Navigation Links
New Test Links Blood Protein to Heart Disease, Diabetes Risk
Date:12/7/2010

TUESDAY, Dec. 7 (HealthDay News) -- The presence of a certain biomarker in the blood is associated with structural heart disease and increased risk of death from all causes, a new study suggests.

It goes by the name of cardiac troponin T (cTnT) -- a heart-specific protein that serves as a biomarker for diagnosing heart attack.

In addition, elevated cTnT levels are associated with a number of chronic diseases such as coronary artery disease (CAD), heart failure, and chronic kidney disease, according to background information in the study.

"Recently, a highly sensitive assay (test) for cTnT has been developed that detects levels approximately 10-fold lower than those detectable with the standard assay," wrote Dr. James A. de Lemos, of the University of Texas Southwestern Medical Center in Dallas, and colleagues. "In patients with chronic heart failure and chronic CAD, circulating cTnT is detectable in almost all individuals with the highly sensitive assay, and higher levels correlate strongly with increased cardiovascular mortality."

In this study, the researchers used the highly sensitive test and the standard test to measure cTnT levels in 3,546 people, aged 30 to 65, in Dallas County. The prevalence of detectable cTnT among the participants was 25 percent using the highly sensitive test and 0.7 percent using the standard test.

The participants were then put into five categories based on their cTnT levels, and heart structure and function was measured with an MRI.

Detectable levels of cTnT were much more likely to be found in men than in women (37.1 percent vs. 12.9 percent), in blacks compared to Hispanics or whites, and in people aged 60 to 65 (57.6 percent) than in those aged 40 to 50 (14 percent).

The standard test failed to detect cTnT in two-thirds of participants with the highest cTnT levels. Increasing levels of cTnT were associated with higher rates of high blood pressure, diabetes, heart enlargement, heart failure, coronary artery disease, and cardiovascular disease. The rate of diabetes, for example, increased from 7.7 percent to 41 percent along with rising levels of cTnT; the rate of hypertension jumped from 27.2 percent to 70.9 percent as the biomarker levels went up.

After a median (midpoint) follow-up of 6.4 years, there were 151 deaths among the participants, including 62 cardiovascular disease deaths. Death from all causes increased from 1.9 percent to 28.4 percent for those with higher cTnT levels. After adjusting for a number of factors, the researchers concluded that cTnT levels were associated with all-causes mortality.

"Prior studies have described associations between increased troponin levels detected with standard assays and future risk for mortality. Here, we report that these associations extend to much lower troponin levels not detected with assays in current clinical use," the researchers wrote.

The researchers noted that further studies are needed to see whether the more sensitive test for cTnT levels could add value to traditional heart health risk factors.

The study appears in the Dec. 8 issue of the Journal of the American Medical Association.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart and vascular disease.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, Dec. 7, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Neuroscientists reveal new links that regulate brain electrical activity
2. MSU researcher links potentially deadly infection, frequent cow exposure
3. BATTLE links potential biomarkers to drugs for lung cancer
4. LifeLinks Revolutionizes Video Interpreting, Shows Spanish Interpreting in Added Dimension-VIDEO!
5. Study links microRNA to shut-down of DNA-repair genes
6. Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases
7. Experts call for urgent action to tackle strong links between impotence and heart disease
8. A Protein Links Alzheimers, Down Syndrome
9. U of M study definitively links indoor tanning to melanoma
10. New research at the University of Leicester links shoplifting to your personality
11. MSU researcher identifies links between hypertension, bipolar disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Test Links Blood Protein to Heart Disease, Diabetes Risk
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... law firm headquartered in Houston, is pleased to announce their expansion to the ... affordable housing experience, directors Alysse Hollis and Ronald Bell, and of counsels, John ...
(Date:7/20/2017)... ... ... Team Type 1 Foundation, a nonprofit organization pursuing a global mission of ... up with a Microsoft Corp. employee-led hackathon team for the 2017 Microsoft One Week ... Type 1’s mission overlaps seamlessly with Microsoft’s mission to empower every person and every ...
(Date:7/20/2017)... ... July 20, 2017 , ... Girl Up Campaign Director, Melissa ... legislation in support of providing girls access to education in refugee settings. In May, ... “Protecting Girls’ Access to Education in Vulnerable Settings Act.” Yesterday, companion legislation was ...
(Date:7/20/2017)... ... July 20, 2017 , ... TCGRx announced today ... existing adherence automation lines. The ATP® Mini and InspectRx® Mini are ... standard products, but at a size and price point that can help pharmacies ...
(Date:7/20/2017)... ... July 20, 2017 , ... With ... 2014, top travel insurance solution company VisitorsCoverage Inc. has launched TMQuotes, a new ... international travel insurance products online, under their own brand. The online marketplace bridges ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... , July 11, 2017  Bayer has awarded grants ... countries as part of its prestigious Bayer Hemophilia Awards Program ... of Philadelphia and Uniformed Services University ... are among the winners. Grant recipients were announced last night ... Hemostasis (ISTH) 2017 Congress, Berlin, Germany . ...
(Date:7/11/2017)... 2017  Sysmex America, Inc., a leading provider ... as well as middleware information systems technology, today ... quality assurance easier and more risk free than ... for the innovation that it delivers to the ... assurance processes to a new level with automated, ...
(Date:7/11/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... on the development of oral drug delivery systems, announced ... has agreed to schedule an End-of-Phase II meeting with ... its oral insulin capsule ORMD-0801 in the treatment of ... and secondary endpoints by indicating a statistically significant lowering ...
Breaking Medicine Technology: