Navigation Links
New Target May Be Eyed in Kids' Brain Cancer
Date:12/7/2009

Scientists closer to understanding the development of deadly neuroectodermal tumors

MONDAY, Dec. 7 (HealthDay News) -- Scientists have identified oncogenes that play a role in a particularly aggressive type of childhood brain tumor.

Known as central nervous system primitive neuroectodermal tumors (CNS-PNETs), the discovery of these oncogenes may lead to improved diagnosis and treatment of the deadly condition.

"Lack of insight into the molecular pathogenesis of CNS-PNET is a major obstacle towards development of disease-specific models and treatments for these frequently fatal malignancies," noted senior study author Dr. Annie Huang, of the Hospital for Sick Children in Toronto.

She and colleagues from Asia, Europe and the United States conducted a high resolution genomic screen of CNS-PNET tumors and found that a DNA segment that contains a group of 54 microRNA (miRNA) genes was present in many copies in aggressive tumor cells.

The specific miRNAs from this C19MC group can stimulate growth and prevent development of normal human neural stem cells into more mature types of brain cells, the researchers said. They also found that the C19MC miRNA oncogenes can cause aggressive tumors by altering signaling pathways that regulate normal neural stem cell growth.

"Our findings highlight C19MC as an attractive candidate biomarker and therapeutic target for aggressive pediatric brain tumors and support an emerging theme that miRNAs are important determinants of tumor biology," Huang said. "Together with recent reports which implicate C19MC miRNAs in aggressive primary breast cancer, our findings suggest activation of the C19MC locus may generally define aggressive human tumors."

The study appears in the December issue of Cancer Cell.

More information

The Nemours Foundation has more about childhood brain tumors.



-- Robert Preidt



SOURCE: Cell Press, news release, Dec. 7, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. With White House Jobs Summit This Week KSBH Unveils New TV Ads Targeting Senators on Health Care
2. Alcohol companies target youths with magazine ads, new study shows
3. Targeted Breast Ultrasound Can Reduce Biopsies for Women Under Forty
4. Targeted breast ultrasound can reduce biopsies for women under 40
5. Targeted Testing Receives Favorable Reviews On PADDS, Begins Nationwide Research Study On The Target Tests of Executive Functioning-OV
6. Reportlinker Adds The Future of Senior Nutrition: Key Ingredients, Strategic Issues and Targeted Opportunities for Older Consumers
7. First live targeting of tumors with RNA-based technology
8. Researchers identify proteins in lung cancer cells that may provide potential drug targets
9. Hard To Treat Diseases (HTDS) Exploration Of A 25 Billion Dollar Industry Regenerative Medicine and Stem Cell Bank Targeted Merger
10. Senate Votes to Proceed - 60 Plus Announces New 9 State TV Campaign Targeted at Senators to Protect Medicare
11. New cancer target for non-Hodgkins lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... A ... Ohio Safety Congress and Expo event March 9-11, 2016. Hosted by Ohio's Bureau ... Center. , As the longest running and largest worker's compensation event in ...
(Date:2/10/2016)... MD (PRWEB) , ... February 10, 2016 , ... ... to make Everseat digital self-scheduling readily available to physicians. The integration ... patients can find and select appointments via Everseat’s free mobile app. , The ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions - Time: 7:00pm ... 7:00pm – 10:00pm | Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org , ...
(Date:2/10/2016)... ... 10, 2016 , ... Workrite Ergonomics, who is celebrating their 25th year of ... to being an internationally recognized leader in their industry. , "We are very proud ... President of Workrite. “Workrite recognized the importance of good ergonomics before most of ...
(Date:2/10/2016)... ... February 10, 2016 , ... Anxiety of older Americans over ... of Medicare Part D a decade ago, according to The Senior Citizens League ... on how they are coping with rapidly rising costs. “The implications are chilling, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)...  Bluestar Silicones will promote its Silbione® Biomedical ... implant applications and announce certification of its clean ... West Conference (Booth #1759), February 9-10, at the ... --> Available in 01 through 70 ... physical properties enabling our customers to optimize their ...
(Date:2/8/2016)... -- Alzheimer Diagnostic Tests - Medical Devices Pipeline ... sector report , "Alzheimer Diagnostic Tests - Medical ... Alzheimer Diagnostic Tests currently in pipeline stage. ... products with comparative analysis of the products at ... players involved in the pipeline product development. It ...
(Date:2/8/2016)... Devices - Medical Devices Pipeline Assessment, 2015 Summary ... Medical Devices Pipeline Assessment, 2015" provides an overview of ... This report is prepared using data sourced from in-house ... industry experts. *Note: Certain sections in the report ... and relevance of data in relation to the equipment ...
Breaking Medicine Technology: