Navigation Links
New Test Links Blood Protein to Heart Disease, Diabetes Risk
Date:12/7/2010

TUESDAY, Dec. 7 (HealthDay News) -- The presence of a certain biomarker in the blood is associated with structural heart disease and increased risk of death from all causes, a new study suggests.

It goes by the name of cardiac troponin T (cTnT) -- a heart-specific protein that serves as a biomarker for diagnosing heart attack.

In addition, elevated cTnT levels are associated with a number of chronic diseases such as coronary artery disease (CAD), heart failure, and chronic kidney disease, according to background information in the study.

"Recently, a highly sensitive assay (test) for cTnT has been developed that detects levels approximately 10-fold lower than those detectable with the standard assay," wrote Dr. James A. de Lemos, of the University of Texas Southwestern Medical Center in Dallas, and colleagues. "In patients with chronic heart failure and chronic CAD, circulating cTnT is detectable in almost all individuals with the highly sensitive assay, and higher levels correlate strongly with increased cardiovascular mortality."

In this study, the researchers used the highly sensitive test and the standard test to measure cTnT levels in 3,546 people, aged 30 to 65, in Dallas County. The prevalence of detectable cTnT among the participants was 25 percent using the highly sensitive test and 0.7 percent using the standard test.

The participants were then put into five categories based on their cTnT levels, and heart structure and function was measured with an MRI.

Detectable levels of cTnT were much more likely to be found in men than in women (37.1 percent vs. 12.9 percent), in blacks compared to Hispanics or whites, and in people aged 60 to 65 (57.6 percent) than in those aged 40 to 50 (14 percent).

The standard test failed to detect cTnT in two-thirds of participants with the highest cTnT levels. Increasing levels of cTnT were associated with higher rates of high blood pressure, diabetes, heart enlargement, heart failure, coronary artery disease, and cardiovascular disease. The rate of diabetes, for example, increased from 7.7 percent to 41 percent along with rising levels of cTnT; the rate of hypertension jumped from 27.2 percent to 70.9 percent as the biomarker levels went up.

After a median (midpoint) follow-up of 6.4 years, there were 151 deaths among the participants, including 62 cardiovascular disease deaths. Death from all causes increased from 1.9 percent to 28.4 percent for those with higher cTnT levels. After adjusting for a number of factors, the researchers concluded that cTnT levels were associated with all-causes mortality.

"Prior studies have described associations between increased troponin levels detected with standard assays and future risk for mortality. Here, we report that these associations extend to much lower troponin levels not detected with assays in current clinical use," the researchers wrote.

The researchers noted that further studies are needed to see whether the more sensitive test for cTnT levels could add value to traditional heart health risk factors.

The study appears in the Dec. 8 issue of the Journal of the American Medical Association.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart and vascular disease.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, Dec. 7, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Neuroscientists reveal new links that regulate brain electrical activity
2. MSU researcher links potentially deadly infection, frequent cow exposure
3. BATTLE links potential biomarkers to drugs for lung cancer
4. LifeLinks Revolutionizes Video Interpreting, Shows Spanish Interpreting in Added Dimension-VIDEO!
5. Study links microRNA to shut-down of DNA-repair genes
6. Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases
7. Experts call for urgent action to tackle strong links between impotence and heart disease
8. A Protein Links Alzheimers, Down Syndrome
9. U of M study definitively links indoor tanning to melanoma
10. New research at the University of Leicester links shoplifting to your personality
11. MSU researcher identifies links between hypertension, bipolar disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Test Links Blood Protein to Heart Disease, Diabetes Risk
(Date:3/29/2017)... , ... March 29, 2017 , ... Hamlin Dental Group, ... is now offering laser dental treatments. Dental lasers are safe and effective options, and ... patients’ options and can improve the overall quality of care. , Dr. Hamid Reza ...
(Date:3/29/2017)... ... March 29, 2017 , ... AvePoint , the Microsoft Cloud expert, is ... Richmond, Virginia, located at the Riverfront Plaza, 901 East Byrd Street. AvePoint is celebrating ... Ralph S. Northam and Mayor of Richmond Levar M. Stoney. , Founded in 2001, ...
(Date:3/28/2017)... ... ... For many women, getting birth control isn’t as easy as it should be. In fact, ... to a health care facility or a pharmacy within 60 minutes of where they live. ... for many who are faced with health or personal issues that leave them homebound. To ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... representatives in state legislatures and Congress to protect parental rights and civil liberties, ... and safety in America. , The demonstration coincides with a press conference taking ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... and services, is proud to announce it has joined the National Association for ... the interests of chronically ill, disabled, and dying Americans of all ages and ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... March 29, 2017 FinancialBuzz.com News Commentary  ... The U.S. could see ... a new report published by New Frontier Data, the legal cannabis ... pace of cannabis legalization in the United States ... considered to be a major factor that drives growth in this ...
(Date:3/28/2017)... , March 28, 2017  Las Vegas ophthalmology practice, ... XEN45 Gel Stent (Allergan, Dublin ), ... the eye, thereby reducing intraocular pressure in patients with ... globally are affected by glaucoma that can lead to ... and blindness, if left untreated. According to ...
(Date:3/28/2017)... 28, 2017 Summary ... Digital as a Key Component of Multichannel Marketing" ... marketing landscape in the digital age. While ... provide medical advancements, it has been much slower ... relying on traditional channels and methods. However, the ...
Breaking Medicine Technology: