Navigation Links
New Technology Shows Human Genome in 3-D
Date:10/8/2009

Technique lets researchers see how and where DNA fits into cells

THURSDAY, Oct. 8 (HealthDay News) -- The 3-D structure of the human genome has been deciphered by U.S. researchers, an achievement that improves understanding of genomic function and reveals how two meters of DNA can be packed into each human cell.

The scientists used a new technology called Hi-C, which enabled them to conduct genomewide analysis of the proximity of individual genes.

"We've long known that on a small scale, DNA is a double helix," co-first author Erez Lieberman-Aiden, a graduate student in the Harvard-MIT Division of Health Science and Technology and a researcher at Harvard's School of Engineering and Applied Sciences, said in a Harvard news release. "But if the double helix didn't fold further, the genome in each cell would be two meters long. Scientists have not really understood how the double helix folds to fit into the nucleus of a human cell, which is only about a hundredth of a millimeter in diameter. This new approach enabled us to probe exactly that question."

The scientists discovered that the human genome is organized into two separate compartments -- one that keeps active genes accessible and another that sequesters unused DNA.

"Cells cleverly separate the most active genes into their own special neighborhood, to make it easier for proteins and other regulators to reach them," senior author Job Dekker, an associate professor of biochemistry and molecular pharmacology at University of Massachusetts Medical School, said in the news release.

The researchers also found that the human genome uses fractal globule architecture to pack about three billion base pairs of DNA into each cell without any knots or tangles that could interfere with a cell's ability to read its own genome.

"Nature's devised a stunningly elegant solution to storing information -- a super-dense, knot-free structure," senior author Eric Lander, director of the Broad Institute, a professor of biology at MIT and a professor of systems biology at Harvard Medical School, stated in the news release.

The study appears in the Oct. 9 issue of Science.

More information

The U.S. National Human Genome Research Institute has more about genomics.



-- Robert Preidt



SOURCE: Harvard University, news release, Oct. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Versus Technology Provides Real-Time Patient Flow and Volume Management to Eastern Maine Medical Centers New Imaging Center
2. Swine Flu (H1N1) Virus Destroyed by Innovative Air Treatment Technology
3. High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
4. Terumo Heart, Inc.'s DuraHeart™ Left-Ventricular Assist System Featured at Future of Health Technology Summit
5. Hugh Chatham Adopts Star Trek Technology with the Use of Palm Identify to Prevent Medical ID Theft
6. Cyberonics Announces Epilepsy Technology Collaborations
7. MapleWorks' Video Application Development Technology Allows for High Level of Collaboration, Cooperation
8. California Cancer Specialists Medical Group, Inc. finds clinical benefit in RapidArc(TM) technology and executes strategic vendor agreement with Varian Medical Systems, Inc.
9. MediZine Named in Intellectual Property Lawsuit Filed by Marketing Technology Solutions
10. Innovative Medical Technology Companies From Around the World Selected to Present Profiles to Industry Leaders & Financiers at AdvaMed 2009
11. Ventus Medical Announces PROVENT(R) Sleep Apnea Therapy Recognized by The Wall Street Journal 2009 Technology Innovation Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today that ... Supplier Horizon Award . One of ... was recognized for its support of Premier members through ... clinical excellence, and commitment to lower costs. ... this recognition of our outstanding customer service from Premier," ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
(Date:6/23/2016)... The Biotechnology industry might still ... great opportunities to investors. Stock-Callers.com assesses the recent performances ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... your complimentary trade alerts at: http://stock-callers.com/registration ...
Breaking Medicine Technology: