Navigation Links
New TGen, Virginia G. Piper Cancer Center study targets non-small cell lung cancer
Date:8/29/2012

SCOTTSDALE, Ariz. August 29, 2012 A Phase I/II, multi-center trial designed to test the safety and preliminary efficacy of a first in class cancer treatment opened worldwide today at the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen). PR610 is designed to become activated in tissues with low levels of oxygen, which is characteristic of many cancers. This "targeted" approach should deliver more active drug to cancer tissue and less active drug to normal tissue.

The two-part trial, sponsored by the drug's manufacturer, Proacta Inc., will first determine acceptable dose levels of PR610 in patients with various types of advanced cancer. After determining acceptable dose levels, the study will evaluate the safety and efficacy of PR610 when given to patients with non-small cell lung cancer whose tumors contain a certain genetic mutation. Other goals of the study are to measure levels of PR610 in the blood.

"PR610 is a promising and innovative compound that merges delivery of a drug to the cancerous, oxygen depleted tissue and it also targets the communication functions that govern the growth and behavior that drive certain cancers," said Dr. Glen Weiss, Clinical Associate Professor at TGen and Director of Thoracic Oncology at Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare.

Research has shown that some cancer tissue has lower levels of oxygen than normal tissue. This lower level of oxygen appears to make the cancer tissue more resistant to radiation and chemotherapy, which allows the cancer to become more aggressive and spread. PR610 is designed to become active in cancer tissue with low levels of oxygen.

"Proacta is very excited to be working with Virginia G. Piper Cancer Center Clinical Trials and TGen on this important study. We purposely limited participation in this study to
'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Healthy Back Store Confirms Closure of East Tyson’s Virginia Location
2. Could a cancer drug potentially prevent learning disabilities in some kids?
3. Aspirin may help men with prostate cancer live longer, study suggests
4. Race May Affect Quality of Prostate Cancer Surgical Care
5. Mayo study: Exercise can help cancer patients, but few oncologists suggest it
6. Exploring exercise benefits for breast cancer patients
7. Not all lung cancer patients who could benefit from crizotinib are identified by FDA-approved test
8. Breast Cancer Drug Might Help Men on Prostate Cancer Therapy
9. Reducing the side effects of treatment for prostate cancer
10. Accuracy of narrow band imaging with colonoscopy allows for distal non-cancerous polyps to be left in place
11. Daily Aspirin May Help Fight Prostate Cancer, But Not Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... (PRWEB) September 02, 2014 Anti-aging ... products and services such as anti-wrinkle treatments and ... based treatments, and breast augmentation becoming much sought ... by U.S.-based market intelligence firm Transparency Market Research, ... products will grow to USD 191.7 billion by ...
(Date:9/2/2014)... CITY, GA (PRWEB) September 02, 2014 Last ... whole new level with the launch of a luxurious line ... to announce that the SEA ISLAND COTTON Socks are joining ... compression level, giving more people the comfort of natural cotton ... COTTON Socks, they are surprised to find socks as soft ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Alliance Strategies ... and multi-channel email marketing is pleased to announce it ... Firearms & Freedom as well as ... represent more than one million concerned Americans who can ... , “We are honored to continue providing our ...
(Date:9/2/2014)... What happens when you are hospitalized, but your ... arrive at the office for follow-up care, but ... about your hospital stay? Missing or incomplete ... (PCPs) can contribute to poor experiences and lead ... study shows that implementing guidelines can improve hospitals, ...
(Date:9/2/2014)... health risks, including heart disease and diabetes, but University ... mitigate one often-overlooked risk: not buckling up in the ... Jacobson, a professor of computer science and of mathematics, ... a decrease in seatbelt usage. However, these effects can ... "Primary seatbelt laws lead to increased use of seatbelts," ...
Breaking Medicine News(10 mins):Health News:Global Anti-aging Market Research Report 2018 by Transparency Market Research 2Health News:Global Anti-aging Market Research Report 2018 by Transparency Market Research 3Health News:SIGVARIS’ Luxury Line of Compression Socks, SEA ISLAND COTTON, Now Available in Stronger Compression Level 2Health News:ASG Continues to Bring New Lists to Market 2Health News:ASG Continues to Bring New Lists to Market 3Health News:Can data motivate hospital leaders to improve care transitions? 2Health News:Seatbelt laws encourage obese drivers to buckle up 2
... bit relaxed now. Genosis Inc, a US firm, has developed ... test has his and hers components a screening test ... the concentration of motile sperm, and a test for women ... ,The availability of the two-in-one test helps drive ...
... Depressed? Consider marriage as an option please, a pair of ... happier you could be after marriage . And never mind ... to benefit, claim Adrianne Frech, a sociology graduate student at ... ,They looked at a sample of 3,066 men and women ...
... WASHINGTON, D.C. A first-of-its-kind study presented at the 54th ... molecular imaging and nuclear medicine professionals , declares that ... tumor patients' response to treatment is a powerful predictor ... to the possibility that brain tumor patients may live ...
... of Preferred Provider Organizations (AAPPO) is launching a new ... care to those patients diagnosed with diabetes as ... An industry leader, AAPPO today kicked off its new ... take Action, Champion better care, and empower their patients ...
... announced today that HHS has awarded a contract for $500 ... manufacture and deliver 20 million doses of a next generation ... would be recommended in the event of a smallpox outbreak ... immune systems. The full supply of the vaccine will be ...
... Mental Health Services Administration (SAMHSA) today announced that ... three years to the state of Iowa ... The first year award is $400,000. This grant ... intervention and treatment services for youth suicide prevention ...
Cached Medicine News:Health News:Fertility Test at Home Possible With a New Kit 2Health News:Marriage Could Lift One Out of Depression, New Study 2Health News:Brain Tumor Patients Survival Depends on Predicting Treatment Responses Earlier 2Health News:AAPPO Launches ACT on Diabetes Initiative to Promote Improved Diabetes Care 2Health News:HHS Buys Next Generation Smallpox Vaccine 2Health News:HHS Buys Next Generation Smallpox Vaccine 3Health News:Iowa to Receive Grant Funding for Youth Suicide Prevention, Early Intervention 2
(Date:9/2/2014)... -- Particle Sciences, the leading CDMO for drug eluting ... manufacturing capabilities with the addition of a new 18mm ... Associate Director Clinical Production, "The company has been expanding ... equipment and staff across the board, all aimed at ... 6000ft 2 of operating cleanroom and cGMP warehouse ...
(Date:9/2/2014)... 2, 2014  Edison Nation Medical, the premier ... the American Association for Respiratory Care ( AARC ... specialists. Edison Nation Medical, which brings 12+ years ... commercialize their innovation ideas, will work with AARC ... than 50,000 respiratory therapists in bringing their product ...
(Date:9/2/2014)... , Sept. 2, 2014  PANTHERx Specialty ... Specialty Pharmacy Accreditation from URAC, a ... that establishes quality standards for the health care ... The URAC accreditation process demonstrates ... a framework to improve business processes through benchmarking ...
Breaking Medicine Technology:Particle Sciences Expands Drug Eluting Device Capabilities and Overall Clinical Trial Manufacturing Resources 2Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 2Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 3PANTHERx Specialty Pharmacy Applying for URAC Specialty Pharmacy Accreditation 2
... , , , ... With Eczema , , , ... launched guidance to,help parents reduce the burden of eczema on children living with this,disease. Experts from ... have come,together to agree a consensus of ,top tips, which focus on avoiding,situations that trigger painful ...
... , PITTSBURGH , May 19 Mylan Inc. ... private placement of $550 million aggregate principal amount of ... principal amount of 7.875% Senior Notes due 2020.  Mylan is using ... placement to prepay a portion of its outstanding term loans, thereby ...
Cached Medicine Technology:Experts Provide Guidance to Support Better Prevention of Eczema in Children 2Experts Provide Guidance to Support Better Prevention of Eczema in Children 3Experts Provide Guidance to Support Better Prevention of Eczema in Children 4Mylan Announces Completion of Senior Notes Offering 2
... Minimize Patient Trauma and Increase Staff Protection ... (10 Fr, 12 Fr, 14 Fr, 16 ... Suction Catheters with Contro-Vac Valves and DeLee ... potential for inflammation,during suctioning. Each catheter utilizes ...
SAFE-T-VAC Coil Packed Suction Catheters Kits, Sterile without Solution...
Sterile, Coil Packed Suction Catheter Mini Tray with (2) Walleted SAFESKIN PURPLE NITRILE Latex-Free Exam Gloves...
Clear plastic sleeve envelopes a plastic suction catheter. Sleeve slides over exudate to reduce potential clinician contact....
Medicine Products: