Navigation Links
New TGen, Virginia G. Piper Cancer Center study targets non-small cell lung cancer
Date:8/29/2012

SCOTTSDALE, Ariz. August 29, 2012 A Phase I/II, multi-center trial designed to test the safety and preliminary efficacy of a first in class cancer treatment opened worldwide today at the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen). PR610 is designed to become activated in tissues with low levels of oxygen, which is characteristic of many cancers. This "targeted" approach should deliver more active drug to cancer tissue and less active drug to normal tissue.

The two-part trial, sponsored by the drug's manufacturer, Proacta Inc., will first determine acceptable dose levels of PR610 in patients with various types of advanced cancer. After determining acceptable dose levels, the study will evaluate the safety and efficacy of PR610 when given to patients with non-small cell lung cancer whose tumors contain a certain genetic mutation. Other goals of the study are to measure levels of PR610 in the blood.

"PR610 is a promising and innovative compound that merges delivery of a drug to the cancerous, oxygen depleted tissue and it also targets the communication functions that govern the growth and behavior that drive certain cancers," said Dr. Glen Weiss, Clinical Associate Professor at TGen and Director of Thoracic Oncology at Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare.

Research has shown that some cancer tissue has lower levels of oxygen than normal tissue. This lower level of oxygen appears to make the cancer tissue more resistant to radiation and chemotherapy, which allows the cancer to become more aggressive and spread. PR610 is designed to become active in cancer tissue with low levels of oxygen.

"Proacta is very excited to be working with Virginia G. Piper Cancer Center Clinical Trials and TGen on this important study. We purposely limited participation in this study to
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Healthy Back Store Confirms Closure of East Tyson’s Virginia Location
2. Could a cancer drug potentially prevent learning disabilities in some kids?
3. Aspirin may help men with prostate cancer live longer, study suggests
4. Race May Affect Quality of Prostate Cancer Surgical Care
5. Mayo study: Exercise can help cancer patients, but few oncologists suggest it
6. Exploring exercise benefits for breast cancer patients
7. Not all lung cancer patients who could benefit from crizotinib are identified by FDA-approved test
8. Breast Cancer Drug Might Help Men on Prostate Cancer Therapy
9. Reducing the side effects of treatment for prostate cancer
10. Accuracy of narrow band imaging with colonoscopy allows for distal non-cancerous polyps to be left in place
11. Daily Aspirin May Help Fight Prostate Cancer, But Not Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... (PRWEB) June 03, 2015 Visual ... Analytics solutions, today announced the launch of the ... (DSX) for SAP® BusinessObjects™ Design Studio. The Design ... visualization capabilities and advanced functionalities into their dashboarding ... DSX suite, Visual BI is adding key components ...
(Date:6/3/2015)... PA (PRWEB) June 03, 2015 Sitting ... can cause discomfort in the back, neck, shoulders and/or ... other musculoskeletal injuries. In addition, recent research links sitting ... number of chronic diseases. Fortunately, three inventors from Oakville, ... sit at a desk. , They have developed a ...
(Date:6/3/2015)... Fourroux Prosthetics, located at 6630 McGinnis Ferry ... grand opening with a ribbon cutting ceremony on Wednesday, ... its kind in the area, Fourroux Prosthetics will provide ... through use of patented advanced prosthetics CAD/CAM technology. ... Prosthetics, states, “Our goal has always been to provide ...
(Date:6/3/2015)... (PRWEB) June 03, 2015 First ... freestanding emergency rooms in the United States, announced that ... facility in late June. , “I am pleased ... Texas with a new facility in the San Antonio ... of First Choice Emergency Room. , First Choice ...
(Date:6/3/2015)... Washington, DC (PRWEB) June 03, 2015 ... podiatrist Dr. Casey Friske ( Clarksville ... Podiatrist Scholarship from the Symposium of Advanced Wound Care ... by APMA President-Elect Dr. Dan Davis. The Conference ... Henry B. Gonzalez Convention Center in San Antonio, TX. ...
Breaking Medicine News(10 mins):Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 2Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 3Health News:Adjustable Height Tabletop Unit Invented by Three InventHelp® Clients (TOR-9278) 2Health News:Fourroux Prosthetics Atlanta to Have Grand Opening Gala & Ribbon Cutting Ceremony 2Health News:First Choice Emergency Room to Open New Facility in San Antonio, Texas 2Health News:Foot and Ankle Specialists of the Mid-Atlantic, LLC Receives Award at the Spring 2015 Symposium of Advanced Wound Care Conference 2
... -- The discovery of a gene pattern that distinguishes highly ... may help improve treatment of bone cancer in children, according ... species that develops bone cancer spontaneously with any frequency. Dogs ... human and dog forms of bone cancer are very similar, ...
... News) -- Youth sports programs need to have guidelines ... updated policy statement from the American Academy of Pediatrics. ... in outdoor sports and activities in a wide range ... situations that are potentially dangerous," Dr. Stephen G. Rice, ...
... new source for sexual problems among middle-aged and older ... men,s closest friends. A study published Monday, August ... Chicago and Cornell University has found a connection between ... men and their partners. They describe the situation as ...
... PHILADELPHIA In the latest issue of Nature ... the University of Pennsylvania clarify the role of two ... well-known protein called Notch passes off much of its ... T cells are required for many aspects of immunity, ...
... , SUNDAY, Aug. 7 (HealthDay News) -- Be ... of Michigan Health System,s Trauma Burn Center, which has treated ... kinds of injuries are avoidable and the painful consequences often ... in a news release from the trauma center. Most ...
... RIVERSIDE, Calif. ( www.ucr.edu ) -- A professor at ... has received a $100,000 grant to develop a new ... Dimitrios "Dimitri" Morikis, a professor of bioengineering, and ... Study of Macular Degeneration at the University of California, ...
Cached Medicine News:Health News:Study of Bone Cancer in Dogs May Improve Treatment in Kids 2Health News:Kids Can Safely Play Sports in Hot Weather: Experts 2Health News:When a man's partner is too close to his friends, his sex life may suffer 2Health News:When a man's partner is too close to his friends, his sex life may suffer 3Health News:Penn researchers describe key molecule that keeps immune cell development on track 2Health News:Professor fights disease that destroys vision 2
(Date:6/3/2015)... AND PITTSBURGH , June 3, 2015 /PRNewswire/ ... pharmaceutical company, today announced that the Company will present at ... Tuesday June 9, 2015. The presentation is scheduled to begin ... Interested parties can access a live webcast of the ... http://mylan.com/investors .   Mylan is a global ...
(Date:6/3/2015)...  NxStage Medical, Inc. (Nasdaq: NXTM ), a ... announced data that home hemodialysis can save ... water annually by transitioning just 20 percent of ... the NxStage® System One™.  Industry data shows conventional ... per patient per week, whereas home hemodialysis with ...
(Date:6/3/2015)... Genoa has received final approval ... organizations with proven track records for excellent service to ... for outstanding customer service, flexibility and delivering true value ... is the leading provider of pharmacy services dedicated ... managing the cost and quality of their care. The ...
Breaking Medicine Technology:Home Hemodialysis With NxStage System One Can Save California 221 Million Gallons of Water Annually 2Genoa, a QoL Healthcare Company Acquires Northeast Pharmaceuticals, Inc. 2
... RIDGEFIELD, Conn., Oct. 24, 2011 Apelon, ... data interoperability solutions, today announced the availability ... solution. TermManager, a code set management and ... interoperability initiatives by enabling widespread access to ...
... Codexis, Inc. (Nasdaq: CDXS ) ... Codex® Screening Kits are in use or evaluation ... worldwide.  The announcement was made at CPhI  Worldwide, ... week.   Codex® Screening Kits were ...
Cached Medicine Technology:Apelon Announces Availability of New TermManager® Software 250 Pharma Companies Worldwide Now Use Codexis In Process Development 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: