Navigation Links
New Source of Heart Stem Cells Found
Date:6/23/2008

Expression of particular gene can help regenerate multiple tissue types

MONDAY, June 23 (HealthDay News) -- Newly-identified stem cells located on the surface of the heart give rise to heart muscle cells, say researchers at Children's Hospital Boston.

They believe the finding may lead to ways to regenerate injured heart tissue.

In previous research, the Children's team found that two types of stem cells (progenitors) marked by activity of the genes Nkx2-5 and IsI1 form many components of the heart. In this new study, the team identified another progenitor, marked by expression of a gene called Wt1, that gives rise to heart muscle cells.

The findings were published online June 22 in the journal Nature.

"There's a lot of interest in finding places to obtain new cardiomyocytes (heart muscle cells), because in heart failure, you lose cardiomyocytes, so the only way to reverse heart failure is to make more of these cells," study senior investigator Dr. William Pu, a pediatric cardiologist, said in a prepared statement.

Although it was known that cells on the surface of the heart (epicardium) give rise to smooth muscle and endothelial cells that line blood vessels, this finding that epicardial cells might turn into cardiomyocytes came as a surprise.

"I couldn't believe it at first, myself," Pu said.

Not only do the progenitor cells marked by Wt1 expression differentiate into cardiomyocytes, they also turn into smooth muscle cells, endothelial cells and fibroblasts (found in connective tissue).

"If you're going to regenerate a tissue, you need to regenerate the whole tissue, not just the cardiomyocytes. This progenitor population contains all the potential to regenerate multiple tissue types within the heart," Pu said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart failure.



-- Robert Preidt



SOURCE: Children's Hosptial Boston, news release, June 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top
2. Psoriasis Cure Now offers Back to School Resources for Parents of Children with Psoriasis
3. ADDAS Awareness Campaign Offers Resources and Education to Adults Living with AD/HD and Professionals Working With Them
4. MassMutual Promotes Debra Palermino to Senior Vice President of Human Resources
5. AWWA, National Association of Water and Sanitation of Mexico, Agree to Share Expertise and Resources for Improved Water Supply
6. Briefing on a new Web resource to address global drinking water crisis
7. Regional Center of Orange County Expands Family Support Resources to Meet Growing Needs
8. Recovery Resources Collaborates with Two Nonprofit Agencies for Children of Alcoholics Outreach Program
9. MEDEX Global Group & Harvard Medical International Join Forces to Create the Most Comprehensive Health Information Resource for International Travelers
10. Office-Based Medical Treatment and Internet Resources Are Potential Solution to Rising Painkiller Misuse Among Teens, Young Adults
11. Broker a Suite of Research & Advisory Services to Enhance Human Resources
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... ... Leading dental clinicians, Drs. Ashlyn Price, Autumn Mayers and Ron Adelman, now ... With advanced digital images and modeling capabilities, the dentists identify all of the structures ... health for those who are missing teeth in Midlothian, VA. , In ...
(Date:6/20/2017)... ... June 20, 2017 , ... As a leading dental practice, ... between stroke and gum disease. Those with bleeding gums in Vancouver, BC, may be ... condition can lead to heart disease, stroke and diabetes. Drs. Parviz Roshan, Siamak Tehrani ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... (AHN) Jefferson Hospital is providing physicians with advanced capabilities for diagnosing and treating ... than traditional MRIs, enabling doctors to get a more accurate look inside the ...
(Date:6/20/2017)... Linda, Ca (PRWEB) , ... June 20, 2017 ... ... of alternative polyA sites. To understand their regulatory principles, the research team developed ... mRNA-Seq, iCLIP and RNA motif analyses. This reveals at nucleotide resolution the ‘RNA ...
(Date:6/20/2017)... ... 20, 2017 , ... Uniform Advantage (UA), a multi-channel retailer of ... to create tailored looks and athleisure-inspired outfits. UA Flex fabric is breathable, wrinkle resistant ... , With trendy looks hitting the medical community, UA Flex is for the medical ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... 2017 DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... that it will be presenting at the 7th annual LD Micro ... Erez Raphael , CEO, of DarioHealth will be giving the presentation ... on June 6th & 7th, 2017 at the Luxe Sunset Bel ... micro-cap space. About LD Micro ...
(Date:5/26/2017)... DUBLIN , May 26, 2017  Endo International plc ... Campanelli , President and CEO, will represent the Company in ... Global Healthcare Conference on Tuesday, June 13, 2017 at 10:40 ... held at Terranea Resort in Rancho Palos Verdes, ... archive for the event will be available on the Company,s ...
(Date:5/22/2017)... , May 22, 2017  Lilac Corp, ... Gene-Eden-VIR/Novirin, announces the launch of a new ... the results of a clinical study that showed ... treatment with Gene-Eden-VIR/Novirin in individuals suffering from HPV ... note that there are no other treatments that ...
Breaking Medicine Technology: