Navigation Links
New Test May Mean Faster Breast Cancer Treatment
Date:2/27/2009

Genetic analysis method can be used on all women with diagnosis, study says

FRIDAY, Feb. 27 (HealthDay News) -- A new genetic test that analyzes a set of 50 genes to identify four types of breast cancer could lead to quicker, more immediate treatment for patients, according to U.S. researchers who developed the test.

"Unlike a widely used genomic test that applies only to lymph-node-negative, estrogen-receptor-positive breast cancer, this new genomic test is broadly applicable for all women diagnosed with breast cancer," Dr. Matthew Ellis, of the Siteman Cancer Center at Washington University in St. Louis and Barnes-Jewish Hospital and a breast cancer specialist, said in a university news release.

Ellis and his colleagues analyzed the gene activity of more than 1,000 breast tumors and identified 50 genes that could be used to identify each of the four types of breast tumors -- luminal A, luminal B, HER2-enriched and basal-like. A genetic test called OncotypeDx, which is currently in wide use, doesn't identify all four tumor types, according to background information in the news release.

"Our test is the first to incorporate a molecular profile for the basal-like type breast cancers," Ellis said. "That's important because these breast cancers are arguably the most aggressive yet the most sensitive to chemotherapy. By identifying them, we can ensure they are treated adequately."

The new test also identifies what's often considered a fifth breast cancer type, known as normal-like. But the researchers discovered that, instead of being a fifth type of breast cancer, normal-like is an indicator that a breast tumor sample contains insufficient tumor cells to make a molecular diagnosis and that a new sample needs to be taken.

The researchers also said that the 50-gene test was highly accurate in predicting how 133 breast cancer patients would respond to chemotherapy. Luminal A was not sensitive to chemotherapy, which suggests that women with this good-prognosis type of breast cancer can forgo chemotherapy in favor of hormone-based therapy, they said. Among poor-prognosis types of breast cancer, they found that basal-like was the most sensitive to chemotherapy and luminal B the least sensitive.

The study was published online Feb. 9 in the Journal of Clinical Oncology.

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: Washington University in St. Louis, news release, February 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Antidepressants Offer Faster Relief
2. Health Insurance Premiums Rise 6.1 Percent in 2007, Less Rapidly Than in Recent Years But Still Faster Than Wages and Inflation
3. Toward a faster prenatal test for Down syndrome
4. Regulatory Affairs Associates Gets New Drugs Tested Faster, Wins 2007 Innovation Michigan Award
5. RACE: a statewide model of better, faster heart attack care
6. Redesigned Blue Shield of California Website Makes Finding a Doctor Online Easier and Faster
7. Mental Decline Faster in Brain-Injured Vietnam Vets
8. Cone-Beam CT faster, potentially more accurate than conventional mammography
9. Antidepressants that are more efficient and faster
10. Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments
11. Protein deficiency leads to faster fat burning in mice, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Test May Mean Faster Breast Cancer Treatment
(Date:2/20/2017)... ... 20, 2017 , ... Chuck E. Cheese’s® and Center for Autism and Related ... Chuck E. Cheese’s locations throughout New England, New York and New Jersey to provide ... the fun of visiting Chuck E. Cheese’s in a sensory-friendly environment. , After ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new Swain Department ... being led by Amelia Joseph, Ph.D. Joseph was engaged by the college as a ... department in early 2016. After a nation-wide search, she was selected to head the ...
(Date:2/19/2017)... ... February 19, 2017 , ... ... result in better care, and MEDfx and the Delaware Health Information Network (DHIN) ... , As the nation’s first state-wide health information exchange, DHIN stores and shares ...
(Date:2/18/2017)... Waltham, Massachusetts (PRWEB) , ... February 17, 2017 ... ... be the leading source of disruptive innovation in the industry, according to the ... Insights Reports are based on surveys of the NEJM Catalyst Insights Council, a ...
(Date:2/18/2017)... ... February 17, 2017 , ... Park Cities Pet Sitter President, Joette White, ... Pet Life Radio network. The episode, which was posted this week, features a ... factors led to Park Cities Pet Sitter’s being awarded the 2017 National Association of ...
Breaking Medicine News(10 mins):
(Date:2/19/2017)... Feb. 19, 2017   AC Group Inc. , ... ranking of vendors in the PMS/EHR healthcare marketplace, will ... system requirements to succeed in this ecosystem at HIMSS,17. ... together information obtained from over 200 ACOs, compared and ... and services companies that are providing different pieces of ...
(Date:2/19/2017)... , February 18, 2017 Marapharm ... to purchase a Medical Delivery Service with the specific ... transactions between qualified patients and caregivers. The delivery service ... located in the Coachella Valley, California ... Los Angeles area to the West, population ...
(Date:2/18/2017)... Feb. 17, 2017   Parker Waichman ... the rights of victims injured by medical devices, ... to call for better reporting. Congress required hospitals ... Safety concerns involving power morcellators and duodenoscopes prompted ... investigate how hospitals report injuries and deaths related ...
Breaking Medicine Technology: