Navigation Links
New Stem Cell Growth Strategy Could Yield Better Way to Treat Brain Lesions
Date:5/16/2013

Durham, NC (PRWEB) May 16, 2013

Researchers have found a new way to increase the survival of stem cells injected into the brain. The discovery might one day prove useful in developing new treatments for neurological disorders — especially brain lesions, which among other things can provoke seizures and indicate multiple sclerosis or certain forms of cancer.

The study was performed by Sushma Chaubey, Ph.D., and John H. Wolfe, V.M.D., Ph.D., of the Children's Hospital of Philadelphia’s Research Institute and the University of Pennsylvania School of Veterinary Medicine. It appears in the current issue of STEM CELLS Translational Medicine.

Many medical experts have long believed that neural stem cells (NSCs) have great potential for treating neurological diseases. However, the problem is that just a small number of NSCs can be transplanted into the brain, yielding relatively low levels of new cell growth and, thus, a limited effect. “We wanted to investigate whether using a specific population of neural cells would help increase the number of mature brain cells that the stem cell graft yields,” Dr. Wolfe explained.

The team began by harvesting NSCs from the brains of baby mice and used a process known as fluorescence activated cell sorting to identify cells with markers for CD15, a type of carbohydrate found on a cell’s surface that plays an important role in cell migration, adhesion and in the growth factor signaling involved in cell maintenance and differentiation.

Cells sorting allowed the scientists to achieve a population of cells in which 98 percent were CD15-positive. This process resulted in six times more CD15-positive cells than when cell sorting is not used. These cells were then differentiated in the lab into neurons, astrocytes and oligodendrocytes, which are types of cells found in the central nervous system (the brain and spinal cord). The team next tested both sorted and non-sorted neural cells by injecting them into baby mice. One week later, a time when the brain is still growing, they found that cells from both groups had populated the animals’ brains at a similar level.

“However, in the adult brain the survival of donor cells was significantly higher in the CD15-positive grafts than it was in the unsorted group,” Dr. Wolfe said. In addition, the engrafted stem cells had differentiated into all three types of neural cells with the CD15-positive ones showing a significant tendency to differentiate into oligodendrocytes. This type of cell plays a vital role in protecting neurons.

“This strategy may allow for better delivery of therapeutic cells to the brain,” said Anthony Atala, MD, editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine.

“The fact that the CD15-positive cells show a significant increase in oligodendrocytic differentiation suggests that they may be particularly useful for treating diseases involving white matter lesions.”

###

The full article, “Transplantation of CD15-enriched murine neural stem cells increases total engraftment and shifts differentiation towards the oligodendrocyte lineage,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine:

STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About AlphaMed Press:

Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), celebrating its 31th anniversary in 2012, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 18th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally-recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

Read the full story at http://www.prweb.com/releases/2013/5/prweb10739497.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Demand for Dental Care Drives Growth in the Dental Orthodontic Supplies Market, According to New Report by Global Industry Analysts, Inc.
2. Global Critical Care Market Will Reach $3.2 Billion in 2019 - Growth from Factor Concentrates, New Indications and Increasing Demand for Albumin in Asia-Pacific
3. Provillus Breakthrough Hair Regrowth Formula Works in a More Gender-Specific Manner
4. Bacteria in Babys Belly May Influence Growth, Study Says
5. Medical Device Companies Eke Out Growth In Tough Market, Finds Latest Kalorama Report
6. New SMB Cloud Market in the APAC Region 2012-2016 - SMB Cloud Industry Share, Size, Trends, Analysis, Growth And Forecast Report To 2016
7. SmartSearch Marketing, a B2B Search Marketing Agency, Adds Content Strategy Manager to Serve Rapid Client Growth
8. Time to tumor growth helps predict survival benefit of Bevacizumab for patients with metastatic colorectal cancer
9. Active Pharmaceutical Ingredients (API) Market in Europe Will Reach $38,255.67 Million By 2017- Pricing and Reimbursement Initiatives Supporting Generic Drug Growth
10. It Works! Global Named Top Company for Growth and Momentum
11. New HGH.com Web Site - Purchasing Human Growth Hormone and Bodybuilding Supplements Just Got Easier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
Breaking Medicine Technology: