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New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard-To-Treat Forms of Blood Cancer
Date:12/5/2009

, and complete remission rates (20 percent for VMP and 27 percent for VTP), but there was a clear difference in the toxicity profile of each group. In the VMP regimen there was a higher incidence of neutropenia (abnormally low count of white blood cells) and infections, but VTP resulted in the development of cardiac toxicity. The frequency of grade 3-4 peripheral neuropathy (PN) was 5 percent in the VMP group. Maintenance therapy with either VT or VP also markedly improved the quality of patient responses with a good safety profile, increasing complete response from 23 percent up to 42 percent, with no significant differences in response rates between the VT and VP treatment arms. In addition, both maintenance regimens resulted in an acceptable toxicity profile.

"Melphalan with prednisone has been the gold standard for the treatment of elderly multiple myeloma patients for the past 40 years, but novel combination therapies have emerged as superior options," said lead author Maria-Victoria Mateos, M.D., Ph.D., Attending Physician, Hematology Department at the Hospital Universitario de Salamanca in Spain. "In this study, we demonstrate that the combination of a reduced dosage for induction therapy followed by maintenance therapy may be a novel approach for treating this patient population."

Dr. Mateos will present this study at the Plenary Scientific Session on Sunday, December 6, at 2:30 p.m. in Hall F.

(1) Cleveland Clinic. Education: Prevalence and Incidence of Multiple Myeloma. Available at: http://my.clevelandclinic.org/myeloma/education/multiple_myeloma.aspx. Accessed November 20, 2009.

Psychological Correlates of Having Advance Care Planning in Patients With Hematological Malignancies [Abstract #72]

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SOURCE American Society of Hematology
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