Navigation Links
New Target May Be Eyed in Kids' Brain Cancer
Date:12/7/2009

Scientists closer to understanding the development of deadly neuroectodermal tumors

MONDAY, Dec. 7 (HealthDay News) -- Scientists have identified oncogenes that play a role in a particularly aggressive type of childhood brain tumor.

Known as central nervous system primitive neuroectodermal tumors (CNS-PNETs), the discovery of these oncogenes may lead to improved diagnosis and treatment of the deadly condition.

"Lack of insight into the molecular pathogenesis of CNS-PNET is a major obstacle towards development of disease-specific models and treatments for these frequently fatal malignancies," noted senior study author Dr. Annie Huang, of the Hospital for Sick Children in Toronto.

She and colleagues from Asia, Europe and the United States conducted a high resolution genomic screen of CNS-PNET tumors and found that a DNA segment that contains a group of 54 microRNA (miRNA) genes was present in many copies in aggressive tumor cells.

The specific miRNAs from this C19MC group can stimulate growth and prevent development of normal human neural stem cells into more mature types of brain cells, the researchers said. They also found that the C19MC miRNA oncogenes can cause aggressive tumors by altering signaling pathways that regulate normal neural stem cell growth.

"Our findings highlight C19MC as an attractive candidate biomarker and therapeutic target for aggressive pediatric brain tumors and support an emerging theme that miRNAs are important determinants of tumor biology," Huang said. "Together with recent reports which implicate C19MC miRNAs in aggressive primary breast cancer, our findings suggest activation of the C19MC locus may generally define aggressive human tumors."

The study appears in the December issue of Cancer Cell.

More information

The Nemours Foundation has more about childhood brain tumors.



-- Robert Preidt



SOURCE: Cell Press, news release, Dec. 7, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. With White House Jobs Summit This Week KSBH Unveils New TV Ads Targeting Senators on Health Care
2. Alcohol companies target youths with magazine ads, new study shows
3. Targeted Breast Ultrasound Can Reduce Biopsies for Women Under Forty
4. Targeted breast ultrasound can reduce biopsies for women under 40
5. Targeted Testing Receives Favorable Reviews On PADDS, Begins Nationwide Research Study On The Target Tests of Executive Functioning-OV
6. Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers
7. First live targeting of tumors with RNA-based technology
8. Researchers identify proteins in lung cancer cells that may provide potential drug targets
9. Hard To Treat Diseases (HTDS) Exploration Of A 25 Billion Dollar Industry Regenerative Medicine and Stem Cell Bank Targeted Merger
10. Senate Votes to Proceed - 60 Plus Announces New 9 State TV Campaign Targeted at Senators to Protect Medicare
11. New cancer target for non-Hodgkins lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history ... The Brink” is the creation of published author, William Nowers. Captain Nowers and ... WWII veteran, he spent thirty years in the Navy. Following his career as ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/10/2017)... ORANGE COUNTY, Calif. , Oct. 10, 2017  NDS received ... Mobile  — a medical-grade battery-powered display stand specifically designed for ... aims to transform technology into a clinical solution to support the ... costs. Innovative Design ... NDS ZeroWire Mobile Wireless Solution ...
(Date:10/7/2017)... IRVING, Texas , Oct. 6, 2017   ... industry with more than $100 billion in purchasing power, ... industry news and information. The Newsroom is ... chain and industry trends, infographics, expert bios, news releases, ... Besides having access to a wealth of resources at ...
Breaking Medicine Technology: