Navigation Links
New Technique Activates Brain Neurons to Move Paralyzed Limb
Date:10/15/2008

Experiment with monkeys could lead to new treatments for severely injured patients

WEDNESDAY, Oct. 15 (HealthDay News) -- In the latest effort to cause movement in paralyzed limbs, researchers have found a way to activate single neurons in the brain and use them to move a paralyzed wrist.

In experiments with monkeys, the University of Washington researchers used a brain-computer interface to tap into brain cells, teach them to bypass a paralyzed area, and stimulate arm muscles. This research could lead to treatment for spinal cord injury, stroke and other movement disorders, and better prosthetic devices.

"We were interested in developing a potential treatment for paralysis," lead researcher Chet Moritz, from the department of physiology and biophysics at the University of Washington in Seattle, said during a teleconference Tuesday.

The approach used by Moritz's group is different from other methods using brain cells to stimulate paralyzed muscles. In other brain cell research, scientists tried to harness brain cells that were related to real or imagined movements.

By contrast, Moritz and his colleagues found they could use biofeedback to retrain most neurons to stimulate muscles.

The report was published in the Oct. 15 online edition of Nature.

For the study, Moritz's team temporarily paralyzed a monkey's arm. Then, they rerouted motor control signals from the monkey's brain to its arm muscles. Basically, they created an artificial path that sent electrical signals from single neurons to the paralyzed muscles.

"We recorded individual neurons from the brain area called the motor cortex, and we routed those neurons through a computer and used the activity of those neurons to stimulate the paralyzed muscle," Moritz said.

The monkeys used this stimulation to play a video game that required them to extend and flex their wrist. It was a game that the animals had been taught to play before the experiment began, Moritz noted.

"Once he [the monkey] was paralyzed, the only way to move his wrist was to change the activity of individual neurons in his brain, which then controlled stimulation of his muscles," Moritz said.

The researchers found that two-thirds of the neurons they tested could be used to control muscle stimulation.

"We also found that monkeys could learn very rapidly to control newly isolated neurons in order to stimulate their muscles," Moritz said. "Even neurons that were unrelated to the movement of his wrist could be brought under control and co-opted for control of the wrist muscles."

Co-author Eberhard Fetz, also a professor in the department of physiology and biophysics at the University of Washington, said during the teleconference that future work will focus on extending the time this brain-muscle interface is maintained.

This method can include several muscles and eventually groups of muscles, Fetz said. "We are thinking in terms of not just stimulating single muscles, but stimulating sites in the spinal cord that could activate muscles in a coordinated fashion," he said. "This could eventually lead to brain control of coordinated movements."

The study shows that this technology is possible, but many obstacles remain, Moritz said. "Certainly, we are several years away, if not several decades away, from this being ready for a clinical application," he said.

Paul Sanberg, director of the University of South Florida Center of Excellence for Aging and Brain Repair in Tampa, thinks that the research is promising.

"If they could overcome some of the problems of having implants in the brain over a long period and miniaturize the apparatus, it may be possible to use this technology to regain muscle movement in people," Sanberg said. "The amount of movement could be unlimited," he added.

Sanberg noted that for someone to use this device to regain the ability to walk would require stimulating a group of muscles. "This may not be necessary to improve the quality of life of paralyzed patients," he said. "Having the ability to have better control of a wheelchair or being able to use a wrist to perform tasks might be enough."

More information

For more on paralysis, visit the U.S. National Library of Medicine.



SOURCES: Oct. 14, 2008, teleconference with: Chet Moritz, Ph.D., and Eberhard Fetz, Ph.D., professor, both department of physiology and biophysics, University of Washington, Seattle; Paul Sanberg, Ph.D., D.Sc., professor of neurosurgery, and director, University of South Florida Center of Excellence for Aging and Brain Repair, Tampa; Oct. 15, 2008, online edition, Nature


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Advanced Circulatory Systems Receives $1.5 Million From NIH for Study of Cardiac Arrest Resuscitation Techniques
2. 3 Michigan Counties Participating in NIH Study of Cardiac Arrest Resuscitation Techniques
3. Bio-imaging mass spectrometry techniques reveal molecular details about complex systems
4. 3-D MRI technique helps radiologists detect high-risk carotid disease
5. Surgical technique halts cell loss, Parkinsons researchers find
6. New Technique Removes Gallbladder Without External Incisions
7. Vertos Medical Inc. Presents Clinical Data of its MILD™ Procedure at the 5th Annual Innovative Techniques in Spine Surgery Conference in Los Cabos, Mexico
8. Weizmann Institute scientists new technique gets to the root of cancer
9. Corneal transplant technique shows promise in children
10. Researchers hone technique to KO pediatric brain tumors
11. New Technique Harvests Stem Cells at Earlier Stage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Technique Activates Brain Neurons to  Move Paralyzed Limb
(Date:12/2/2016)... ... December 02, 2016 , ... Center for Autism and ... of those affected by autism spectrum disorder (ASD) and other developmental disabilities. The group, ... will give parents and other caregivers the opportunity to share stories and advice, seek ...
(Date:12/2/2016)... ... 02, 2016 , ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover ... he was inspired to practice medicine at an early age by his father, who ... making diagnoses and prescribing medicine,” he states. “It is about building relationships with people; ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... inspirational interview of two ostomy patients, standing as living proof that attitude and ... from digestive diseases and issues that spike around the holidays. This campaign will ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... More than ... and while 84 percent of parents report speaking with their child about sex related ... sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its second ...
(Date:12/2/2016)... ... 2016 , ... CloudLIMS.com, a class-leading provider of Laboratory Management ... Lite helps biobanks, clinical, research and testing laboratories keep track of their biospecimens, ... is a faster and a more efficient product, allowing batch processing of data, ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... in the ECG Cables And ECG Leadwires Market owing to ... devices. On the other hand, the Asia-Pacific ... rate during the forecast period. The market players ... plc ( Ireland ), Koninklijke Philips N.V. ( ... ( China ), held major share of the ...
(Date:12/2/2016)... Quantum Radiology,s Mobile Breast Center (QR MBC) ... to women at the workplace, thereby maximizing convenience and ... Air Lines and SunTrust Bank, and community health groups ... wellness initiatives. "I think it,s a great ... to have a mammogram without taking a large amount ...
(Date:12/2/2016)... , Dec. 2, 2016  Eli Lilly and Company ... guidance for 2017 and provide updated financial guidance for ... conduct a conference call on that day with the ... financial guidance. The conference call will begin ... public can access a live webcast of the conference ...
Breaking Medicine Technology: