Navigation Links
New Test May Mean Faster Breast Cancer Treatment
Date:2/27/2009

Genetic analysis method can be used on all women with diagnosis, study says

FRIDAY, Feb. 27 (HealthDay News) -- A new genetic test that analyzes a set of 50 genes to identify four types of breast cancer could lead to quicker, more immediate treatment for patients, according to U.S. researchers who developed the test.

"Unlike a widely used genomic test that applies only to lymph-node-negative, estrogen-receptor-positive breast cancer, this new genomic test is broadly applicable for all women diagnosed with breast cancer," Dr. Matthew Ellis, of the Siteman Cancer Center at Washington University in St. Louis and Barnes-Jewish Hospital and a breast cancer specialist, said in a university news release.

Ellis and his colleagues analyzed the gene activity of more than 1,000 breast tumors and identified 50 genes that could be used to identify each of the four types of breast tumors -- luminal A, luminal B, HER2-enriched and basal-like. A genetic test called OncotypeDx, which is currently in wide use, doesn't identify all four tumor types, according to background information in the news release.

"Our test is the first to incorporate a molecular profile for the basal-like type breast cancers," Ellis said. "That's important because these breast cancers are arguably the most aggressive yet the most sensitive to chemotherapy. By identifying them, we can ensure they are treated adequately."

The new test also identifies what's often considered a fifth breast cancer type, known as normal-like. But the researchers discovered that, instead of being a fifth type of breast cancer, normal-like is an indicator that a breast tumor sample contains insufficient tumor cells to make a molecular diagnosis and that a new sample needs to be taken.

The researchers also said that the 50-gene test was highly accurate in predicting how 133 breast cancer patients would respond to chemotherapy. Luminal A was not sensitive to chemotherapy, which suggests that women with this good-prognosis type of breast cancer can forgo chemotherapy in favor of hormone-based therapy, they said. Among poor-prognosis types of breast cancer, they found that basal-like was the most sensitive to chemotherapy and luminal B the least sensitive.

The study was published online Feb. 9 in the Journal of Clinical Oncology.

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: Washington University in St. Louis, news release, February 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Antidepressants Offer Faster Relief
2. Health Insurance Premiums Rise 6.1 Percent in 2007, Less Rapidly Than in Recent Years But Still Faster Than Wages and Inflation
3. Toward a faster prenatal test for Down syndrome
4. Regulatory Affairs Associates Gets New Drugs Tested Faster, Wins 2007 Innovation Michigan Award
5. RACE: a statewide model of better, faster heart attack care
6. Redesigned Blue Shield of California Website Makes Finding a Doctor Online Easier and Faster
7. Mental Decline Faster in Brain-Injured Vietnam Vets
8. Cone-Beam CT faster, potentially more accurate than conventional mammography
9. Antidepressants that are more efficient and faster
10. Varian Medical Systems Announces Symposia on RapidArc Technology for Faster, More Precise Radiotherapy Treatments
11. Protein deficiency leads to faster fat burning in mice, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Test May Mean Faster Breast Cancer Treatment
(Date:6/27/2016)... ... June 27, 2016 , ... ... health professionals, announced today its affiliation with Tennessee Counseling Association. This ... the network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
Breaking Medicine Technology: