Navigation Links
New Technology Shows Human Genome in 3-D
Date:10/8/2009

Technique lets researchers see how and where DNA fits into cells

THURSDAY, Oct. 8 (HealthDay News) -- The 3-D structure of the human genome has been deciphered by U.S. researchers, an achievement that improves understanding of genomic function and reveals how two meters of DNA can be packed into each human cell.

The scientists used a new technology called Hi-C, which enabled them to conduct genomewide analysis of the proximity of individual genes.

"We've long known that on a small scale, DNA is a double helix," co-first author Erez Lieberman-Aiden, a graduate student in the Harvard-MIT Division of Health Science and Technology and a researcher at Harvard's School of Engineering and Applied Sciences, said in a Harvard news release. "But if the double helix didn't fold further, the genome in each cell would be two meters long. Scientists have not really understood how the double helix folds to fit into the nucleus of a human cell, which is only about a hundredth of a millimeter in diameter. This new approach enabled us to probe exactly that question."

The scientists discovered that the human genome is organized into two separate compartments -- one that keeps active genes accessible and another that sequesters unused DNA.

"Cells cleverly separate the most active genes into their own special neighborhood, to make it easier for proteins and other regulators to reach them," senior author Job Dekker, an associate professor of biochemistry and molecular pharmacology at University of Massachusetts Medical School, said in the news release.

The researchers also found that the human genome uses fractal globule architecture to pack about three billion base pairs of DNA into each cell without any knots or tangles that could interfere with a cell's ability to read its own genome.

"Nature's devised a stunningly elegant solution to storing information -- a super-dense, knot-free structure," senior author Eric Lander, director of the Broad Institute, a professor of biology at MIT and a professor of systems biology at Harvard Medical School, stated in the news release.

The study appears in the Oct. 9 issue of Science.

More information

The U.S. National Human Genome Research Institute has more about genomics.



-- Robert Preidt



SOURCE: Harvard University, news release, Oct. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Versus Technology Provides Real-Time Patient Flow and Volume Management to Eastern Maine Medical Centers New Imaging Center
2. Swine Flu (H1N1) Virus Destroyed by Innovative Air Treatment Technology
3. High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
4. Terumo Heart, Inc.'s DuraHeart™ Left-Ventricular Assist System Featured at Future of Health Technology Summit
5. Hugh Chatham Adopts Star Trek Technology with the Use of Palm Identify to Prevent Medical ID Theft
6. Cyberonics Announces Epilepsy Technology Collaborations
7. MapleWorks' Video Application Development Technology Allows for High Level of Collaboration, Cooperation
8. California Cancer Specialists Medical Group, Inc. finds clinical benefit in RapidArc(TM) technology and executes strategic vendor agreement with Varian Medical Systems, Inc.
9. MediZine Named in Intellectual Property Lawsuit Filed by Marketing Technology Solutions
10. Innovative Medical Technology Companies From Around the World Selected to Present Profiles to Industry Leaders & Financiers at AdvaMed 2009
11. Ventus Medical Announces PROVENT(R) Sleep Apnea Therapy Recognized by The Wall Street Journal 2009 Technology Innovation Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is ... vendors and unique items from across the nation, this holiday-themed event will raise funds ... by the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... system that we intend to develop to enable prevention of a major side ... severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA ...
(Date:10/12/2017)... GRAND RAPIDS, Mich. (PRWEB) , ... October 12, ... ... OnSite Wellness, has been named one of Michigan’s 2017 Best and Brightest in ... Best and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... WASHINGTON , Sept. 28, 2017 Cohen ... to advance the use of wearable and home sensors ... brain disorders. Early Signal Foundation, a nonprofit organization focused ... populations, will provide an affordable analytical system to record ... ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a ... targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , ...
Breaking Medicine Technology: