Navigation Links
New TB vaccine approach shows promise in mice

An experimental vaccine composed of a genetically modified bacterium closely related to the bacterium that causes tuberculosis (TB) has been found to protect mice against TB infection, according to a study appearing online September 4 in the journal Nature Medicine. The research was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health.

TB, a respiratory disease that according to World Health Organization estimates killed 1.7 million people worldwide in 2009, is caused by the bacterium Mycobacterium tuberculosis (Mtb). A vaccine to prevent TB infection, called bacille Calmette-Gurin (BCG), is widely available, but it confers limited protection and can cause severe TB infection in infants infected with HIV, restricting its use in certain countries.

In the new study, led by William R. Jacobs, Jr., Ph.D., of the Albert Einstein College of Medicine in New York, researchers genetically modified M. smegmatis, a relative of Mtb that is generally harmless to humans. Specifically, the scientists replaced a set of M. smegmatis genes called esx-3, believed to be important because its DNA sequence is unusually consistent across species, with the corresponding but not identical set of genes from Mtb. They vaccinated mice with this modified form of M. smegmatis, essentially delivering the Mtb version of esx-3 without the bacterial components that would cause infection, and then challenged the mice with Mtb. In mice that received the experimental vaccine, levels of TB bacteria were 1,000 times lower than in those that received BCG. This suggests that modified M. smegmatis induces a strong immune response in mice that can protect them from TB.

The study authors are encouraged by their study results, but they caution that further testing of the modified M. smegmatis TB vaccine is needed before it might be evaluated in human clinical trials.


Contact: Nalini Padmanabhan
NIH/National Institute of Allergy and Infectious Diseases

Related medicine news :

1. More U.S. Tweens Getting Recommended Vaccines
2. GEN reports on advances in DNA vaccine delivery and production
3. Single vaccines to protect against both rabies and Ebola
4. U.S.-Mandated Report Finds Vaccines Safe for Kids
5. Few health problems are caused by vaccines, IOM report finds
6. Kids Benefit From Flu Vaccine via Shot or Spray, Study Finds
7. Mayo Clinic receives FDA approval for ovarian and breast cancer vaccines
8. Researchers create new experimental vaccine against chikungunya virus
9. New TB vaccine enters proof-of-concept trial in people living with HIV
10. Fine-tuning the flu vaccine for broader protection
11. Vaccine to Prevent Heroin High Works in Animals
Post Your Comments:
(Date:11/26/2015)... , ... November 26, 2015 , ... Indosoft Inc., developer ... of an application server to improve system efficiency and reliability. , The new Q-Suite ... of these standards, the system avoids locking itself into a specific piece of software ...
(Date:11/25/2015)... Neb. (PRWEB) , ... November 25, 2015 , ... ... staffing companies, has been recognized once again for its stellar workplace culture with ... to Work.” , Medical Solutions’ Cincinnati office was named a finalist ...
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert is ... One Beat ” campaign. The partnership between the two groups began in 2014 with ... International’s cause. , MAP International was founded in 1954 and is an international Christian-based ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... for physicians and athletic programs, launches new Wimbledon Athletics Facebook page ... testing young athletes for unsuspected cardiac abnormalities. About 2,000 people under the age ...
(Date:11/25/2015)... ... , ... Beddit® has launched a new Android app for use ... a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and makes ... by a proprietary algorithm. Beddit analyzes the data to provide an easy to understand ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... FRANCISCO , November 26, 2015 ... billion by 2022, according to a new report by Grand ... Chronic Kidney Disease (CKD) which demands kidney transplantation is expected ... and cost effective substitute for organ transplantation. --> ... billion by 2022, according to a new report by Grand ...
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Competitive Intelligence, ... --> ) has ... Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... 2015 Research and Markets ( ) ... Care Market by Type (Dressings, Therapy Devices, Active Wound ... Out-Patient Facility), and Geography - Global Forecast to 2020" ... --> --> The purpose of this ... of the global advanced wound care market. It involves ...
Breaking Medicine Technology: