Navigation Links
New Technique Transforms iPS Cells into Natural Tumor Killers
Date:6/1/2010

A technique for producing natural killer T (NKT) cells, known for their role in suppressing tumor growth, has been successfully demonstrated for the first time using induced pluripotent stem (iPS) cells. Developed by researchers at RIKEN, Japan’s flagship research institution, the technique opens the door to effective new cell-targeted treatments for cancer.

(PRWeb UK) June 1, 2010 -- A technique for producing natural killer T (NKT) cells, known for their role in suppressing tumor growth, has been successfully demonstrated for the first time using induced pluripotent stem (iPS) cells. Developed by researchers at RIKEN, Japan’s flagship research institution, the technique opens the door to effective new cell-targeted treatments for cancer.

Through their production of TH1 cytokines, NKT cells play an essential role in innate immune responses, protecting against tumors and virus-infected cells. Yet while clinical trials have shown that injection of the glycolipid ?-GalCer can effectively activate an NKT cell antitumor response, most cancer patients have very few NKT cells, which has prevented the wider application of this therapy.

Induced pluripotent stem (iPS) cells, “all-purpose” cells capable of differentiating into any type of cell, present a potential solution to this shortage of NKT cells, but with a catch: in lymphocytes, rearrangement of genes during differentiation drastically diminishes the effectiveness of conventional iPS cell generation techniques, resulting in only a small portion of cells with the desired antitumor function.

To overcome this problem, the research team used mature NKT cells that had already undergone gene rearrangement to derive their iPS cells. As reported in the July issue of the Journal of Clinical Investigation, these iPS cells enabled them to generate large numbers of NKT cells that secrete abundant IFN-?, a TH1 cytokine that activates antitumor functions. When tested using a mouse model, the cells successfully reproduced the effects of natural NKT cells and suppressed tumor growth, validating the approach and setting the stage for powerful clinical applications in cancer therapy.

For more information, please contact:

Dr. Hiroshi Watarai
Laboratory for Immune Regulation
RIKEN Research Center for Allergy and Immunology
Tel: +81-(0)45-503-7008 / Fax: +81-(0)45-503-7006

Dr. Haruhiko Koseki
Laboratory for Developmental Genetics
RIKEN Research Center for Allergy and Immunology
Tel: +81-(0)45-503-9689 / Fax: +81-(0)45-503-9688

Ms. Tomoko Ikawa (PI officer)
Global Relations Office
RIKEN
Tel: +81-(0)48-462-1225 / Fax: +81-(0)48-462-4715

###

Read the full story at http://www.prweb.com/releases/2010/06/prweb4079844.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Different tonsillectomy techniques may result in fewer complications
2. In infant heart surgery, newer technique yields better survival in first year of life
3. Novel RNA interference screening technique identifies possible path for malignant glioma treatment
4. Atlanta Marketing Expert Introduces State-of-the-Art Search Engine Marketing Techniques
5. New microneedle antimicrobial techniques may foster medical tech innovation
6. Technique Might Boost Womens Fertility
7. New technique permits development of enzyme tool kit
8. Simple reduction technique decreases radiation dose associated with CT scans of the head
9. CT technique eliminates the need for X-rays in trauma patients with possible spinal fractures
10. TCT for Surgeons course will highlight hybrid surgical and interventional techniques
11. A new endoscopic technique for gastrointestinal perforations: the over-the-scope-clip
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Technique Transforms iPS Cells into Natural Tumor Killers
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: