Navigation Links
New TB booster shows promise
Date:3/16/2010

A booster shot appears to improve tuberculosis (TB) resistance in previously vaccinated adults, according to new research in South Africa.

The study has been published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"The world urgently needs new, better vaccines against TB," said Willem Hanekom, M.B.Ch.B., associate professor and co-director, South African Tuberculosis Vaccine Initiative (SATVI). "It is important to test the safety of these vaccines in settings where TB is very common, such as South Africa."

Every year 1.7 million people die from TB, according to the World Health Organization. This study is the first to report results from testing an adenovirus-35-based vaccine in humans. Adenovirus-35 is attractive to vaccine developers because fewer humans have been exposed to this strain of the virus, compared with many other adenoviruses, and the immunity from exposure is therefore less likely to interfere with the vaccine's action.

The Aeras-402 vaccine, developed by Aeras Global Tuberculosis Foundation and Crucell, was made by weakening the virus in the lab, so that it can no longer replicate and cause disease. Parts of the TB bacterium that are important to stimulate the immune system (antigens) were then inserted into the virus.

"We showed that the vaccine was safe in healthy adults who have previously been vaccinated with the current TB vaccine, BCG," said Dr. Hanekom. "Aeras-402 was able to stimulate the immune system in a manner thought to be important for protection against TB. This included activation of both CD4 and CD8 T cells. Potent activation of CD8 T cells by a new TB vaccine has not been demonstrated to date."

Animal testing of AERAS-402 had showed promise, and the researchers had expected to see stimulation of CD4 cells, but were "pleasantly surprised" at how well CD8 T cells were also stimulated.

"We are completing a trial of Aeras-402 in babies, to make sure that the vaccine is safe and immunogenic in this population," said Dr. Hanekom. "If all the studies go well, we will proceed with a Phase IIb study of Aeras-402 in up to 4,000 BCG-vaccinated babies, who will receive either the vaccine or a placebo in their first year of life. The results should indicate whether the vaccine may prevent TB disease. An effective booster vaccine would ultimately reduce the incidence of TB disease and, consequently, the spread of the TB pandemic."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Many Vaccine Booster Shots Unnecessary: Study
2. Parents Should Postpone Child Vaccine Booster: CDC
3. Hydra Booster Energizes Ordinary Drinking Water for Better Absorption and Optimum Hydration, Stopping Symptoms of 'Hidden' Dehydration
4. Booster vaccination may help with possible future avian influenza pandemic
5. Chickenpox Protection: Get That Booster
6. Mt. Diablo Region YMCA to Celebrate 50 Years of Community Service at 28th Annual Boosters Gala on October 17, 2008
7. Parents of new babies should be considered for a whooping cough booster, say experts
8. Stroke Drug Might Be a Memory-Booster
9. Riley Hospital-IU study finds booster car seats not being used appropriately
10. Improper Use of Booster Seats Puts Many Kids at Risk
11. Why Some Vaccines May Require A Booster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... WHAT: ... networking and recognition opportunities as well as advocacy for the state and region‘s ... on February 23. The Council's Innovation Forecast event highlights innovation throughout the ...
(Date:2/24/2017)... ... , ... With millions of Americans and people worldwide struggling ... are aware of our options and are empowered with strength and information throughout ... its newest edition of "Vision and Hearing" in USA Today, that will educate ...
(Date:2/24/2017)... , ... February 24, 2017 , ... Yisrayl Hawkins, Pastor ... on Bible Prophecy concerning this present generation. Yisrayl makes an astounding statement when ... generation. He explains that the Bible details the current times so plainly that ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to ... Elite division on February 12th. Ms. Esparza qualified into this prestigious status ... competition held in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... the La Gorce Country Club in Miami Beach to host its Swirl: Miami ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... YORK , Feb. 23, 2017  The ... 330.6 million by 2021 from USD 275.9 million ... Read the full report: http://www.reportlinker.com/p04718602-summary/view-report.html ... increasing spending on pharmaceutical R&D, and growth in ... driving the market growth for particle counters. On ...
(Date:2/23/2017)... , Feb 23, 2017 Research and Markets ... Price Analysis and Strategies - 2016" report to their offering. ... The latest ... provides drug pricing data and benchmarks in the global Autism Spectrum ... What are the key drugs marketed for Autism ...
(Date:2/23/2017)... CITY, Calif., Feb. 23, 2017 Nevro Corp. (NYSE: ... evidence-based solutions for the treatment of chronic pain, today reported ... December 31, 2016. 2016 Accomplishment & Highlights: ... full year 2016, an increase of 228% as reported, over ... for 2016, an increase of 612% over the prior year ...
Breaking Medicine Technology: