Navigation Links
New Stanford model establishes guidelines for earlier cancer detection
Date:11/16/2011

gators linked these to additional models of tumor cell growth.

Tumors don't secrete drugs, but they can shed telltale molecules into surrounding tissue, from which those substances, known as biomarkers, diffuse into the blood. Some biomarkers may be made predominantly by tumor cells, while others exclusively by them. Either way, these substances can be measured in the blood as proxies for a tumor.

Some biomarkers are in wide use today. One is the well-known PSA, for prostate cancer. Another is CA125, for ovarian cancer. But these and other currently used blood tests for cancer biomarkers weren't specifically developed for early detection, and are generally more effective for relatively noninvasive monitoring of the progress of late-stage tumors or their response to treatment. (Rising blood levels of the substance indicate that the tumor is growing, while declining levels denote possible shrinkage.)

Both CA125 and PSA are also produced, albeit in smaller amounts, by healthy tissue, complicating efforts to detect cancer at an early stage when the tumor's output of the biomarker is relatively low.

The new mathematical model employs separate equations, each governing the movement of a biomarker from one compartment into the next. Into these equations, one can plug known values such as how fast a particular type of tumor grows, how much of the biomarker a tumor cell of this type sheds per hour and the minimum levels of the biomarker that must be present in the blood for a currently available assay to detect it.

As a test case, Gambhir and Hori chose CA125, a well-studied biomarker shed into blood by ovarian tumors. Ovarian cancer is a notorious example of a condition for which early detection would make a huge difference in survival outcomes.

CA125 is a protein made almost exclusively by ovarian tumor cells. The pharmacokinetics, metabolic fates, typical amounts secreted by an ovarian cell and other properties of CA1
'/>"/>

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Stanford team trains computer to evaluate breast cancer
2. Osteoarthritis results from inflammatory processes, not just wear and tear, Stanford study suggests
3. Caucasians who avoid sun exposure more likely to be vitamin D deficient, Stanford study suggests
4. Stanford researchers build transparent, super-stretchy skin-like sensor
5. Stanford brain imaging study shows physiological basis of dyslexia
6. Stanford researchers invent sutureless method for joining blood vessels
7. Stanford study draws connection between narcolepsy and influenza
8. Stanford discovery may eliminate potentially lethal side effect of stem cell therapy
9. Low blood pressure during dialysis increases risk of clots, according to Stanford-led study
10. Snooze you win? Its true for achieving hoop dreams, says Stanford study
11. Menthol cigarettes marketed in predatory pattern, Stanford study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... October 20, 2014 Do you ever ... Here comes a wonderful app Metassessor for teachers, specialists ... company helped its client “Intervention Development LLC” to ... app is designed for iOS 4.3 or later and ... app is optimized for iPhone 5. It is now ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, ... and GreenGeeks are the best Dedicated Server Hosting ... who want to buy high quality hosting and ... IT manager of Top10BestSEOHosting.com says, “We believe that ... for everyone. A lot of the global clients ...
(Date:10/19/2014)... UNITED NATIONS, New York (PRWEB) October 19, 2014 ... the United Nations Population Fund, welcomes news of a ... release of the more than 200 girls who were ... Girls. "These girls have languished in captivity long enough, ... their families, schools and communities," stated Dr. Osotimehin. , ...
(Date:10/19/2014)... working in the garment industry for decades, LunaDress’ dress specialists ... one of the company’s top designers, many ladies like prom ... add beauty to them. Chiffon floor length outfits are also ... selection of 2014 long prom dresses. , As a ... in over 20 popular designs. The company intends to meet ...
(Date:10/19/2014)... 20, 2014 Recently, Fancyflyingfox.com, an innovative ... clothes, has announced its latest designs of 2014 ... the new elegant outfits are offered with big discounts, ... order before October 30 can enjoy this special offer. ... marketing strategies, it has become one of the leading ...
Breaking Medicine News(10 mins):Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Fancyflyingfox.com Updates Its Website With New Mother Of The Bride Dresses For 2014 2
... parent,company, Team Finance LLC (the "Company") today announced ... The Company previously announced the decision to ... completed the disposal,of this business line during the ... with relevant accounting guidance, the results of the ...
... to increased odds of heart attack, death, study finds , , ... a doctor can hear when passing a stethoscope over a ... of heart attack and death from heart disease and stroke, ... carotid bruit (pronounced brew-ee) -- is caused by turbulent blood ...
... a mysterious illness that has resulted in the deaths of ... caves and mines in the northeastern U.S, bats exhibiting a ... , The U.S. Geological Survey (USGS) recently issued ... the U.S. to be on the lookout for the condition ...
... today announced that it has elected Joseph C. Scodari ... to have Joe Scodari join our Board of Directors.,He ... leader in the,pharmaceutical and biotechnology industries, and he has ... global healthcare businesses,",said Joe Herring, Covance chairman and CEO. ...
... defective cells in type 2 diabetics , , THURSDAY, May 8 ... fetal development appears to increase vulnerability to type 2 diabetes ... retardation (IUGR), which causes low birth weight in newborns, has ... other diseases when a child grows up. , And decreased ...
... It,s governed by a region of the brain that responds to ... belief that things should be divided fairly among members of a ... an emotion that,s built into the human brain. , That,s ... it better to give food to some hungry children while others ...
Cached Medicine News:Health News:Team Finance LLC Announces First Quarter 2008 Results 2Health News:Team Finance LLC Announces First Quarter 2008 Results 3Health News:Team Finance LLC Announces First Quarter 2008 Results 4Health News:Team Finance LLC Announces First Quarter 2008 Results 5Health News:Team Finance LLC Announces First Quarter 2008 Results 6Health News:Team Finance LLC Announces First Quarter 2008 Results 7Health News:Noise in Artery Could Warn of Heart Risk 2Health News:Dying bats in the Northeast remain a mystery 2Health News:Covance Elects Joseph C. Scodari to Company's Board of Directors 2Health News:Fetal Gene May Contribute to Diabetes Risk 2Health News:Fairness Is a Hard-Wired Emotion 2Health News:Fairness Is a Hard-Wired Emotion 3
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., ... therapeutic antibodies, today announced the appointment of ... Dr. Londei will lead the preclinical and clinical ... "We are pleased to welcome Dr. Londei ... Suria , President and Chief Executive Officer of ...
(Date:10/20/2014)... 20, 2014   Mary,s Medicinals today announced ... a 4-Star Sponsor of Operation Grow4Vets , a ... products, programs and services to assist them in living ... Key Facts: , An ever-increasing number of ... and effective treatment for pain, Post-traumatic Stress Disorder (PTSD) ...
(Date:10/19/2014)... SEATTLE, Wash. , Oct. 20, 2014 ... today that it will report its third quarter 2014 ... close of the U.S. financial markets. Following the announcement, ... conference call to discuss the results and provide a ... PDT). Access to the event can be obtained as ...
Breaking Medicine Technology:AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3CTI BioPharma to Report Third Quarter 2014 Financial Results on October 29, 2014 2
Heine Beta 200 Streak Retinoscope 2.5v...
Keeler Professional Combi Retinoscope with new slimline handle and lithium or dry cell option....
System, English (Continental cord), 230 VAC....
Micro-mini fiber optic light....
Medicine Products: