Navigation Links
New Spray Could Benefit Cystic Fibrosis Patients

Airways remained clear and moist in studies, researcher says

MONDAY, May 18 (HealthDay News) -- A new aerosol spray may help keep the airways of cystic fibrosis patients moist and clear, researchers say.

Using a special agent called GS-9411, the spray prevents sodium from being absorbed too quickly, which is a common problem for people with cystic fibrosis. The quick absorption of sodium from the surface of the airway causes their airways to dry, and allows mucous and bacteria to accumulate.

In tests on airway surface cells grown in a laboratory, GS-9411 helped the cells retain moisture for more than eight hours while tests on animals found the spray helped clear excessive mucus for at least four hours.

The findings were presented Sunday at the American Thoracic Society's annual international conference in San Diego.

"GS-9411 administered by aerosol can effectively increase airway surface liquid and enhance mucous clearance in an animal model," study author Andrew Hirsh, senior director of drug discovery and preclinical development for Parion Sciences, a pharmaceutical company, said in a news release. "The results demonstrate that GS-9411 warrants further investigation as a new drug therapy to decrease respiratory infection and improve pulmonary function."

In cystic fibrosis, a genetic defect causes the airway to absorb sodium, and therefore moisture, too quickly. When the airway is too dry, the body can't clear mucus, a key defense mechanism of the respiratory system, Hirsh said. This deficiency can cause cystic fibrosis patients to have chronic respiratory infection and impaired lung function, he explained.

"The potency and the length of time that the drug was effective in cells and in animal studies was an outstanding feature that distinguishes this compound from other agents," he said.

More information

The March of Dimes has more about cystic fibrosis.

-- Kevin McKeever

SOURCE: American Thoracic Society, news release, May 17, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Video: NASONEX(R) (Mometasone Furoate Monohydrate) Nasal Spray, 50 mcg* Teams Up With American Forests to Educate Nasal Allergy Sufferers and Help Improve Air Quality
2. Groundbreaking First Response Spray Now Available in Europe
3. Topical Spray Helped Men With Premature Ejaculation
4. Premature ejaculation spray enables men to last 6 times longer after penetration
5. Strativa Pharmaceuticals Acquires Worldwide Rights to Nascobal(R) (Cyanocobalamin, USP) Nasal Spray From QOL Medical
6. CSA Medical, Inc. Announces Launch of New Web Site for Spray Cryotherapy
7. Sinus Buster Pepper Nasal Spray Moves Into Rite Aid Drug Stores
8. Ocean Spray Shows Its Love for Heart Health with American Heart Association Partnership
9. Nose-spray vaccine against botulism effective in first tests
10. Ocean Spray(R) Announces Sugar-Free Drink Mixes - A Sweet Way for Dieters to Stick to Their Resolutions
11. Hairspray Exposure Ups Risk for Birth Defect in Sons
Post Your Comments:
Related Image:
New Spray Could Benefit Cystic Fibrosis Patients
(Date:11/30/2015)... , ... November 30, 2015 , ... ... – Kreithen”), one of the leading plastic surgery practices in Florida, is proud ... chosen to consult for surgical innovations giant Ethicon Inc., a Johnson & Johnson ...
(Date:11/30/2015)... ... November 30, 2015 , ... The successful filing of an Investigational New ... is so important to this key industry segment, Regis Technologies has decided to sponsor ... December 4th at 11am EST. , Federal law does not allow new drugs to ...
(Date:11/30/2015)... ... November 30, 2015 , ... Healthjump, Inc. announced ... a Healthcare IT consulting, development and support company. The purchase will expand the ... within DataTrade to extend the services currently provided by Healthjump. , ...
(Date:11/30/2015)... ... , ... GKhair & Tibolli team members and artists were excited and proud ... 8th and 9th at the Puerto Rico Convention Center, San Juan Puerto Rico. The ... of the line fashion journalists. The San Juan Beauty Show carries immense credibility among ...
(Date:11/30/2015)... Georgia (PRWEB) , ... November 30, 2015 , ... ... for healthcare professionals worldwide today released the results of a survey of educational ... East and Africa found a growing global demand for high quality online and ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... LONDON and BOSTON , ... to research and develop potential new medicines directed at ... multiple therapeutic areas. --> PFE ) to ... to 10 G protein-coupled receptor (GPCR) targets across multiple ... clinical-stage GPCR structure-guided drug discovery and development company and ...
(Date:11/30/2015)... Israel , Nov. 30, 2015  OticPharma, ... acquiring and developing innovative therapies for ear, nose, and ... Keith A. Katkin as chairman of the company,s ... chief executive officer for OticPharma, Ltd.  "Keith brings a ... he will be able to share this experience and ...
(Date:11/30/2015)... SHELTON, Connecticut , November 30, 2015 ... Kentucky Breast Care has entered into a ... women,s healthcare practice. This will allow Kentucky Breast Care ... and offer exceptional care for their patients. ... Kentucky Breast Care has entered into a ...
Breaking Medicine Technology: