Navigation Links
New Research from Mount Sinai on Alcohol Could Spur Development of Antidote
Date:10/23/2013

New York, NY (PRWEB) October 23, 2013

Scientists now understand how alcohol alters the activity of brain proteins. Ethanol, the alcohol found in beer, wine, and spirits, impairs communication between nerve cells in the brain, affecting our perception and behavior. Paul A. Slesinger, PhD, Professor in the Arthur M. Fishberg Department of Neuroscience at the Icahn School of Medicine at Mount Sinai and Karthik Bodhinathan, PhD, postdoctoral fellow at the Salk Institute for Biological Studies, La Jolla, CA, examined the physical site for ethanol in a brain ion channel, a protein that controls electrical activity of neurons. Results from their study, published online Oct. 21 in the Proceedings of the National Academy of Sciences, suggest that scientists have a clearer view of ethanol’s action and potentially how to interfere with it.

“Ethanol is an amazingly simple drug chemically, yet scientists have been mystified by how a small molecule exerts such profound effects on the function of brain proteins,” said Dr. Slesinger.

In previous work, Dr. Slesinger identified a trigger site for ethanol located with a brain potassium ion channel, which controls electrical activity for proper nerve cell communication. This new research builds on that work, describing for the first time, used a unique technique of ‘alcohol tagging’ to decipher the molecular mechanism underlying ethanol activation of this brain channel protein. In the new paper, “we also discovered a molecule commonly found in the cell’s membrane that can directly influence how ethanol activates these brain potassium channels,” said Dr. Bodhinathan.

“Now that we know the way ethanol binds to these brain proteins, it may be possible in the future to design drugs that take advantage of the chemical features of this alcohol site,” said Dr. Slesinger. “Designing drugs as an antidote might prove a viable intervention.”

Drs. Slesinger and Bodhinathan believe that their work may extend to other alcohol-sensitive proteins, opening the door to a whole new direction for developing alcohol-selective therapeutics in the treatment of alcoholism and addiction.”

This work was supported by the American Heart Association, the National Institute on Alcohol Abuse and Alcoholism, and the National Institute on Drug Abuse.

About the Mount Sinai Health System
The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven member hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.

The System includes approximately 6,600 primary and specialty care physicians, 12-minority-owned free-standing ambulatory surgery centers, over 45 ambulatory practices throughout the five boroughs of New York City, Westchester, and Long Island, as well as 31 affiliated community health centers. Physicians are affiliated with the Icahn School of Medicine at Mount Sinai, which is ranked among the top 20 medical schools both in National Institutes of Health funding and by U.S. News & World Report.

For more information, visit http://www.mountsinai.org.
Find Mount Sinai on:
Facebook: http://www.facebook.com/mountsinainyc
Twitter @mountsinainyc
YouTube: http://www.youtube.com/mountsinainy

Read the full story at http://www.prweb.com/releases/2013/10/prweb11261461.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Neurotoxin effectively relieves bone cancer pain in dogs, Penn researchers find
2. Bradley Hasbro Childrens Research Center launches food allergy video game trial
3. Global Nitrogenous Fertilizer Market to 2017 is the New Research Report Available with ReportsnReports.com
4. Fred Hutchinson Cancer Research Center opens HIV-vaccine lab in South Africa
5. Postherpetic Neuralgia Market (PHN) Analysis and 2022 Forecasts in New Research Report at RnRMarketResearch.com
6. Research and Development Forecast of High Voltage DC Power Supply in China, 2013-2017
7. Research and Forecast of China’s Dietary Supplement (Health Food) Industry, 2013-2017
8. Gates Foundation and Mayo Clinic Experts to Address Vaccine Research in the 21st Century
9. Redressing Past Wrongs: Changing the Common Rule to Increase Minority Voices in Research
10. Medical & Surgical Equipment Repair Procurement Research Report Now Available from IBISWorld
11. Mount Sinai Researchers Find Value -- and Limitations -- of Patient Assistance Programs for Women with Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... 19, 2017 , ... DMG Productions, producers of the award ... an upcoming episode, slated to air fourth quarter 2017. Check your local listings ... a company committed to supporting dentistry using the most technologically advanced restorative materials ...
(Date:8/19/2017)... (PRWEB) , ... August 19, 2017 , ... Curl Keeper® ... of NaturallyCurly.com® The Curl Leaders, Editors’ Choice 2017 Award for the second year in ... for hair stylists and curlies alike was voted Best Moisturizer for Type 2 Wavies ...
(Date:8/19/2017)... ... August 19, 2017 , ... “Congratulations! It's A Boy! God’s Gift: ... both their parents and God. “Congratulations! It's A Boy! God’s Gift: A Story of ... from Long Island, New York. , Published by Christian Faith Publishing, Dale Anthony and ...
(Date:8/18/2017)... NY (PRWEB) , ... August 18, 2017 , ... ... of “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the ... available for individuals with hearing impairments and shares the latest innovations in hearing ...
(Date:8/18/2017)... VA (PRWEB) , ... August 18, 2017 , ... ... asset protection services and financial consultations to communities throughout the greater DC region, ... K9 with the goal of rescuing local animals and training them to be ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... Aug. 2, 2017 CaryRx, a next-generation full-service pharmacy, ... service for patients in the Washington D.C. ... pharmacy by providing delivery of medications through the convenience of ... delivery or delivered within one hour to any location in ... to bring this invaluable service to Washington D.C. ...
(Date:7/28/2017)... July 28, 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") ... third quarter ended June 30, 2017, and updated its ... For the fiscal third quarter, Hill-Rom ... $0.68 per diluted share in the prior-year period. These ... $0.39 per diluted share primarily related to the non-cash ...
(Date:7/26/2017)... 2017  Radium Medical Aesthetics, a leading medical aesthetic clinic in ... by effectively addressing several skin conditions from the inside. ... and more fragile. The skin becomes more transparent due to the ... harmful UV rays from the sun contributes to aging skin, causing ... ...
Breaking Medicine Technology: