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New Study Finds Cholesterol-Related Gene Associated with Mild Cognitive Impairment, a Precursor of Alzheimer's Disease
Date:3/9/2010

Scientists find that a genetic mutation causing a common hereditary form of high blood cholesterol dramatically increase the risk of MCI.

(PRWEB) March 9, 2010 -- A new study from scientists in the United States and Spain has found that a mutation in a gene causing a common hereditary form of high blood cholesterol is associated with “mild cognitive impairment” (MCI), a precursor stage of Alzheimer’s disease. Worldwide, Alzheimer’s disease is the most common form of dementia affecting elderly individuals. It is usually preceded by a period characterized mainly by memory deficits known as MCI. The study will be published in the March issue of the American Journal of Medicine.

Leading the study were Dr. Miguel Pappolla and Dr. Kumar Sambamurti from the Medical University of South Carolina in Charleston and Dr. Daniel Zambon from the University of Barcelona in Spain. Their groups of scientists examined memory and other brain functions in a group of patients with familial hypercholesterolemia, a hereditary condition caused by a mutation in the low density lipoprotein receptor, a protein involved in the transport of cholesterol into cells. Patients with familial hypercholesterolemia showed a very high incidence of MCI (21 percent) when compared with age-matched individuals without the disease (2.9 percent).

For almost a decade, it has been suspected that individuals with high blood cholesterol during mid-life may carry a higher risk of developing Alzheimer’s disease. However, the evidence for t
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New Study Finds Cholesterol-Related Gene Associated with Mild Cognitive Impairment, a Precursor of Alzheimer's Disease
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