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New Taxotere(R) (docetaxel) Injection Concentrate Data to be Presented at the 30th Annual San Antonio Breast Cancer Symposium (SABCS)

rsday, December 13, 2007, 10:00 AM / Plenary lecture 1, Exhibit Hall D

Based on survival data previously reported for the BCIRG 006 study,

this presentation will describe how molecular subtypes of early stage

breast cancer could be used to identify appropriate Taxotere(R)-based

therapies, either with or without anthracyclines, for women with HER2

positive tumors.

-- Two other oral presentations will discuss studies involving

anthracycline regimens with or without Taxotere(R):

Abst 78: "Preliminary results of the UK Taxotere(R) as Adjuvant Chemotherapy (TACT) Trial." Ellis PA, et al; United Kingdom. Sunday, December 16, 2007, 10:45 AM / General session 7, Exhibit Hall D The UK TACT Trial, a large multicenter phase III randomized trial compared four cycles of sequential FEC* followed by four cycles of Taxotere(R) 100mg/m2 every three weeks to standard UK operable breast cancer adjuvant chemotherapy (FEC* or E-CMF*) for eight cycles.

*FEC : Fluorouracil 600mg/m squared, Epirubicin 60 mg/m2 , and Cyclophosphamide 600 mg/m2 q 3wk x 8

E-CMF: Epirubicin 100 mg/m2 q3wk x 4 followed by Cyclophosphamide100 mg/m2 PO d1-14 or 600 mg/m2 IV d1-8, Methotrexate 40 mg/m2, and Fluorouracil 600 mg/m2 q 4wk x 4

Abst 72: "Three-year follow-up of trastuzumab following adjuvant chemotherapy in node positive HER2-positive breast cancer patients: results of the PACS-04 trial." Spielmann M, et al.

Sunday, December 16, 2007, 9:15 AM / General session 7, Exhibit Hall D

Following the PACS-01 trial, the PACS-04 randomized, multicenter,

phase III trial is designed to evaluate concomitant Taxotere(R) and

epirubicin versus a standard French chemotherapy regimen (FEC 100*) in

the adjuvant treatment of node-positive early breast cancer, and the

sequential use or not of trastuzumab for HER2 positive patients.

*FEC100: Fluorouracil 500 mg

SOURCE sanofi-aventis
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