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New Study Reveals Protein Produced by Spleen Reduces Risk of Deadly Lung Infection
Date:1/23/2010

In a lead study published in the American Journal of Respiratory Critical Care Medicine, Ping Wang, MD Wang and his colleagues used an experimental medicine called MFG-E8 on the heels of ischemia and found that it significantly lowered the risk for ischemia reperfusion injury, a condition caused when blood flow to the organ is interrupted (during surgery, injury or disease) and then re-established.

Manhasset, NY (Vocus) January 22, 2010 -- One to five percent of people who undergo surgery for gastrointesintal problems experience a potentially life-threatening condition: a temporary loss of oxygen that can set in motion a rogue inflammatory response that can lead to organ failure.

Ping Wang, MD, a scientist at The Feinstein Institute for Medical Research in Manhasset, NY, is testing the benefits of an experimental medicine that can clear away dying cells and reduce the risk for ischemia reperfusion injury. In a lead study published in the American Journal of Respiratory Critical Care Medicine, Dr. Wang and his colleagues used an experimental medicine called MFG-E8 on the heels of ischemia and found that it significantly lowered the risk for ischemia reperfusion injury, a condition caused when blood flow to the organ is interrupted (during surgery, injury or disease) and then re-established. Normally, when tissue suffers from a temporary loss of oxygen, the body makes an unusual response when the oxygen starts to flow again. It sets off an inflammatory response. These inflammatory cells actually target tissue and can trigger multiple organ failure. The lung is most susceptible to this type of injury, which is why in humans it can be deadly.

MFG-8 blocked the acute lung injury in an animal model of ischemic reperfusion. Fifty
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