Navigation Links
New Scientific Evidence Suggests Humans Resistant to Phthalate Effect on Lab Rodents
Date:6/25/2009

Sharpe et al. Study Finds Dose High Enough to Cause Adverse Effect in Rats and Mice Has No Effect in Male Marmosets

ARLINGTON, Va., June 25 /PRNewswire-USNewswire/ -- The American Chemistry Council (ACC) today announced that strong new evidence has emerged that phthalates may not affect the reproductive development of humans, as opposed to the effects seen in some rats and mice. A study by McKinnell et al. shows no reproductive effects from phthalates in marmosets. In research conducted in the Edinburgh, Scotland, laboratory of Dr. Richard Sharpe, doses of a phthalate in concentrations high enough to cause adverse effects in the reproductive systems of male rodents were given to pregnant marmosets monkeys--which are primates-- and thus much more similar to humans than are rodents. Males born to the pregnant monkeys showed no gross testicular structural damage, and no other effects on the reproductive system development, male hormone levels, no hypospadias, which are malformations of the urethra in males, or on their number of germ cells, all the way through to adulthood. The researchers also separately dosed infant male marmosets, and detected no significant effects on their germ cells as they developed.

ACC Managing Director, Chris Bryant, issued the following statement:

"This new research adds significantly to earlier work, and increases the overall weight of scientific evidence that suggests primates, which include humans, are more resistant to the effects of phthalates than are lab rodents. Japanese research published in 2006 by Tomonari et al. showed that huge doses of a phthalate that can affect rodents showed no testicular effects in developing infant marmosets. It is worth noting that there are significant differences even between rats and mice in the way they react to phthalates. So it is not at all surprising that there would be significant differences between rodents and primates."

http://www.americanchemistry.com

The American Chemistry Council (ACC) represents the leading companies engaged in the business of chemistry. ACC members apply the science of chemistry to make innovative products and services that make people's lives better, healthier and safer. ACC is committed to improved environmental, health and safety performance through Responsible Care(R), common sense advocacy designed to address major public policy issues, and health and environmental research and product testing. The business of chemistry is a $689 billion enterprise and a key element of the nation's economy. It is one of the nation's largest exporters, accounting for ten cents out of every dollar in U.S. exports. Chemistry companies are among the largest investors in research and development. Safety and security have always been primary concerns of ACC members, and they have intensified their efforts, working closely with government agencies to improve security and to defend against any threat to the nation's critical infrastructure.


'/>"/>
SOURCE American Chemistry Council
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Boston Scientific Announces Retirement of Jim Tobin and Appointment of Ray Elliott as New President and CEO
2. Milestone Scientific Expands Global Sales Strategy to Enhance Penetration of International Dental Markets
3. Breaking medical and scientific news in angioplasty to be presented in San Francisco at TCT 2009
4. Thomson Reuters Partners with Research4Life to Bring Scientific Research Information Resources to Developing Countries Around the World
5. Boston Scientifics Urology/Gynecology Products Featured in Studies at International Urogynecological Association Annual Meeting
6. Scientific Study Makes it Possible to Measure Connection Between People
7. Statement by American Dietetic Association Supporting Scientifically Valid, Informative Restaurant Labeling as Part of Health Reform
8. Press Releases on BPA Studies By-Pass Scientific Process
9. Entest BioMedical Inc. Adds Former National Cancer Institute Researcher to Scientific Advisory Board With Focus on Stem Cell Cancer Patient Therapies
10. Fora Care Inc. to Launch Cost-Effective Solution for Diabetes Care at ADA 69th Scientific Sessions
11. Patriot Scientific Corporation Announces Patriot Data Solutions Group
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... A revolution is underway. Brooklyn-based company, ... for the millions of people who require these medical transport services annually. ... the use of technology. Now, SmartEMS has put forth an industry-changing app that ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
Breaking Medicine Technology: