Navigation Links
New TB vaccine approach shows promise in mice
Date:9/6/2011

An experimental vaccine composed of a genetically modified bacterium closely related to the bacterium that causes tuberculosis (TB) has been found to protect mice against TB infection, according to a study appearing online September 4 in the journal Nature Medicine. The research was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health.

TB, a respiratory disease that according to World Health Organization estimates killed 1.7 million people worldwide in 2009, is caused by the bacterium Mycobacterium tuberculosis (Mtb). A vaccine to prevent TB infection, called bacille Calmette-Gurin (BCG), is widely available, but it confers limited protection and can cause severe TB infection in infants infected with HIV, restricting its use in certain countries.

In the new study, led by William R. Jacobs, Jr., Ph.D., of the Albert Einstein College of Medicine in New York, researchers genetically modified M. smegmatis, a relative of Mtb that is generally harmless to humans. Specifically, the scientists replaced a set of M. smegmatis genes called esx-3, believed to be important because its DNA sequence is unusually consistent across species, with the corresponding but not identical set of genes from Mtb. They vaccinated mice with this modified form of M. smegmatis, essentially delivering the Mtb version of esx-3 without the bacterial components that would cause infection, and then challenged the mice with Mtb. In mice that received the experimental vaccine, levels of TB bacteria were 1,000 times lower than in those that received BCG. This suggests that modified M. smegmatis induces a strong immune response in mice that can protect them from TB.

The study authors are encouraged by their study results, but they caution that further testing of the modified M. smegmatis TB vaccine is needed before it might be evaluated in human clinical trials.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. More U.S. Tweens Getting Recommended Vaccines
2. GEN reports on advances in DNA vaccine delivery and production
3. Single vaccines to protect against both rabies and Ebola
4. U.S.-Mandated Report Finds Vaccines Safe for Kids
5. Few health problems are caused by vaccines, IOM report finds
6. Kids Benefit From Flu Vaccine via Shot or Spray, Study Finds
7. Mayo Clinic receives FDA approval for ovarian and breast cancer vaccines
8. Researchers create new experimental vaccine against chikungunya virus
9. New TB vaccine enters proof-of-concept trial in people living with HIV
10. Fine-tuning the flu vaccine for broader protection
11. Vaccine to Prevent Heroin High Works in Animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... , ... May 04, 2016 , ... ... certified that their Vasont Universal Integrator (VUI) extension supports the latest release of ... of Adobe FrameMaker 2015 interlace the process of creating, editing and storing XML. ...
(Date:5/3/2016)... ... 2016 , ... An accurate diagnosis is critical to planning ... through expanding activities that embrace training, standards, technology and new methods of making ... , In support of this important work, ASCP is co-sponsoring the inaugural Global ...
(Date:5/3/2016)... ... May 03, 2016 , ... According to an article ... issues related to medical care in the hospital setting, which include excessive wait ... hospital staff. Commenting on this article, the founder of House Call Doctor Los ...
(Date:5/3/2016)... ... ... Desmond-Hellmann, chief executive officer of the Bill & Melinda Gates Foundation, will call on ... address at Georgia State University’s spring commencement on Saturday, May 7 at ... scientist, physician and executive, Desmond-Hellmann leads the Gates Foundation’s efforts to help more children ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... – a web application that helps people assess their risk of developing Alzheimer’s ... app will provide users a “Risk Reduction Score™” that summarizes how their lifestyle ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... PUNE, India , May 3, 2016 /PRNewswire/ ... Market 2016 Research Report provides a basic overview ... manufacturing technology, post which the surgical mesh report ... the market. Complete report on Surgical ... company profiles and 98 tables and figures is ...
(Date:5/2/2016)... NEW YORK , May 2, 2016 Leading Economies ... Growth Ethiopia 10.2 Côte d,Ivoire 8.6 Uzbekistan 8 Ireland 7.8 India 7.3, ... TechSci Research, BRICS nations , which comprises of Brazil ... China and South Africa , registered the fastest ... economic slowdown in China , recession in Brazil ...
(Date:5/2/2016)... N.J. , May 2, 2016  Celsion ... development company, today announced data from the first ... escalating clinical trial (the OVATION Study) combining GEN-1, ... care for the treatment of newly-diagnosed patients with ... followed by interval debulking surgery.  In the first ...
Breaking Medicine Technology: