurred in 51 percent of the children, who were diagnosed with AKI based on increased levels of creatinine two to three days after surgery. The researchers found that urine NGAL levels began to increase within a few hours after these children had surgery. NGAL levels were 15 times higher than normal within two hours, and 25 times higher than normal within four hours.

Urine NGAL levels were highly accurate in predicting risk of AKI, said the researchers, who found that NGAL level at two hours identified 90 percent of children who later developed AKI. Urine NGAL also predicted the severity of AKI. Children with higher urine NGAL levels were more likely to require dialysis, more likely to die, and took longer to recover kidney function.

The study, which is published in the May issue of the Clinical Journal of the American Society of Nephrology, received funding from Abbott, which is developing the NGAL test.

More research on different groups of patients is needed to confirm the value of using NGAL as a biomarker to identify those at high risk for AKI, Devarajan said.

More information

The National Kidney Foundation has more about acute kidney injury.



-- Robert Preidt



SOURCE: American Society of Nephrology, news release, March 12, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. Work Time Predicts Sleep Time
3. Thomson Scientific Predicts Nobel Laureates
4. Segal Survey Predicts Declines in Trends for Fifth Consecutive Year
5. Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer
6. HER-2 status predicts success of chemotherapy in breast cancer treatment, study finds
7. New Data Suggests Progression of Disability at Two Years Predicts Multiple Sclerosis (MS) Disability Progression at Eight Years
8. Level of oxytocin in pregnant women predicts mother-child bond
9. MRI predicts liver fibrosis, study says
10. Quality of Life Predicts Lung Cancer Survival
11. Guardian of genome predicts treatment outcomes for childhood cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Test Predicts Risk of Post-Surgery Kidney Injury
(Date:1/24/2017)... , ... January 24, 2017 , ... ... provider of enterprise software products, today announced a strategic partnership with Lucidworks ... users to access and analyze their Fusion platform for building powerful enterprise search ...
(Date:1/24/2017)... Santa Rosa, California (PRWEB) , ... January 24, 2017 , ... ... named Cary McNamara as chief financial officer. , “Cary’s broad financial ... individual who possesses both the strategic planning and day-to-day financial operations skills we need ...
(Date:1/24/2017)... , ... January 24, 2017 , ... The Cruise ... Cruises as part of the line’s 4th Annual MSC True Partnerships’ Awards. ... North American travel partners for the year based on overall business growth in revenue ...
(Date:1/24/2017)... ... 24, 2017 , ... Twelve startups have been selected from ... Cup Entrepreneurship Competition. Chaired by Under Armour Founder and CEO Kevin Plank, the ... their businesses on February 6, 2017, at Under Armour’s global headquarters in Baltimore, ...
(Date:1/24/2017)... , ... January 24, 2017 , ... ... announced today that its annual Solutions Series of webinars will start January 31 ... leaders discussing a number of current health and benefits topics, including employee engagement, ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... LA JOLLA, Calif. , Jan. 24, 2017 /PRNewswire/ ... and new case studies using its Biomedical Intelligence® Cloud ... grow knowledge from a multitude of genomic, molecular and ... These updates were presented at a session hosted by ... Mountain View, CA. ...
(Date:1/24/2017)... 2017 Trifecta Clinical , a leading ... Rick Ward to Vice President of Commercial ... also announcing the promotion of Ericka Atkinson ... Rick joins Trifecta from Greenphire where he was ... business development positions within the healthcare industry throughout his ...
(Date:1/24/2017)... 2017 Research and Markets has announced the ... - Product, Material - Forecast to 2025" report to their ... The ... CAGR of around 5.4% over the next decade to reach approximately ... that the market is witnessing include 3D medical printing is expected ...
Breaking Medicine Technology: