Navigation Links
New Spray Could Benefit Cystic Fibrosis Patients
Date:5/18/2009

Airways remained clear and moist in studies, researcher says

MONDAY, May 18 (HealthDay News) -- A new aerosol spray may help keep the airways of cystic fibrosis patients moist and clear, researchers say.

Using a special agent called GS-9411, the spray prevents sodium from being absorbed too quickly, which is a common problem for people with cystic fibrosis. The quick absorption of sodium from the surface of the airway causes their airways to dry, and allows mucous and bacteria to accumulate.

In tests on airway surface cells grown in a laboratory, GS-9411 helped the cells retain moisture for more than eight hours while tests on animals found the spray helped clear excessive mucus for at least four hours.

The findings were presented Sunday at the American Thoracic Society's annual international conference in San Diego.

"GS-9411 administered by aerosol can effectively increase airway surface liquid and enhance mucous clearance in an animal model," study author Andrew Hirsh, senior director of drug discovery and preclinical development for Parion Sciences, a pharmaceutical company, said in a news release. "The results demonstrate that GS-9411 warrants further investigation as a new drug therapy to decrease respiratory infection and improve pulmonary function."

In cystic fibrosis, a genetic defect causes the airway to absorb sodium, and therefore moisture, too quickly. When the airway is too dry, the body can't clear mucus, a key defense mechanism of the respiratory system, Hirsh said. This deficiency can cause cystic fibrosis patients to have chronic respiratory infection and impaired lung function, he explained.

"The potency and the length of time that the drug was effective in cells and in animal studies was an outstanding feature that distinguishes this compound from other agents," he said.

More information

The March of Dimes has more about cystic fibrosis.



-- Kevin McKeever



SOURCE: American Thoracic Society, news release, May 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Video: NASONEX(R) (Mometasone Furoate Monohydrate) Nasal Spray, 50 mcg* Teams Up With American Forests to Educate Nasal Allergy Sufferers and Help Improve Air Quality
2. Groundbreaking First Response Spray Now Available in Europe
3. Topical Spray Helped Men With Premature Ejaculation
4. Premature ejaculation spray enables men to last 6 times longer after penetration
5. Strativa Pharmaceuticals Acquires Worldwide Rights to Nascobal(R) (Cyanocobalamin, USP) Nasal Spray From QOL Medical
6. CSA Medical, Inc. Announces Launch of New Web Site for Spray Cryotherapy
7. Sinus Buster Pepper Nasal Spray Moves Into Rite Aid Drug Stores
8. Ocean Spray Shows Its Love for Heart Health with American Heart Association Partnership
9. Nose-spray vaccine against botulism effective in first tests
10. Ocean Spray(R) Announces Sugar-Free Drink Mixes - A Sweet Way for Dieters to Stick to Their Resolutions
11. Hairspray Exposure Ups Risk for Birth Defect in Sons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New Spray Could Benefit Cystic Fibrosis Patients
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: