Navigation Links
New Source of Heart Stem Cells Found
Date:6/23/2008

Expression of particular gene can help regenerate multiple tissue types

MONDAY, June 23 (HealthDay News) -- Newly-identified stem cells located on the surface of the heart give rise to heart muscle cells, say researchers at Children's Hospital Boston.

They believe the finding may lead to ways to regenerate injured heart tissue.

In previous research, the Children's team found that two types of stem cells (progenitors) marked by activity of the genes Nkx2-5 and IsI1 form many components of the heart. In this new study, the team identified another progenitor, marked by expression of a gene called Wt1, that gives rise to heart muscle cells.

The findings were published online June 22 in the journal Nature.

"There's a lot of interest in finding places to obtain new cardiomyocytes (heart muscle cells), because in heart failure, you lose cardiomyocytes, so the only way to reverse heart failure is to make more of these cells," study senior investigator Dr. William Pu, a pediatric cardiologist, said in a prepared statement.

Although it was known that cells on the surface of the heart (epicardium) give rise to smooth muscle and endothelial cells that line blood vessels, this finding that epicardial cells might turn into cardiomyocytes came as a surprise.

"I couldn't believe it at first, myself," Pu said.

Not only do the progenitor cells marked by Wt1 expression differentiate into cardiomyocytes, they also turn into smooth muscle cells, endothelial cells and fibroblasts (found in connective tissue).

"If you're going to regenerate a tissue, you need to regenerate the whole tissue, not just the cardiomyocytes. This progenitor population contains all the potential to regenerate multiple tissue types within the heart," Pu said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart failure.



-- Robert Preidt



SOURCE: Children's Hosptial Boston, news release, June 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top
2. Psoriasis Cure Now offers Back to School Resources for Parents of Children with Psoriasis
3. ADDAS Awareness Campaign Offers Resources and Education to Adults Living with AD/HD and Professionals Working With Them
4. MassMutual Promotes Debra Palermino to Senior Vice President of Human Resources
5. AWWA, National Association of Water and Sanitation of Mexico, Agree to Share Expertise and Resources for Improved Water Supply
6. Briefing on a new Web resource to address global drinking water crisis
7. Regional Center of Orange County Expands Family Support Resources to Meet Growing Needs
8. Recovery Resources Collaborates with Two Nonprofit Agencies for Children of Alcoholics Outreach Program
9. MEDEX Global Group & Harvard Medical International Join Forces to Create the Most Comprehensive Health Information Resource for International Travelers
10. Office-Based Medical Treatment and Internet Resources Are Potential Solution to Rising Painkiller Misuse Among Teens, Young Adults
11. Broker a Suite of Research & Advisory Services to Enhance Human Resources
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Ellevate Network, ... in business to advocate for action towards gender equality at their inaugural Summit in ... around the globe, and reached a social audience of over 3 million. To watch ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... -- Commended for their devotion to personalized service, SMP Pharmacy Solutions ... in the South Florida Business Journal,s 50 Fastest-Growing Companies, and ... the national specialty pharmacy has found its niche.  To that ... be honored by SFBJ as the 2017 Power Leader in ... receive his award in October, Bardisa said of the three ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
Breaking Medicine Technology: