Navigation Links
New Target May Be Eyed in Kids' Brain Cancer
Date:12/7/2009

Scientists closer to understanding the development of deadly neuroectodermal tumors

MONDAY, Dec. 7 (HealthDay News) -- Scientists have identified oncogenes that play a role in a particularly aggressive type of childhood brain tumor.

Known as central nervous system primitive neuroectodermal tumors (CNS-PNETs), the discovery of these oncogenes may lead to improved diagnosis and treatment of the deadly condition.

"Lack of insight into the molecular pathogenesis of CNS-PNET is a major obstacle towards development of disease-specific models and treatments for these frequently fatal malignancies," noted senior study author Dr. Annie Huang, of the Hospital for Sick Children in Toronto.

She and colleagues from Asia, Europe and the United States conducted a high resolution genomic screen of CNS-PNET tumors and found that a DNA segment that contains a group of 54 microRNA (miRNA) genes was present in many copies in aggressive tumor cells.

The specific miRNAs from this C19MC group can stimulate growth and prevent development of normal human neural stem cells into more mature types of brain cells, the researchers said. They also found that the C19MC miRNA oncogenes can cause aggressive tumors by altering signaling pathways that regulate normal neural stem cell growth.

"Our findings highlight C19MC as an attractive candidate biomarker and therapeutic target for aggressive pediatric brain tumors and support an emerging theme that miRNAs are important determinants of tumor biology," Huang said. "Together with recent reports which implicate C19MC miRNAs in aggressive primary breast cancer, our findings suggest activation of the C19MC locus may generally define aggressive human tumors."

The study appears in the December issue of Cancer Cell.

More information

The Nemours Foundation has more about childhood brain tumors.



-- Robert Preidt



SOURCE: Cell Press, news release, Dec. 7, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. With White House Jobs Summit This Week KSBH Unveils New TV Ads Targeting Senators on Health Care
2. Alcohol companies target youths with magazine ads, new study shows
3. Targeted Breast Ultrasound Can Reduce Biopsies for Women Under Forty
4. Targeted breast ultrasound can reduce biopsies for women under 40
5. Targeted Testing Receives Favorable Reviews On PADDS, Begins Nationwide Research Study On The Target Tests of Executive Functioning-OV
6. Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers
7. First live targeting of tumors with RNA-based technology
8. Researchers identify proteins in lung cancer cells that may provide potential drug targets
9. Hard To Treat Diseases (HTDS) Exploration Of A 25 Billion Dollar Industry Regenerative Medicine and Stem Cell Bank Targeted Merger
10. Senate Votes to Proceed - 60 Plus Announces New 9 State TV Campaign Targeted at Senators to Protect Medicare
11. New cancer target for non-Hodgkins lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... People across ... in Genome magazine’s Code Talker Award, an essay contest in which patients and their ... award to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative ... has initiated cultivation and processing operations at its production facility, and opened its ... Puradigm is the manufacturer of a complete system of proactive air and surface ...
(Date:6/24/2016)... ... 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The ... members that have been wounded in battle and their families. Venture Construction Group is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: