Navigation Links
New Test Predicts Risk of Post-Surgery Kidney Injury

Finding could lead to earlier treatments, better patient outcomes

WEDNESDAY, March 12 (HealthDay News) -- A new, simple lab test can identify patients at risk of developing acute kidney injury (AKI) after surgery up to three days sooner than the problem would otherwise be detected, a pilot study shows.

The finding could lead to earlier treatment and better patient outcomes, the researchers say.

The test measures a biomarker called neutrophil gelatinase-associated lipocalin (NGAL) in urine.

"Urine NGAL represents a powerful early predictive marker of AKI, preceding the increase in serum creatinine -- the current gold standard -- by several hours to days," study author Dr. Prasad Devarajan, of Cincinnati Children's Hospital Medical Center, said in a prepared statement.

"An early elevation in urine NGAL would trigger an immediate shift in clinical management, making caregivers aware of the high potential for development of clinical AKI," Devarajan said. Close monitoring and treatment may help prevent AKI from developing.

In this study, Devarajan and colleagues looked at 196 children who had cardiopulmonary bypass (CPB) surgery to repair congenital heart defects. This surgery is a major risk factor for AKI, a serious complication that can cause permanent loss of kidney function or death.

AKI occurred in 51 percent of the children, who were diagnosed with AKI based on increased levels of creatinine two to three days after surgery. The researchers found that urine NGAL levels began to increase within a few hours after these children had surgery. NGAL levels were 15 times higher than normal within two hours, and 25 times higher than normal within four hours.

Urine NGAL levels were highly accurate in predicting risk of AKI, said the researchers, who found that NGAL level at two hours identified 90 percent of children who later developed AKI. Urine NGAL also predicted the severity of AKI. Children with higher urine NGAL levels were more likely to require dialysis, more likely to die, and took longer to recover kidney function.

The study, which is published in the May issue of the Clinical Journal of the American Society of Nephrology, received funding from Abbott, which is developing the NGAL test.

More research on different groups of patients is needed to confirm the value of using NGAL as a biomarker to identify those at high risk for AKI, Devarajan said.

More information

The National Kidney Foundation has more about acute kidney injury.

-- Robert Preidt

SOURCE: American Society of Nephrology, news release, March 12, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. Work Time Predicts Sleep Time
3. Thomson Scientific Predicts Nobel Laureates
4. Segal Survey Predicts Declines in Trends for Fifth Consecutive Year
5. Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer
6. HER-2 status predicts success of chemotherapy in breast cancer treatment, study finds
7. New Data Suggests Progression of Disability at Two Years Predicts Multiple Sclerosis (MS) Disability Progression at Eight Years
8. Level of oxytocin in pregnant women predicts mother-child bond
9. MRI predicts liver fibrosis, study says
10. Quality of Life Predicts Lung Cancer Survival
11. Guardian of genome predicts treatment outcomes for childhood cancer
Post Your Comments:
Related Image:
New Test Predicts Risk of Post-Surgery Kidney Injury
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... The successful ... emerging pharmaceutical company. Because it is so important to this key industry segment, Regis ... in your IND Filing” on December 4th at 11am EST. , Federal law does ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... of DataTrade Solutions Inc., a Healthcare IT consulting, development and support company. The ... and technical experience available within DataTrade to extend the services currently provided by ...
(Date:11/30/2015)... ... November 30, 2015 , ... GKhair & Tibolli team members and ... Beauty Show held on November 8th and 9th at the Puerto Rico Convention Center, ... artists, renowned beauticians and top of the line fashion journalists. The San Juan Beauty ...
(Date:11/30/2015)... ... 30, 2015 , ... Innovaacom, a leading provider of medical ... survey of educational needs for pharmacists worldwide. The poll of pharmacists in Europe, ... quality online and face-to-face education for pharmacists who are fast becoming the new ...
(Date:11/30/2015)... Burnsville MN (PRWEB) , ... November 30, 2015 ... ... addition of a new product dealer. Joining more than 30 HealthPostures’ dealers located ... its foot space and increase the number of corporate, industrial, manufacturing and government ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... -- Hanger, Inc. (NYSE: HGR ) (the "Company") today ... its previously announced consent solicitation (as amended and restated, ... amount 7⅛% Senior Notes due 2018 (the "Notes") to ... pursuant to the Consent Solicitation, (ii) the proposed increased ... date of the Consent Solicitation.    ...
(Date:11/30/2015)... Mexico Healthcare and Life Sciences Report 2015 ... . --> Pharmaboardroom releases its new 98-page Mexico ... America , a country of over 122 million people. ... 122 million people. --> It offers companies, investors, policymakers, ... insights into the second largest pharma and healthcare market in ...
(Date:11/29/2015)... Nov. 29, 2015   Royal Philips  (NYSE: PHG, ... solutions at the 2015 Radiological Society of North America ... McCormick Place in Chicago . Visitors ... the company,s broad portfolio of integrated Diagnostic Imaging, Clinical ... increase clinical performance, improve workflow and create a superior ...
Breaking Medicine Technology: