Navigation Links
New TB booster shows promise
Date:3/16/2010

A booster shot appears to improve tuberculosis (TB) resistance in previously vaccinated adults, according to new research in South Africa.

The study has been published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"The world urgently needs new, better vaccines against TB," said Willem Hanekom, M.B.Ch.B., associate professor and co-director, South African Tuberculosis Vaccine Initiative (SATVI). "It is important to test the safety of these vaccines in settings where TB is very common, such as South Africa."

Every year 1.7 million people die from TB, according to the World Health Organization. This study is the first to report results from testing an adenovirus-35-based vaccine in humans. Adenovirus-35 is attractive to vaccine developers because fewer humans have been exposed to this strain of the virus, compared with many other adenoviruses, and the immunity from exposure is therefore less likely to interfere with the vaccine's action.

The Aeras-402 vaccine, developed by Aeras Global Tuberculosis Foundation and Crucell, was made by weakening the virus in the lab, so that it can no longer replicate and cause disease. Parts of the TB bacterium that are important to stimulate the immune system (antigens) were then inserted into the virus.

"We showed that the vaccine was safe in healthy adults who have previously been vaccinated with the current TB vaccine, BCG," said Dr. Hanekom. "Aeras-402 was able to stimulate the immune system in a manner thought to be important for protection against TB. This included activation of both CD4 and CD8 T cells. Potent activation of CD8 T cells by a new TB vaccine has not been demonstrated to date."

Animal testing of AERAS-402 had showed promise, and the researchers had expected to see stimulation of CD4 cells, but were "pleasantly surprised" at how well CD8 T cells were also stimulated.

"We are completing a trial of Aeras-402 in babies, to make sure that the vaccine is safe and immunogenic in this population," said Dr. Hanekom. "If all the studies go well, we will proceed with a Phase IIb study of Aeras-402 in up to 4,000 BCG-vaccinated babies, who will receive either the vaccine or a placebo in their first year of life. The results should indicate whether the vaccine may prevent TB disease. An effective booster vaccine would ultimately reduce the incidence of TB disease and, consequently, the spread of the TB pandemic."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Many Vaccine Booster Shots Unnecessary: Study
2. Parents Should Postpone Child Vaccine Booster: CDC
3. Hydra Booster Energizes Ordinary Drinking Water for Better Absorption and Optimum Hydration, Stopping Symptoms of 'Hidden' Dehydration
4. Booster vaccination may help with possible future avian influenza pandemic
5. Chickenpox Protection: Get That Booster
6. Mt. Diablo Region YMCA to Celebrate 50 Years of Community Service at 28th Annual Boosters Gala on October 17, 2008
7. Parents of new babies should be considered for a whooping cough booster, say experts
8. Stroke Drug Might Be a Memory-Booster
9. Riley Hospital-IU study finds booster car seats not being used appropriately
10. Improper Use of Booster Seats Puts Many Kids at Risk
11. Why Some Vaccines May Require A Booster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... Viejo, California (PRWEB) , ... June 26, 2016 , ... ... Final Cut Pro X. , "Film editors can give their videos a whole new ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: