New Research Will Benefit Four Million Americans Suffering from Chronic Fatigu... (demonstrated the significance of altered...)

New Research Will Benefit Four Million Americans Suffering from Chronic Fatigue Syndrome

Date:12/3/2008

demonstrated the significance of altered gastrointestinal bacteria in illnesses like HIV, diabetes, Crohn's disease, inflammatory bowel disease and ulcerative colitis. Shukla theorizes that CFS patients also have an imbalance of good and bad intestinal bacteria, resulting in enhanced intestinal permeability-called leaky gut-allowing bacteria to move across the protective intestinal barrier and causing chronic inflammation and immune activation in CFS patients. This study will contribute to our understanding of the relationship between the human microbiome and CFS. It may also lead to new treatment options, including the use of probiotics.

-- Dikoma Shungu, PhD, of Weill Medical College of Cornell University, who will use a brain scanning technique called magnetic resonance spectroscopy to confirm earlier findings that brain fluid of CFS patients contains significantly elevated levels of lactate, a substance important in metabolism. Shungu's team will also investigate the reason for this phenomenon, exploring whether lactate levels are higher in CFS patients because their brains contain high levels of toxic compounds that cause a condition called oxidative stress (which could implicate chronic inflammation), or because mitochondrial dysfunction is causing malfunctions in the production of brain energy. If this study is successful, brain lactate levels could provide an objective diagnostic biomarker for CFS.

The Accelerate CFS Research Initiative was made possible by the successful completion of a yearlong, million-dollar fundraising campaign, the largest research campaign for CFS to date in the United States. The CFIDS Association has funded more than $5.4 million in CFS research since 1987, making it second only to the federal government in CFS research spending.

"This was a real grassroots campaign, with most contributions coming not from major corporations or foundations, but from ordinary
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