Navigation Links
New Study Reveals Protein Produced by Spleen Reduces Risk of Deadly Lung Infection
Date:1/23/2010

In a lead study published in the American Journal of Respiratory Critical Care Medicine, Ping Wang, MD Wang and his colleagues used an experimental medicine called MFG-E8 on the heels of ischemia and found that it significantly lowered the risk for ischemia reperfusion injury, a condition caused when blood flow to the organ is interrupted (during surgery, injury or disease) and then re-established.

Manhasset, NY (Vocus) January 22, 2010 -- One to five percent of people who undergo surgery for gastrointesintal problems experience a potentially life-threatening condition: a temporary loss of oxygen that can set in motion a rogue inflammatory response that can lead to organ failure.

Ping Wang, MD, a scientist at The Feinstein Institute for Medical Research in Manhasset, NY, is testing the benefits of an experimental medicine that can clear away dying cells and reduce the risk for ischemia reperfusion injury. In a lead study published in the American Journal of Respiratory Critical Care Medicine, Dr. Wang and his colleagues used an experimental medicine called MFG-E8 on the heels of ischemia and found that it significantly lowered the risk for ischemia reperfusion injury, a condition caused when blood flow to the organ is interrupted (during surgery, injury or disease) and then re-established. Normally, when tissue suffers from a temporary loss of oxygen, the body makes an unusual response when the oxygen starts to flow again. It sets off an inflammatory response. These inflammatory cells actually target tissue and can trigger multiple organ failure. The lung is most susceptible to this type of injury, which is why in humans it can be deadly.

MFG-8 blocked the acute lung injury in an animal model of ischemic reperfusion. Fifty percent of the animals exposed to MFG-8 survived, according to Dr. Wang. MFG-8 is a protein normally produced by the spleen to enhance clearance of dying cells. The Feinstein scientists made a recombinant human protein. The idea to use the protein emerged after their studies showed that MFG-8 levels drop markedly on the heels of ischemia reperfusion. Spleen cells just can't produce enough of the substance to clean up the dead or dying cells. If the cells are not removed -- and this cellular garbage continues to accumulate -- this cell death (called necrosis) can cause acute lung injury.

They found that the medicine helped clear out 90 percent of the dead cells in the hard-hit lung. It also reduced inflammation at the site. And the most hopeful news was that half of the animals survived the injury. The work in the laboratory will continue to address questions that need answering: Will the protein be harmful to patients? How much will be enough to protect against organ failure?

Right now, there is no approved medicine to treat ischemic reperfusion. Dr. Wang said that there are 50,000 to 100,000 deaths a year related to this intestinal injury.

About The Feinstein Institute for Medical Research
Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research (www.feinsteininstitute.org) is home to international scientific leaders in cancer, leukemia, lymphoma, Parkinson's disease, Alzheimer's disease, psychiatric disorders, rheumatoid arthritis, lupus, sepsis, inflammatory bowel disease, diabetes, human genetics, neuroimmunology, and medicinal chemistry. Feinstein researchers are developing new drugs and drug targets, and producing results where science meets the patient, annually enrolling some 10,000 subjects into clinical research programs.

Jamie Talan, science writer-in-residence
516-562-1232

# # #

Read the full story at http://www.prweb.com/releases/Feinstein_Institute/study/prweb3497964.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Study Reveals Protein Produced by Spleen Reduces Risk of Deadly Lung Infection
(Date:4/21/2017)... Maine (PRWEB) , ... April 21, 2017 , ... ... today announced it’s been named Agency of Record (AOR) for Theravent, Inc. ... or eliminate snoring. Theravent’s parent company, Foundation Consumer Healthcare, is now working to ...
(Date:4/21/2017)... Arvada, CO (PRWEB) , ... April 21, 2017 ... ... health and performance system, has partnered with O2X , an active lifestyle ... are focused on improving the health of firefighters, police offers, first responders, military ...
(Date:4/21/2017)... Columbia (PRWEB) , ... April 21, 2017 , ... ... treating people who wish to overcome their mental health struggles. The Alive team uses ... Vic LeBouthillier says: “Our approach in dealing with a mental health struggle is based ...
(Date:4/21/2017)... , ... April 21, 2017 , ... ... held the much anticipated Regional Primary Care Spring Symposium on April 1, 2017 ... local medical community, offering physicians and healthcare providers an opportunity to learn about ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... quality-based imaging practices, is seeking candidates to serve on its Accreditation and ... , “RadSite’s ultimate mission is improving image quality and reducing patient ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017  SARES•REGIS Group leased the first ... at Conejo Spectrum Business Park in ... Biotherapeutics, Inc. , a biopharmaceutical company developing meaningful ... that have been underserved by scientific innovation, with ... cancer, autoimmune and infectious disease. Before ...
(Date:4/18/2017)... Research and Markets has announced the addition ... their offering. ... devices market to grow at a CAGR of 6.35% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
(Date:4/18/2017)... 18, 2017 Research and Markets has ... States Molecular Imaging Equipment and Radiopharmaceuticals Market, Forecast to 2023" ... ... equipment revenues as well as growth in the number of ... value to market participants that design and manufacture molecular imaging ...
Breaking Medicine Technology: