Navigation Links
New Research from Mount Sinai on Alcohol Could Spur Development of Antidote

New York, NY (PRWEB) October 23, 2013

Scientists now understand how alcohol alters the activity of brain proteins. Ethanol, the alcohol found in beer, wine, and spirits, impairs communication between nerve cells in the brain, affecting our perception and behavior. Paul A. Slesinger, PhD, Professor in the Arthur M. Fishberg Department of Neuroscience at the Icahn School of Medicine at Mount Sinai and Karthik Bodhinathan, PhD, postdoctoral fellow at the Salk Institute for Biological Studies, La Jolla, CA, examined the physical site for ethanol in a brain ion channel, a protein that controls electrical activity of neurons. Results from their study, published online Oct. 21 in the Proceedings of the National Academy of Sciences, suggest that scientists have a clearer view of ethanol’s action and potentially how to interfere with it.

“Ethanol is an amazingly simple drug chemically, yet scientists have been mystified by how a small molecule exerts such profound effects on the function of brain proteins,” said Dr. Slesinger.

In previous work, Dr. Slesinger identified a trigger site for ethanol located with a brain potassium ion channel, which controls electrical activity for proper nerve cell communication. This new research builds on that work, describing for the first time, used a unique technique of ‘alcohol tagging’ to decipher the molecular mechanism underlying ethanol activation of this brain channel protein. In the new paper, “we also discovered a molecule commonly found in the cell’s membrane that can directly influence how ethanol activates these brain potassium channels,” said Dr. Bodhinathan.

“Now that we know the way ethanol binds to these brain proteins, it may be possible in the future to design drugs that take advantage of the chemical features of this alcohol site,” said Dr. Slesinger. “Designing drugs as an antidote might prove a viable intervention.”

Drs. Slesinger and Bodhinathan believe that their work may extend to other alcohol-sensitive proteins, opening the door to a whole new direction for developing alcohol-selective therapeutics in the treatment of alcoholism and addiction.”

This work was supported by the American Heart Association, the National Institute on Alcohol Abuse and Alcoholism, and the National Institute on Drug Abuse.

About the Mount Sinai Health System
The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven member hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.

The System includes approximately 6,600 primary and specialty care physicians, 12-minority-owned free-standing ambulatory surgery centers, over 45 ambulatory practices throughout the five boroughs of New York City, Westchester, and Long Island, as well as 31 affiliated community health centers. Physicians are affiliated with the Icahn School of Medicine at Mount Sinai, which is ranked among the top 20 medical schools both in National Institutes of Health funding and by U.S. News & World Report.

For more information, visit
Find Mount Sinai on:
Twitter @mountsinainyc

Read the full story at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Neurotoxin effectively relieves bone cancer pain in dogs, Penn researchers find
2. Bradley Hasbro Childrens Research Center launches food allergy video game trial
3. Global Nitrogenous Fertilizer Market to 2017 is the New Research Report Available with
4. Fred Hutchinson Cancer Research Center opens HIV-vaccine lab in South Africa
5. Postherpetic Neuralgia Market (PHN) Analysis and 2022 Forecasts in New Research Report at
6. Research and Development Forecast of High Voltage DC Power Supply in China, 2013-2017
7. Research and Forecast of China’s Dietary Supplement (Health Food) Industry, 2013-2017
8. Gates Foundation and Mayo Clinic Experts to Address Vaccine Research in the 21st Century
9. Redressing Past Wrongs: Changing the Common Rule to Increase Minority Voices in Research
10. Medical & Surgical Equipment Repair Procurement Research Report Now Available from IBISWorld
11. Mount Sinai Researchers Find Value -- and Limitations -- of Patient Assistance Programs for Women with Breast Cancer
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... Today, Mothers Against Drunk ... roadways has dropped below 10,000 for the first time since 2011. In 2014, there ... According to data released by the National Highway Traffic Safety Administration (NHTSA), 32,675 people ...
(Date:11/25/2015)... ... ... An unlikely combination of recycled plastic shopping bags in ... to have a more dignified and comfortable night’s sleep. , Residents of Friendship ... bags into sleeping mats for the homeless. The project, according to Jeannette ...
(Date:11/25/2015)... CA (PRWEB) , ... November 25, 2015 , ... ... bunion treatment, is offering lower prices in an early celebration of the early ... the promotional price of $29.95 each (normally $33.95 ea). Black Friday promotional pricing ...
(Date:11/24/2015)... ... November 24, 2015 , ... Young patients with a wide variety ... Wolfman and Dr. Kedar S. Lele, who are pediatric dentists in Tucson, AZ ... the WaterLase iPlus 2.0™ system causes minimal discomfort and bleeding to the patient during ...
(Date:11/24/2015)... ... , ... DMG Productions announced that they will feature Aphria, Inc., in an ... Channel. Dates and show times TBA. , Aphria, Inc., is a publicly traded company ... and supplying medical marijuana pursuant to the Marijuana for Medical Purposes Regulations (the “MMPR”). ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , November 25, 2015 The ... to repeated failure of IVF cycles. After failure of ... dejected and had lost all hopes that she would be able to ... miracle child conceived after failure of over 15 IVF ... (UK) before they decided to take one last attempt with Gaudium ...
(Date:11/24/2015)... CARLOS, Calif. , Nov. 24, 2015 ... a leader in non-invasive genetic testing and ... announced that it will present at the ... in New York on Wednesday, December 2, 2015 at 1:00 p.m. ET.  Matthew ... the Company,s financial results, business activities and ...
(Date:11/24/2015)... TX and VANCOUVER, Nov. 24, 2015 /PRNewswire/ - ... NASDAQ: EPIX ) announced today that the first ... study of EPI-506 as a treatment for metastatic castration-resistant ... and Canada.  --> ... --> In the Phase 1/2 clinical trial, ESSA ...
Breaking Medicine Technology: