Navigation Links
New Research from Mount Sinai on Alcohol Could Spur Development of Antidote

New York, NY (PRWEB) October 23, 2013

Scientists now understand how alcohol alters the activity of brain proteins. Ethanol, the alcohol found in beer, wine, and spirits, impairs communication between nerve cells in the brain, affecting our perception and behavior. Paul A. Slesinger, PhD, Professor in the Arthur M. Fishberg Department of Neuroscience at the Icahn School of Medicine at Mount Sinai and Karthik Bodhinathan, PhD, postdoctoral fellow at the Salk Institute for Biological Studies, La Jolla, CA, examined the physical site for ethanol in a brain ion channel, a protein that controls electrical activity of neurons. Results from their study, published online Oct. 21 in the Proceedings of the National Academy of Sciences, suggest that scientists have a clearer view of ethanol’s action and potentially how to interfere with it.

“Ethanol is an amazingly simple drug chemically, yet scientists have been mystified by how a small molecule exerts such profound effects on the function of brain proteins,” said Dr. Slesinger.

In previous work, Dr. Slesinger identified a trigger site for ethanol located with a brain potassium ion channel, which controls electrical activity for proper nerve cell communication. This new research builds on that work, describing for the first time, used a unique technique of ‘alcohol tagging’ to decipher the molecular mechanism underlying ethanol activation of this brain channel protein. In the new paper, “we also discovered a molecule commonly found in the cell’s membrane that can directly influence how ethanol activates these brain potassium channels,” said Dr. Bodhinathan.

“Now that we know the way ethanol binds to these brain proteins, it may be possible in the future to design drugs that take advantage of the chemical features of this alcohol site,” said Dr. Slesinger. “Designing drugs as an antidote might prove a viable intervention.”

Drs. Slesinger and Bodhinathan believe that their work may extend to other alcohol-sensitive proteins, opening the door to a whole new direction for developing alcohol-selective therapeutics in the treatment of alcoholism and addiction.”

This work was supported by the American Heart Association, the National Institute on Alcohol Abuse and Alcoholism, and the National Institute on Drug Abuse.

About the Mount Sinai Health System
The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven member hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.

The System includes approximately 6,600 primary and specialty care physicians, 12-minority-owned free-standing ambulatory surgery centers, over 45 ambulatory practices throughout the five boroughs of New York City, Westchester, and Long Island, as well as 31 affiliated community health centers. Physicians are affiliated with the Icahn School of Medicine at Mount Sinai, which is ranked among the top 20 medical schools both in National Institutes of Health funding and by U.S. News & World Report.

For more information, visit
Find Mount Sinai on:
Twitter @mountsinainyc

Read the full story at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Neurotoxin effectively relieves bone cancer pain in dogs, Penn researchers find
2. Bradley Hasbro Childrens Research Center launches food allergy video game trial
3. Global Nitrogenous Fertilizer Market to 2017 is the New Research Report Available with
4. Fred Hutchinson Cancer Research Center opens HIV-vaccine lab in South Africa
5. Postherpetic Neuralgia Market (PHN) Analysis and 2022 Forecasts in New Research Report at
6. Research and Development Forecast of High Voltage DC Power Supply in China, 2013-2017
7. Research and Forecast of China’s Dietary Supplement (Health Food) Industry, 2013-2017
8. Gates Foundation and Mayo Clinic Experts to Address Vaccine Research in the 21st Century
9. Redressing Past Wrongs: Changing the Common Rule to Increase Minority Voices in Research
10. Medical & Surgical Equipment Repair Procurement Research Report Now Available from IBISWorld
11. Mount Sinai Researchers Find Value -- and Limitations -- of Patient Assistance Programs for Women with Breast Cancer
Post Your Comments:
(Date:11/24/2015)... Texas (PRWEB) , ... November 24, 2015 , ... Charitable ... all charitable donations are made in the last five weeks of the year totalling ... was created in 2012 to connect the nation’s charities with those individuals who want ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... national leaders when it comes to several aspects of orthopedic care. They have ... replacements, orthopedic surgeries and general orthopedic care. , Becker's Hospital Review selected ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... In response ... growing epidemic as deaths from prescription opioids in the United States grew 400 percent ... In 2013 alone, opioids were involved in 37 percent of all fatal drug overdoses. ...
(Date:11/24/2015)... ... , ... Serenity Point Rehabilitation, a holistic treatment center for substance abuse located ... the staff members at their recovery center. The videos highlight some of the various ... the things that make their recovery program so unique. , “Making the decision to ...
(Date:11/24/2015)... ... November 24, 2015 , ... Chiropractic student Katie Benson received ... in Overland Park, Kansas. Benson, a fifth-trimester student in the university’s College of ... on October 16. , “Katie is very excited and greatly appreciative to receive ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... NEW DELHI , November 25, 2015 ... fear invoked due to repeated failure of IVF cycles. ... Rani Bhatia was totally dejected and had lost all hopes that ... the first Indian miracle child conceived after failure of ... to abroad (UK) before they decided to take one last ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
(Date:11/24/2015)... November 2015 Avery Biomedical Devices ... ist erfreut, die Berufung von Anders Jonzon, ... zu können.   ... Foto -   ... 1984-1986 war er Fellow des Cardiovascular Institute ...
Breaking Medicine Technology: