Navigation Links
New Sweetness Detectors Found in Human Taste Cells
Date:3/7/2011

MONDAY, March 7 (HealthDay News) --Taste cells apparently host more sugar detectors than previously thought, including ones formerly thought to exist only in the pancreas and intestines, new research suggests.

The finding could lead to the development of new interventions designed to help prevent overeating, the study authors say.

"Detecting the sweetness of nutritive sugars is one of the most important tasks of our taste cells," senior author Dr. Robert F. Margolskee, a molecular neurobiologist at the Monell Chemicals Senses Center in Philadephia, said in a news release. "Many of us eat too much sugar and to help limit overconsumption, we need to better understand how a sweet taste cell 'knows' something is sweet."

Margolskee and his colleagues report their observations in this week's issue of the Proceedings of the National Academy of Sciences.

Until now, investigators had focused on one particular taste cell receptor (known as T1r3+Tr3) as the main detector of all things sweet, including both natural sugars and artificial sweeteners.

This sensor, however, did not appear to account for all aspects of sweetness detection.

So, the authors harnessed high-tech molecular and cellular lab methods to explore whether or not additional sugar sensors -- those central to the digestive process that takes place in both the intestine and pancreas -- might also be present in taste cells.

The result: those same sugar sensors were thriving in taste cells. In fact, several sugar sensors found in the intestine and pancreas were fingered as being present in the same taste cells that house the well-known T1r3+T3r receptor.

For example, the newly located taste cell receptor known as SGLT1 (previously detected solely in the intestine) was found to account for the sweet taste that registers when consuming a pinch of table salt. Another newly found sensor, known as KATP and previously attributed solely to the pancreas, is thought to play a role in restricting taste cell sensitivity to sugar to discourage overconsumption of sweetened foods.

"Sweet taste cells have turned out to be quite complex. The presence of the KATP channel suggests that taste cells may play a role in regulating our sensitivity to sweet taste under different nutritional conditions," first author Karen K. Yee, a cellular physiologist at Monell, said in the same news release. "This knowledge may someday help us understand how to limit overconsumption of sweet foods."

More information

For more on the sense of taste, visit the National Institute on Deafness and Other Communication Disorders.

--Alan Mozes

SOURCE: Proceedings of the National Academy of Sciences, March 7, 2011, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. One-third of antimalarial medicines sampled in 3 African nations found to be substandard
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. Highmark Foundation Awards $120,000 to the American Heart Association
4. Stuttering Foundation Hails New Research
5. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
6. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
7. Corbett Accel Healthcare Group Mourns Passing of Founder Frank J. Corbett
8. Reliv Foundation Donates $450,000 In Nutritional Supplements to Haitian Relief Efforts
9. Kaiser Foundation Health Plan and Hospitals Report Fourth Quarter and Fiscal Year 2009 Financial Results
10. Instaflex Announces Proceeds Agreement with Arthritis Foundation
11. AMERICAN IDOL to Benefit the UN Foundation Fund for Haiti Thursday, February 25, on FOX
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Sweetness Detectors Found in Human Taste Cells
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: