Navigation Links
New Questions Raised About Lung Cancer Screening

Impartial Audit of Research Data Is Needed, Says Editor of "The Oncologist"

DURHAM, N.C., Oct. 1 /PRNewswire/ -- In response to new concerns about a study supporting the use of computed tomography (CT) screening to detect early-stage lung cancer in smokers and other people at risk, the Editor-in-Chief of "The Oncologist" has called for an independent audit of the research data.

(Logo: )

" ... the results of this key lung cancer prevention trial, heralded as evidence for the value of CT screening for lung cancer, have become increasingly ambiguous, a situation that can be dispelled only by auditing the trial," writes Dr. Bruce A. Chabner in an editorial.

Controversy has emerged regarding the International Early Lung Cancer Action Project (I-ELCAP) study, originally published in The New England Journal of Medicine in 2006. Lead researcher Dr. Claudia Henschke of Weill Medical College of Cornell University, New York, concluded that annual CT screening improves the chances of survival for patients with early-stage lung cancer.

Dr. Henschke believes her findings support annual CT scans for early detection of lung cancer in people at increased risk -- especially smokers. She has stood by her conclusions in the face of controversies regarding errors in patient enrollment, her undisclosed relationship with a major CT manufacturer, and the revelation that the study was partially funded by a tobacco company.

Dr. Chabner's call for an audit is prompted by a letter to the editor by Dr. Peter B. Bach of Memorial Sloan-Kettering Cancer Center, New York, also published by "The Oncologist." Dr. Bach points out an apparent irregularity in the way the I-ELCAP researchers calculated the survival benefit of CT screening. Specifically, while the original 2006 paper included data on eight "untreated subjects" who died of lung cancer, subsequent reports have included thirteen such patients.

Dr. Bach also raises concerns regarding the follow-up for some of the patients, noting that it was a virtual statistical impossibility that Henschke had the findings that she published. Dr. Bach comments, "I am concerned that there may have been an error during the analysis of the trial, such that the apparent benefit of screening appeared larger than it is."

In a published reply, Dr. Henschke writes that the discrepancy occurred because some patients were originally "misclassified," and that this error was perpetuated in follow-up analyses.

Dr. Chabner has previously urged a re-evaluation of the I-ELCAP data, and reiterates his call in response to the new concerns. He writes, "The bond that clinical investigators make with cancer patients who volunteer their enrollment is sacred ... Given the confusion that reigns, only with a thorough, complete, and impartial audit can this bond, the cornerstone of clinical research, be restored and preserved."

Dr. Thomas J. Lynch, Director of the Center for Thoracic Cancers at Massachusetts General Hospital, agrees that an independent audit is needed. "Finding out if screening CT scans save lives from lung cancer is of urgent importance," he comments. "Millions of ex-smokers await guidance on the use of this technology and it is tragic that we do not have more clarity on this crucial issue."

Dr. Chabner's editorial, Dr. Bach's letter and Dr. Henschke's reply, published by "The Oncologist," are freely available:

Dr. Chabner editorial:

Dr. Bach Letter to Editor:

Dr. Henschke Response:

About AlphaMed Press

AlphaMed Press publishes the internationally renowned journals, "Stem Cells" and "The Oncologist." "Stem Cells," now in its 26th year, is the oldest and one of the world's top-tier peer-reviewed monthly journals in the fast-paced area of stem cells and regenerative medicine. "The Oncologist," in its 13th year, is a premier peer-reviewed monthly journal dedicated to physicians entrusted with the care of cancer patients. View AlphaMed Press journals at

Contact: Dr. Martin J. Murphy, Executive Editor: 919.402.8750,

SOURCE AlphaMed Press
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. - New Site for Parents Seeking Answers to Children's Health Questions
2. On the Third Anniversary of Hurricane Katrina; Trust for Americas Health Questions State of National Emergency Preparedness
3. NJHA Raises Questions Regarding Horizons Proposal to Convert to For-Profit Health Insurer
4. Summer Games Swap Raises Questions About Image, Oral Health
5. Ten Questions to Ask When Considering COBRA Following a Disability
6. Why Do Drugs Cost So Much? and why are we so darn sick?: New Book Reveals Inner Workings of Big Pharma, Asks Hard Questions About Our Health
7. Major Union Questions PA Pension Fund, Calls on PSERS to Protect Workers, Retirees
8. New URAC Issue Brief Answers Questions About Delegated Credentialing, Transparency in Physician Tiering Programs
9. Edwards Lifesciences Receives Additional Questions From the FDA About the LifeStent Product Line
10. Study raises questions about prostate cancer therapies targeting IGF-1
11. Moral philosopher questions memory manipulation
Post Your Comments:
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
Breaking Medicine Technology: