Navigation Links
New Study May Impact Practice Guidelines for Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation
Date:11/19/2013

New York, NY (PRWEB) November 19, 2013

The Cardiothoracic Surgical Trials Network (CTSN), whose Data and Clinical Coordinating Center is at Icahn School of Medicine at Mount Sinai, is reporting for the first time evidence on whether or not there is any significant difference between the two current surgical approaches to treat patients with severe ischemic mitral regurgitation -- mitral valve repair and mitral valve replacement.

The findings presented on November 18 at the American Heart Association’s Scientific Sessions 2013 and published simultaneously by the New England Journal of Medicine, report similar clinical outcomes one-year following mitral valve surgery for both surgical approaches. Although patient clinical outcomes were similar, mitral valve replacement was shown to be more durable than repair.

“Ischemic mitral regurgitation is an important public health problem affecting as many as two million Americans. Our study is the first definitive clinical trial to address the relative merits of mitral valve repair versus mitral valve replacement surgery in patients suffering from severe ischemic mitral regurgitation,” says Annetine C. Gelijns, PhD, Professor and Chair of the Department of Health Evidence and Policy at Icahn School of Medicine at Mount Sinai, who is the corresponding author for the NEJM study and principal investigator for the Data and Clinical Coordinating Center based at Mount Sinai for the NIH-sponsored Cardiothoracic Surgical Trials Network (CTSN) which conducted the clinical trial study.

Ischemic mitral regurgitation occurs when blood backflows into the left atrium from the left ventricle of the heart due to improper closure of the mitral valve. The condition often develops as a complication from a heart attack and subsequent enlargement of the left ventricle, the heart’s main pumping chamber. If not surgically corrected, the condition has been reported to potentially have a one-year mortality risk as high as 40 percent.

Currently, practice guidelines recommend valve repair or replacement for severe ischemic mitral regurgitation. However, lack of evidence has led to uncertainty and variation in surgical practice, although surgeons’ use of repair has increased over time. Previous research has shown mitral valve repair has lower operative mortality and complications, while mitral valve replacement may provide better long-term correction of mitral regurgitation.

“These results may impact the surgical care of patients experiencing severe ischemic mitral regurgitation and offer the strongest evidence to date to inform future surgical practice guidelines,” says Michael K. Parides, PhD, Professor of Biostatistics in the Department of Health Evidence and Policy at Icahn School of Medicine at Mount Sinai, the principal statistician for the CTSN.

This multicenter, randomized clinical trial included 22 clinical centers in North America randomizing 251 patients. It evaluated the safety and effectiveness of mitral valve repair and mitral valve replacement in patients with severe ischemic mitral regurgitation. Comparative effectiveness was based on the degree of left ventricular remodeling, mortality, adverse events, recurrent mitral regurgitation, hospitalizations, and quality of life one-year after surgery.

“While our study results clearly demonstrate that patient outcomes with replacement and repair are similar one-year after surgery, our ongoing patient follow-up is extremely important, as it will reveal any consequences for patients whose mitral regurgitation has recurred,” says Alan J. Moskowitz, MD, Professor and Vice-Chair of the Department of Health Evidence and Policy at Icahn School of Medicine at Mount Sinai and study co-author.

The CTSN has eight core clinical centers in the U.S. and Canada. The CTSN Data and Clinical Coordinating Center, based at Icahn School of Medicine at Mount Sinai, directs each of its clinical trial’s design, methodologies, ethical research concerns, study data, analysis, and reporting.

As principal investigator for CTSN’s Data and Clinical Coordinating Center based at Mount Sinai, Dr. Gelijns previously received financial compensation as a consultant for InHealth’s Research Council, a not-for-profit agency which has supported some of the study-related analyses.

This study was presented as the Late-Breaking Clinical Trial (Abstract 19636): Severe Ischemic Mitral Regurgitation: Is it Better to Repair or Replace the Valve?

About the Mount Sinai Health System
The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven member hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.

The System includes approximately 6,600 primary and specialty care physicians, 12-minority-owned free-standing ambulatory surgery centers, over 45 ambulatory practices throughout the five boroughs of New York City, Westchester, and Long Island, as well as 31 affiliated community health centers. Physicians are affiliated with the Icahn School of Medicine at Mount Sinai, which is ranked among the top 20 medical schools both in National Institutes of Health funding and by U.S. News & World Report.

For more information, visit http://www.mountsinai.org.

Find Mount Sinai on:
Facebook: http://www.facebook.com/mountsinainyc
Twitter @mountsinainyc
YouTube: http://www.youtube.com/mountsinainy

Read the full story at http://www.prweb.com/releases/2013/11/prweb11341046.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Study may impact guidelines for mitral valve surgery for severe ischemic mitral regurgitation
2. Advanced CT imaging proves as accurate as invasive tests to assess heart blockages, study shows
3. Chicago man breathes again thanks to Northwestern Medicine study
4. Study finds youth prefer and benefit more from rapid point-of-care HIV testing
5. Study: Ureteral injury during robot-assisted prostate surgery
6. Study: Odds of rehospitalization of cognitively impaired varies by discharge destination
7. A CNIO study recreates the history of life through the genome
8. Dr. Joe Dentistry Promotes Dental Exams as New Study Links Heart Disease to Oral Health
9. Study questions hypothermia treatment for cardiac arrest
10. Mayo Clinic-led study: 2 drugs do not improve kidney function in acute heart failure patients
11. New study shows spironolactone reduces heart failure hospitalizations, but not mortality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... 2016 , ... Nike Rugby Camp's success is due in large part to ... Elite Rugby Camps and current Nike Camp director, has offered an all abilities rugby ... “I’m excited for our eighth summer here in San Diego,” says Willis. "We take ...
(Date:5/4/2016)... ... May 04, 2016 , ... All-Star Insurance of Northeast ... the people of their local community. The agency pledges to select a new ... hope is to bring awareness to important local causes with fundraising and other ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... Dr. Elyson ... wisdom tooth removal surgery at their office. Wisdom tooth removal, a common dental procedure, ... always problematic, they often are improperly erupted, resulting in risks of complications. By providing ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... Francesca Loparco, ... changed her life forever with a same-day LASIK procedure at Christenbury Eye ... eyesight. Dr. Jonathan Christenbury performed her surgery the same day as her in-office consultation ...
(Date:5/4/2016)... ... May 04, 2016 , ... Bayco Products ... tactical (6.7 inch) dual-light flashlights in models NSP-9842XL and NSR-9844XL . , ... starting at $59.95) uses 2 included CR-123 batteries to produce up to 650 ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016 BioNovus Innovations LLC and ... Advancing Medical Innovation (IAMI) today announced a new ... and medical devices. An agreement between ... to license, develop and commercialize medical innovations advanced ... "This partnership represents a significant advance in our ...
(Date:5/3/2016)... , May 3, 2016 ACME ... Whelan and Delaware County Councilman ... Nasal Spray in all ACME pharmacies across ... for Disease Control and Prevention (CDC), naloxone has saved 26,463 lives ... officers in Delaware County were authorized to ...
(Date:5/3/2016)... --  Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that it is celebrating Hepatitis Awareness Month with ... who tell their personal story and encourage those at risk to get tested and begin ... ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
Breaking Medicine Technology: