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New Studies Support Use of Intravenous Vimpat(R) (lacosamide) (C-V) in Hospital and Emergency Settings
Date:12/7/2009

or intravenous administration. The initial dose should be 50 mg twice daily (100 mg per day). Vimpat can be increased weekly by 100 mg/day, given as two divided doses, up to the recommended maintenance dose of 200 to 400 mg/day. When switching from oral Vimpat, the initial total daily intravenous dosage of Vimpat should be equivalent to the total daily dosage and frequency of oral Vimpat and should be infused intravenously over a period of 30 to 60 minutes. At the end of the intravenous treatment period, the patient may be switched to Vimpat oral administration at the equivalent daily dosage and frequency of the intravenous administration.

Summary of Intravenous Vimpat Data Presented at 2009 AES Annual Meeting

Abstract: Pharmacokinetic evaluation of intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures

In this 160-patient analysis of the lacosamide long-term open-label extension trial, patients receiving oral lacosamide were converted to therapeutically equivalent intravenous doses, and grouped into three cohorts based on infusion duration. Results showed that intravenous lacosamide provided similar plasma concentrations as those associated with oral lacosamide, across consecutive dosing days and regardless of infusion durations.

  • Average Ctrough and Cmax plasma concentrations (minimum and maximum concentrations of a drug in the body after dosing) for oral and intravenous lacosamide appeared dose-proportional across consecutive dosing days within a therapeutic dose range.
  • Plasma concentration levels were similar across all cohorts.

Poster Session 2, Sunday, December 6, 4:00 pm - 5:00 pm (Abstract 2.223)

Willi Cawello, PhD 1, Gregory Krauss, MD 2, Melissa Brock, PharmD 3, Andrea Eggert PharmD, BCPP 4

1 SCHWARZ BIOSCIENCES, GmbH, A Member of the UCB Group of Comp
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SOURCE UCB
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